grm2

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grm2

Official Full Name glutamate receptor, metabotropic 2
Background L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and;metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function;and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G;protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal;transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been;shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.;Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist;selectivities. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms GRM2; glutamate receptor, metabotropic 2; metabotropic glutamate receptor 2; GPRC1B; mGlu2; MGLUR2; glutamate receptor homolog; glutamate metabotropic receptor 2; GLUR2
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRM2-5364H Recombinant Human GRM2 Protein Wheat Germ N/A
    Human GRM2-5365H Recombinant Human GRM2 Protein, GST-tagged Wheat Germ GST
    Human GRM2-5736HCL Recombinant Human GRM2 293 Cell Lysate HEK293 N/A
    Mouse GRM2-7285M Recombinant Mouse GRM2 Protein Mammalian Cell His
    Rat GRM2-2714R Recombinant Rat GRM2 Protein Mammalian Cell His
    Rhesus Macaque GRM2-1977R Recombinant Rhesus monkey GRM2 Protein, His-tagged Mammalian Cell His
    Kit-1096 Overall Exosome Capture and Quantification Assay Kit (Human Urine, Luminometric) N/A
    Kit-1334 cAMP GRM2 CHO-K1 GPCR Assay Kit N/A

    grm2 involved in several pathways and played different roles in them. We selected most pathways grm2 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with grm2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway AKT1; AGTR1B; SOS1; GRM8; IL-8; INS2; RHOA; PIP5K1C; GAB2; PLA2G4A
    Neuroactive ligand-receptor interaction TRHRB; F2R; TAAR12E; TAAR10C; CHRNB3B; DRD1B; TAAR14F; C5AR1; TAAR12A; TRPV1
    Glutamatergic synapse PLA2G4C; PPP3R1; GRIK1; HOMER3; GRIK3; GRIK5; ITPR3; GNG5; GNG7; GNB2
    Cocaine addiction GRIN2B; GNAI2; GNAI3; MAOB; GRIN1; RELA; PRKACB; PRKACA; GPSM1; RGS9

    grm2 has several biochemical functions, for example, G-protein coupled receptor activity, calcium channel regulator activity, glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by grm2 itself. We selected most functions grm2 had, and list some proteins which have the same functions with grm2. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor activity TPRA1; OLFCG2; OPN4XA; NPFFR2.1; OLFR11; LPHN1; GPR61; GPR63; GPR176; GPR97
    calcium channel regulator activity SGK2; PRKG1; NPY2R; NRXN1; CRISP1; CACNA2D2; TSPAN13A; GRM3; TSPAN13; PRKCB
    glutamate receptor activity GRM7; GRID2; GRM8; GRM6; GRM2; GRIA1; GRM3; GRM1; GRM4; GRM5
    group II metabotropic glutamate receptor activity GRM2; GRM3; GRM2A
    protein binding PNOC; CAP2; ERBB2; MYBPH; EIF4EBP3L; SEC61B; PSMB2; FYB; BAG4; GNAT1

    grm2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with grm2 here. Most of them are supplied by our site. Hope this information will be useful for your research of grm2.

    NAALADL2; UBQLN1

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