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Official Full Name insulin-like growth factor 2 mRNA binding protein 3
Background Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor. The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded prot
Synonyms IGF2BP3; insulin-like growth factor 2 mRNA binding protein 3; insulin-like growth factor 2 mRNA-binding protein 3; cancer/testis antigen 98; CT98; IGF II mRNA binding protein 3; IMP 3; hKOC; VICKZ family member 3; IGF2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; KH domain-containing protein overexpressed in cancer; IMP3; KOC1; IMP-3; VICKZ3; DKFZp686F1078; OTTHUMP00000158561; VICKZ3.
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IGF2BP3-14103H Recombinant Human IGF2BP3, GST-tagged E.coli GST
    Human IGF2BP3-16H Recombinant Human IGF2BP3 protein, His/T7-tagged E.coli His/T7
    Human IGF2BP3-17H Recombinant Human IGF2BP3 protein, His-tagged E.coli His
    Human IGF2BP3-5147H Recombinant Human IGF2BP3 Protein, GST-tagged Wheat Germ GST
    Mouse IGF2BP3-8068M Recombinant Mouse IGF2BP3 Protein Mammalian Cell His
    Chicken IGF2BP3-1503C Recombinant Chicken IGF2BP3 Mammalian Cell His
    Zebrafish IGF2BP3-9044Z Recombinant Zebrafish IGF2BP3 Mammalian Cell His

    igf2bp3 involved in several pathways and played different roles in them. We selected most pathways igf2bp3 participated on our site, such as Gene Expression, Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with igf2bp3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression AIMP1; ZNF567; MED7; QTRT1; ZFP28; ZNF599; COX16; ZNF398; PUS7; APOBEC1
    Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA IGF2BP2; IGF2BP1; IGF2BP3

    igf2bp3 has several biochemical functions, for example, RNA binding, mRNA 3-UTR binding, mRNA 5-UTR binding. Some of the functions are cooperated with other proteins, some of the functions could acted by igf2bp3 itself. We selected most functions igf2bp3 had, and list some proteins which have the same functions with igf2bp3. You can find most of the proteins on our site.

    Function Related Protein
    mRNA 5-UTR binding IGF2BP2; LARP1; DDX3X; RPS14; IGF2BP3; IGF2BP1; MRPS11
    nucleotide binding ABCC8; RNPS1; RBM3; RPL23A; SNRKB; UBE2G1B; CSF1RA; CIRBP; EPHA4B; DGKAA
    poly(A) RNA binding SSB; SRSF1; METAP2; GSPT2; LRRC59; NOL12; CIRH1A; PSPC1; FCF1; EMG1
    protein binding Icosl; PELP1; POLH; GGT1; TXNDC11; S100A13; MAP2K3; NDUFB10; MCC; RCOR3
    translation regulator activity IGF2BP1; RPS9; IGF2BP3; IGF2BP2; YBX2; AIRE; RPS14

    igf2bp3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with igf2bp3 here. Most of them are supplied by our site. Hope this information will be useful for your research of igf2bp3.

    CNBP; Ybx1; POLR1E; PUF60; midostaurin; ssrna_ug

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