• Official Full Name

    interleukin 1 receptor accessory protein-like 1

  • Background

    The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities.
  • Synonyms

    IL1RAPL1; interleukin 1 receptor accessory protein-like 1; IL1RAPL, mental retardation, X linked 10 , mental retardation, X linked 21 , mental retardation, X linked 34 , MRX10, MRX21, MRX34; interleukin-1 receptor accessory protein-like 1; IL1R8; OPHN4; TIGIRR 2; IL 1 RAPL 1; IL 1RAPL 1; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL 1; IL1RAPL; IL1RAPL-1; Interleukin 1 receptor 8; Interleukin 1 receptor accessory protein like 1; IRPL1_HUMAN; Mental retardation X linked 10; Mental retardation X linked 21; Mental retardation X linked 34; MRX 21; MRX 34; MRX10; MRX21; MRX34; Oligophrenin 4; Oligophrenin-4; Oligophrenin4; OPHN 4; Three immunoglobulin domain containing IL 1 receptor related 2; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; TIGIRR2; X linked interleukin 1 receptor accessory protein like 1; X-linked interleukin-1 receptor accessory protein-like 1; interleukin 1 receptor-8; mental retardation, X-linked 10; three immunoglobulin domain-containing IL-1 r;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Tag :
    • Fc
    • His
    • His (Fc)
    • Avi
    • His|T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL1RAPL1-975H Recombinant Human IL1RAPL1 protein, His-tagged E. coli His
    Human IL1RAPL1-2740HCL Recombinant Human IL1RAPL1 cell lysate Human Cell N/A
    Human IL1RAPL1-1575H Recombinant Human IL1RAPL1 protein, His & T7-tagged E.coli His/T7
    Human IL1RAPL1-2784HCL Recombinant Human IL1RAPL1 cell lysate Human Cell N/A
    Human IL1RAPL1-776H Recombinant Human IL1RAPL1, Fc tagged Human Cell Fc
    Human IL1RAPL1-777H Recombinant Human IL1RAPL1, His tagged Human Cell His
    Mouse IL1RAPL1-1688MCL Recombinant Mouse IL1RAPL1 cell lysate Human Cell N/A
    Mouse Il1rapl1-6962M Recombinant Mouse Il1rapl1, Fc tagged Human Cell Fc
    Rat IL1RAPL1-3034R Recombinant Rat IL1RAPL1 Protein Mammalian Cell His
    Rat IL1RAPL1-2689R Recombinant Rat IL1RAPL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat IL1RAPL1-2689R-B Recombinant Rat IL1RAPL1 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL1RAPL1 Related Gene Family
    • IL1RAPL1 Related Research Area

    IL1RAPL1 involved in several pathways and played different roles in them. We selected most pathways IL1RAPL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1RAPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    IL1RAPL1 has several biochemical functions, for example, NOT interleukin-1 binding, protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1RAPL1 itself. We selected most functions IL1RAPL1 had, and list some proteins which have the same functions with IL1RAPL1. You can find most of the proteins on our site.

    Function Related Protein
    NOT interleukin-1 binding
    protein bindingLRRC20;KMT2E;TAPBP;PIK3CG;ALDH18A1;SOAT1;SNX31;ADORA2A;GIT1
    receptor bindingANGPT2;PLXNC1;CNTFR;ABL2;ECH1;MAP7;PARK7;CD86;CADM1A
    voltage-gated calcium channel activityCACNB2B;CACNG2;CACNA1SB;CATSPER3;CACNA1C;CACNG1A;CACNA1BA;CACNG7;OPRM1

    IL1RAPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1RAPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1RAPL1.


    • Q&As
    • Reviews

    Q&As (10)

    Ask a question
    Can IL1RAPL1 mutations be linked to specific neurological disorders? 06/27/2022

    Linked to intellectual disabilities.

    How does IL1RAPL1 expression vary in different brain regions? 01/27/2022

    Higher in the hippocampus and cortex.

    How does IL1RAPL1 expression change during neural development? 10/01/2021

    Increases during early development, decreases in adulthood.

    How does IL1RAPL1 interact with other members of the IL-1 receptor family? 07/27/2021

    Forms heterodimers with IL-1RI.

    How does IL1RAPL1 interact with PSD-95 in neurons? 12/22/2020

    Binds directly to the PDZ domains of PSD-95.

    What is the role of IL1RAPL1 in synaptic plasticity? 09/28/2020

    Involved in excitatory synapse formation.

    Is IL1RAPL1 expression affected by neuroinflammatory conditions? 02/26/2020

    Upregulated in neuroinflammatory conditions.

    Does IL1RAPL1 have any alternative splicing variants? 04/09/2019

    Yes, multiple isoforms exist.

    What post-translational modifications occur on IL1RAPL1? 08/01/2018

    Subject to ubiquitination.

    Does IL1RAPL1 have a role in dendritic spine morphology? 06/12/2018

    Affects spine density and shape.

    Customer Reviews (3)

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      Effective in inflammation studies. -


        High specificity. -


          Suitable for cytokine assays. -

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