IL1RAPL1
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Official Full Name
interleukin 1 receptor accessory protein-like 1
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Overview
The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. -
Synonyms
IL1RAPL1; interleukin 1 receptor accessory protein-like 1; IL1RAPL, mental retardation, X linked 10 , mental retardation, X linked 21 , mental retardation, X linked 34 , MRX10, MRX21, MRX34; interleukin-1 receptor accessory protein-like 1; IL1R8; OPHN4; TIGIRR 2; IL 1 RAPL 1; IL 1RAPL 1; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL 1; IL1RAPL; IL1RAPL-1; Interleukin 1 receptor 8; Interleukin 1 receptor accessory protein like 1; IRPL1_HUMAN; Mental retardation X linked 10; Mental retardation X linked 21; Mental retardation X linked 34; MRX 21; MRX 34; MRX10; MRX21; MRX34; Oligophrenin 4; Oligophrenin-4; Oligophrenin4; OPHN 4; Three immunoglobulin domain containing IL 1 receptor related 2; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; TIGIRR2; X linked interleukin 1 receptor accessory protein like 1; X-linked interleukin-1 receptor accessory protein-like 1; interleukin 1 receptor-8; mental retardation, X-linked 10; three immunoglobulin domain-containing IL-1 r;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Mus musculus (Mouse)
- Pan troglodytes (Chimpanzee)
- Rat
- Rattus norvegicus (Rat)
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- Mammalian Cell
- Fc
- His
- Avi
- T7
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
IL1RAPL1 involved in several pathways and played different roles in them. We selected most pathways IL1RAPL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1RAPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
IL1RAPL1 has several biochemical functions, for example, NOT interleukin-1 binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1RAPL1 itself. We selected most functions IL1RAPL1 had, and list some proteins which have the same functions with IL1RAPL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT interleukin-1 binding | |
| protein binding | UTP3;RPN1;PINX1;HIST1H2AM;OLFM1;VPS18;ZNF792;CADPS;PKN3 |
| receptor binding | PANX1;RIPK2;CSNK2B;NTF3;PVRL1;ECI2;HTT;HAMP;EDA |
| voltage-gated calcium channel activity | TPCN2;CACNG2B;CACNB2A;GRM7;ATP6V0CB;CACNG2A;GAS6;CACNB3A;CACNG7 |
IL1RAPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1RAPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1RAPL1.
CFTR
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewEffective in inflammation studies.
High specificity.
Suitable for cytokine assays.
Q&As (10)
Ask a questionLinked to intellectual disabilities.
Higher in the hippocampus and cortex.
Increases during early development, decreases in adulthood.
Forms heterodimers with IL-1RI.
Binds directly to the PDZ domains of PSD-95.
Involved in excitatory synapse formation.
Upregulated in neuroinflammatory conditions.
Yes, multiple isoforms exist.
Subject to ubiquitination.
Affects spine density and shape.
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