ISCU

  • Official Full Name

    iron-sulfur cluster scaffold homolog (E. coli)

  • Overview

    Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins.;They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors,;chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster;scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance;and myoglobinuria.

  • Synonyms

    ISCU;iron-sulfur cluster scaffold homolog (E. coli);iron-sulfur cluster assembly enzyme ISCU, mitochondrial;mitochondrial;2310020H20Rik;HML;hnifU;Iron sulfur cluster assembly enzyme ISCU mitochondrial;Iron sulfur cluster scaffold homolog (E. coli);Iron sulfur cluster scaffold homolog;Iron-sulfur cluster assembly enzyme ISCU;IscU iron sulfur cluster scaffold homolog;ISCU_HUMAN;ISU2;MGC74517;NIFU;NifU like N terminal domain containing;NifU like N terminal domain containing protein;NifU like protein;NifU-like N-terminal domain-containing protein;NifU-like protein;NIFUN;Nitrogen fixation cluster like;OTTHUMP00000238760;OTTHUMP00000238761;OTTHUMP00000238762;OTTHUMP00000238764;OTTHUMP00000238765;IscU iron-sulfur cluster scaffold homolog;RGD1309562

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Mouse
  • Bacillus subtilis
  • Mammalian Cells
  • E.coli
  • HEK293
  • Insect Cells
  • E.Coli/Yeast
  • Yeast
  • His
  • Non
  • Avi
  • Fc
  • Myc
  • DDK
  • GST
  • SUMO

    Involved Pathway

    ISCU involved in several pathways and played different roles in them. We selected most pathways ISCU participated on our site, such as Metabolism,Mitochondrial iron-sulfur cluster biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ISCU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mitochondrial iron-sulfur cluster biogenesis ISCUB,LYRM4
    Metabolism PTPMT1,SLC27A2,BHMT2,AGL,LMF2,AK7,CHST9,DBH,CPNE6,NUDT5

    Protein Function

    ISCU has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding,4 iron, 4 sulfur cluster binding,ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ISCU itself. We selected most functions ISCU had, and list some proteins which have the same functions with ISCU. You can find most of the proteins on our site.

    Function Related Protein
    protein binding TIMP1,TFG,RBMY1F,CRLF1,DNAJB1,PIP5K1A,RAB8A,PARD3,TDP2,FAM19A4
    2 iron, 2 sulfur cluster binding AOX3,FDX1B,AOX4,NDUFS1,CMAH,ISCA1,CISD1,GLRX5,ISCUB,SDHB
    4 iron, 4 sulfur cluster binding NUBP1,ACO1,DEM1,DPYD,ISCA1,BRIP1,POLA1,NDUFS2,CDKAL1,DPYDB
    ferrous iron binding FTO,CDO1,Trf,HAAO,FXN,SNCA,TF,ALKBH1,BCO1,HEPH
    iron ion binding CYP2K16,CYP2B19,FA2H,CYP19A1B,HBA-X,CALR,CYP2P8,ALOX5A,PLOD1A,CYP2K22
    iron-sulfur transferase activity ISCUB
    protein complex scaffold WWC3,CHCHD3,WWC2,CNOT1,AKAP9,MAP2K2,MAGI1,SEPT2,AKAP6,MPP7

    Interacting Protein

    ISCU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISCU here. Most of them are supplied by our site. Hope this information will be useful for your research of ISCU.

    NECAB2;HPRT1;CCDC172;NUP62;GOLGA2;IKZF1;KRT40

    Resources

    References

    • Tovar, J; Leon-Avila, G; et al. Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation. NATURE 426:172-176(2003).
    • Garland, SA; Hoff, K; et al. Saccharomyces cerevisiae ISU1 and ISU2: Members of a well-conserved gene family for iron-sulfur cluster assembly. JOURNAL OF MOLECULAR BIOLOGY 294:897-907(1999).
    • SOSINSKI, J; THAKAR, JH; et al. CROSS-RESISTANCE TO ANTITUMOR DIARYLSULFONYLUREAS AND COLLATERAL SENSITIVITY TO MITOCHONDRIAL TOXINS IN A HUMAN CELL-LINE SELECTED FOR RESISTANCE TO THE ANTITUMOR AGENT N-(5-INDANYLSULFONYL)N'-(4-CHLOROPHENYL)UREA. MOLECULAR PHARMACOLOGY 45:962-970(1994).

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