| Description : |
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq |
| Source : |
Wheat Germ |
| Species : |
Human |
| Form : |
Liquid |
| Molecular Mass : |
95.6 kDa |
| AA Sequence : |
MGSLLALLALLLLWGAVAEGPAKKV LTLEGDLVLGGLFPVHQKGGPAEDC GPVNEHRGIQRLEAMLFALDRINRD PHLLPGVRLGAHILDSCSKDTHALE QALDFVRASLSRGADGSRHICPDGS YATHGDAPTAITGVIGGSYSDVSIQ VANLLRLFQIPQISYASTSAKLSDK SRYDYFARTVPPDFFQAKAMAEILR FFNWTYVSTVASEGDYGETGIEAFE LEARARNICVATSEKVGRAMSRAAF EGVVRALLQKPSARVAVLFTRSEDA RELLAASQRLNASFTWVASDGWGAL ESVVAGSEGAAEGAITIELASYPIS DFASYFQSLDPWNNSRNPWFREFWE QRFRCSFRQRDCAAHSLRAVPFEQE SKIMFVVNAVYAMAHALHNMHRALC PNTTRLCDAMRPVNGRRLYKDFVLN VKFDAPFRPADTHNEVRFDRFGDGI GRYNIFTYLRAGSGRYRYQKVGYWA EGLTLDTSLIPWASPSAGPLPASRC SEPCLQNEVKSVQPGEVCCWLCIPC QPYEYRLDEFTCADCGLGYWPNASL TGCFELPQEYIRWGDAWAVGPVTIA CLGALATLFVLGVFVRHNATPVVKA SGRELCYILLGGVFLCYCMTFIFIA KPSTAVCTLRRLGLGTAFSVCYSAL LTKTNRIARIFGGAREGAQRPRFIS PASQVAICLALISGQLLIVVAWLVV EAPGTGKETAPERREVVTLRCNHRD ASMLGSLAYNVLLIALCTLYAFKTR KCPENFNEAKFIGFTMYTTCIIWLA FLPIFYVTSSDYRVQTTTMCVSVSL SGSVVLGCLFAPKLHIILFQPQKNV VSHRAPTSRFGSAAARASSSLGQGS GSQFVPTVCNGREVVDSTTSSL |
| Applications : |
Antibody Production
Functional Study
Compound Screening |
| Usage : |
Heating may cause protein aggregation. Please do not heat this product before electrophoresis. |
| Notes : |
Best use within three months from the date of receipt of this protein. |
| Storage : |
Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
| Storage Buffer : |
25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
