HCN4
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Official Full Name
hyperpolarization activated cyclic nucleotide-gated potassium channel 4 -
Overview
The human HCN4 gene encodes the pore-forming subunit of a hyperpolarization-activated cation channel. HCN4 channels contribute to pacemaker currents in the heart and brain. -
Synonyms
HCN4;hyperpolarization activated cyclic nucleotide-gated potassium channel 4;potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4;hyperpolarization activated cyclic nucleotide-gated cation channel 4;SSS2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HCN4-3477H | Recombinant Human HCN4 protein, His-tagged | E.coli | Human | His | 1-213 aa | |
| HCN4-2809R | Recombinant Rat HCN4 Protein | Mammalian Cell | Rat | His |
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| HCN4-4630H | Recombinant Human HCN4 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HCN4-1183HFL | Recombinant Human HCN4 protein, His&Flag-tagged | HEK293 | Human | His&Flag | 1-1203 aa |
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| HCN4-2464R | Recombinant Rat HCN4 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| HCN4-2464R-B | Recombinant Rat HCN4 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
HCN4 involved in several pathways and played different roles in them. We selected most pathways HCN4 participated on our site, such as HCN channels,Neuronal System,Potassium Channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with HCN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Potassium Channels | KCNK1,KCNV1,KCNC1A,KCNJ1A.4,KCNAB1,KCNS2,KCNQ2A,KCNJ1A.5,KCNAB2,KCNB2 |
| Neuronal System | KCNB2,KCND2,DDX1,KCNJ1A.4,KCNK3A,KCNN3,KCND3,PANX1B,KCNJ1A.3,KCNH1A |
| cAMP signaling pathway | GNAI1,HHIP,GRIN2B,MAPK9,NPY,NPR1,CALML3,PPP1CA,CAMK2A,HTR1B |
Protein Function
HCN4 has several biochemical functions, for example, cAMP binding,identical protein binding,intracellular cAMP activated cation channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HCN4 itself. We selected most functions HCN4 had, and list some proteins which have the same functions with HCN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated sodium channel activity | PKD2,SCN9A,ASIC4A,SCN12AA,SCN8AB,SCN4AA,SCN3A,SCN8AA,SCN12AB,SCN11A |
| intracellular cAMP activated cation channel activity | HCN2,CNGA5,CNGA3,CNGA1,CNGA4 |
| voltage-gated potassium channel activity | KCNC1B,KCNAB2,KCNQ2A,KCNAB1,KCNT1,KCNH6A,KCNH8,KCNC1,KCNQ1,KCNAB2B |
| identical protein binding | EWSR1,SHANK1,ST13,CLDN14,ITGB3,TARDBP,APLP1,S100A1,USP15,HOOK3 |
| cAMP binding | PRKAR1B,RAPGEF4,HCN2,PRKAR2A,CNMPD1,POPDC2,PRKAR1A,PDE10A,PDE2A,PDE4B |
Interacting Protein
HCN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HCN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HCN4.
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References
- Pauza, DH; Rysevaite, K; et al. Innervation of sinoatrial nodal cardiomyocytes in mouse. A combined approach using immunofluorescent and electron microscopy. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 75:188-197(2014).
- Newton, CM; Stoyek, MR; et al. Regional Innervation of the Heart in the Goldfish, Carassius auratus: A Confocal Microscopy Study. JOURNAL OF COMPARATIVE NEUROLOGY 522:456-478(2014).
