GRM2
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Official Full Name
glutamate receptor, metabotropic 2
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Overview
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and;metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function;and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G;protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal;transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been;shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.;Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist;selectivities. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GRM2; glutamate receptor, metabotropic 2; metabotropic glutamate receptor 2; GPRC1B; mGlu2; MGLUR2; glutamate receptor homolog; glutamate metabotropic receptor 2; GLUR2;
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GRM2 involved in several pathways and played different roles in them. We selected most pathways GRM2 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipase D signaling pathway | PIK3R1;DGKD;GRM7;CYTH3;LPAR5;DGKZ;INS;SYK;PTK2B |
| Neuroactive ligand-receptor interaction | GABRA1;PARD3;P2RY2;GRIA1B;APLNRB;AGTR1B;GHRA;GRM5;OXTR |
| Glutamatergic synapse | PLA2G4D;MAPK1;SLC38A3;GRIA2;GRIA4;GNAQ;GNG7;GNG2;PRKCG |
| Cocaine addiction | GRIN2A;CREB3;NFKB1;RGS9;GRIN1;DRD1;GNAI1;MAOA;GRM3 |
GRM2 has several biochemical functions, for example, G-protein coupled receptor activity, calcium channel regulator activity, glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM2 itself. We selected most functions GRM2 had, and list some proteins which have the same functions with GRM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | GHRHR;TAAR8A;GPR110;LPAR4;TAAR12E;GPR81;TAS2R103;GPR68;FZD5 |
| calcium channel regulator activity | Crisp4;TSPAN13B;CACNA2D1A;NRXN1;GNB2;SGK2;NPY;CACNA2D4;NRXN2 |
| glutamate receptor activity | GRM1;GRIK3;GRM6;GRM3;GRID2;GRM5;GRM8;GRIA1;GRM7 |
| group II metabotropic glutamate receptor activity | GRM3;GRM2;GRM2A |
| protein binding | PPIL3;MTRR;UBLCP1;CD200R4;CDT1;SMN2;CDC40;RARG;PMF1 |
GRM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM2.
NAALADL2; UBQLN1
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