Active Recombinant Mouse Il1rapl1 protein(Met1-Thr357), hFc-tagged

Cat.No. : Il1rapl1-6962M
Product Overview : Recombinant Mouse IL1RAPL1 (P59823) extracellular domain (Met 1-Thr 357) was expressed in HEK293, fused with the Fc region of Human IgG1 at the C-terminus.
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  • Gene Information
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Source : HEK293
Species : Mouse
Tag : C-hFc
Protein length : Met1-Thr357
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : Measured by its ability to bind biotinylated human IL1α in functional ELISA.
Molecular Mass : The secreted recombinant mouse IL1RAPL1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 574 amino acids and has a calculated molecular mass of 65 kDa. As a result of glycosylation, the apparent molecular mass of rmIL1RAPL1/Fc monomer is approximately 85-95 kDa in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 95 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : Il1rapl1 interleukin 1 receptor accessory protein-like 1 [ Mus musculus ]
Official Symbol : Il1rapl1
Synonyms : IL1RAPL1; interleukin 1 receptor accessory protein-like 1; interleukin-1 receptor accessory protein-like 1; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1; X-linked interleukin-1 receptor accessory protein-like 1; IL1R8; MRX34; OPHN4; IL1RAPL; TIGIRR-2; C030039N24; 6330532G10Rik;
Gene ID : 331461
mRNA Refseq : NM_001160403
Protein Refseq : NP_001153875

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Can IL1RAPL1 mutations be linked to specific neurological disorders? 06/27/2022

Linked to intellectual disabilities.

How does IL1RAPL1 expression vary in different brain regions? 01/27/2022

Higher in the hippocampus and cortex.

How does IL1RAPL1 expression change during neural development? 10/01/2021

Increases during early development, decreases in adulthood.

How does IL1RAPL1 interact with other members of the IL-1 receptor family? 07/27/2021

Forms heterodimers with IL-1RI.

How does IL1RAPL1 interact with PSD-95 in neurons? 12/22/2020

Binds directly to the PDZ domains of PSD-95.

What is the role of IL1RAPL1 in synaptic plasticity? 09/28/2020

Involved in excitatory synapse formation.

Is IL1RAPL1 expression affected by neuroinflammatory conditions? 02/26/2020

Upregulated in neuroinflammatory conditions.

Does IL1RAPL1 have any alternative splicing variants? 04/09/2019

Yes, multiple isoforms exist.

What post-translational modifications occur on IL1RAPL1? 08/01/2018

Subject to ubiquitination.

Does IL1RAPL1 have a role in dendritic spine morphology? 06/12/2018

Affects spine density and shape.

Customer Reviews (3)

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Reviews
07/08/2022

    Effective in inflammation studies.

    03/20/2020

      High specificity.

      07/30/2017

        Suitable for cytokine assays.

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