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IGF2BP3

  • Official Full Name

    insulin-like growth factor 2 mRNA binding protein 3

  • Overview

    Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor. The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded prot
  • Synonyms

    IGF2BP3; insulin-like growth factor 2 mRNA binding protein 3; insulin-like growth factor 2 mRNA-binding protein 3; cancer/testis antigen 98; CT98; IGF II mRNA binding protein 3; IMP 3; hKOC; VICKZ family member 3; IGF2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; KH domain-containing protein overexpressed in cancer; IMP3; KOC1; IMP-3; VICKZ3; DKFZp686F1078; OTTHUMP00000158561; VICKZ3.;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IGF2BP3-14103H Recombinant Human IGF2BP3 protein, GST-tagged E.coli GST 240-579 aa
Human IGF2BP3-16H Recombinant Human IGF2BP3 protein, His/T7-tagged E.coli His/T7
Human IGF2BP3-17H Recombinant Human IGF2BP3 protein, His-tagged E.coli His
Human IGF2BP3-5147H Recombinant Human IGF2BP3 Protein, GST-tagged Wheat Germ GST
Human IGF2BP3-3437H Recombinant Human IGF2BP3 Protein (Asn2-Ile343), N-His tagged E.coli N-His Asn2-Ile343
Human IGF2BP3-3360H Recombinant Human IGF2BP3 protein, His-tagged E.coli His 240-579 aa
Human IGF2BP3-5855HF Recombinant Full Length Human IGF2BP3 Protein, GST-tagged In Vitro Cell Free System GST 579 amino acids
Mouse IGF2BP3-8068M Recombinant Mouse IGF2BP3 Protein Mammalian Cell His
Mouse IGF2BP3-4464M Recombinant Mouse IGF2BP3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse IGF2BP3-4464M-B Recombinant Mouse IGF2BP3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IGF2BP3-9044Z Recombinant Zebrafish IGF2BP3 Mammalian Cell His
Chicken IGF2BP3-1503C Recombinant Chicken IGF2BP3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

IGF2BP3 involved in several pathways and played different roles in them. We selected most pathways IGF2BP3 participated on our site, such as Gene Expression, Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2BP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionZBTB8OS;RRAGB;ZNF498;DDOST;AEBP2;ZNF621;MED31;METTL1;HNRNPD
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNAIGF2BP2;IGF2BP3;IGF2BP1

IGF2BP3 has several biochemical functions, for example, RNA binding, mRNA 3-UTR binding, mRNA 5-UTR binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2BP3 itself. We selected most functions IGF2BP3 had, and list some proteins which have the same functions with IGF2BP3. You can find most of the proteins on our site.

Function Related Protein
RNA bindingPABPN1L;PSMA1;RBM27;RBM39B;EXOSC9;ASCC1;RNMTL1B;APOBEC2;SCAF8
mRNA 3-UTR bindingCPEB1A;IGF2BP3;CPEB3;RBM38;TES;PARN;KHSRP;TUT1;SECISBP2
mRNA 5-UTR bindingIGF2BP2;RPS14;IGF2BP1;IGF2BP3;DDX3X;LARP1;MRPS11
nucleotide bindingMYO6A;NCBP2;TDRD9;RHOUB;STK35L;CLCN6;BAT1;MYHZ1.1;RABL6
poly(A) RNA bindingRPS25;HARS2;HIST1H4K;CTNNA1;RPS28;SF3B14;HSPD1;PARP12;TRMT1
protein bindingSEMA4D;RNF138;UBE3A;CCDC151;LRIF1;PPAP2B;RACGAP1;MYOZ1;C14orf93
translation regulator activityIGF2BP1;IGF2BP3;YBX2;AIRE;RPS14;IGF2BP2;RPS9

IGF2BP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2BP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2BP3.

CNBP; Ybx1; POLR1E; PUF60; midostaurin; ssrna_ug

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