Recombinant Human IL1RAPL1 protein, His & T7-tagged

• Cat.No.: IL1RAPL1-1575H
• Product Overview: Recombinant Human IL1RAPL1 aa. (Ser113~Asp276 (Accession # Q9NZN1)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Description: The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. This protein has an N-terminal signal peptide, three extracellular immunoglobulin Ig-like domains, a transmembrane domain, an intracellular Toll/IL-1R domain, and a long C-terminal tail which interacts with multiple signalling molecules. This gene is located at a region on chromosome X that is associated with a non-syndromic form of X-linked intellectual disability. Deletions and mutations in this gene were found in patients with intellectual disability. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities, and plays a role in synapse formation and stabilization.
• Source: E. coli
• Species: Human
• Tag: His & T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 22.5kDa
• Protein length: Ser113~Asp276 (Accession # Q9NZN1)
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 7.5

Gene Information

• Gene Name: IL1RAPL1 interleukin 1 receptor accessory protein like 1 [ Homo sapiens (human) ]
• Official Symbol: IL1RAPL1
• Synonyms: IL1RAPL1; interleukin 1 receptor accessory protein like 1; IL1R8; MRX10; MRX21; MRX34; OPHN4; IL1RAPL; TIGIRR-2; IL1RAPL-1; IL-1RAPL-1; interleukin-1 receptor accessory protein-like 1; IL-1-RAPL-1; X-linked interleukin-1 receptor accessory protein-like 1; interleukin 1 receptor-8; mental retardation, X-linked 10; oligophrenin-4; three immunoglobulin domain-containing IL-1 receptor-related 2
• Gene ID: 11141
• mRNA Refseq: NM_014271.3
• Protein Refseq: NP_055086.1
• UniProt ID: Q9NZN1