Recombinant Mouse Iscu Protein, Myc/DDK-tagged
Cat.No. : | Iscu-3583M |
Product Overview : | Purified recombinant protein of mouse full-length iron-sulfur cluster assembly enzyme (Iscu), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 18.1 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Iscu iron-sulfur cluster assembly enzyme [ Mus musculus (house mouse) ] |
Official Symbol : | Iscu |
Synonyms : | ISCU; IscU iron-sulfur cluster scaffold homolog (E. coli); iron-sulfur cluster assembly enzyme ISCU, mitochondrial; ISCU2; nifU-like protein; NifU-like N-terminal domain containing; nifU-like N-terminal domain-containing protein; Nifu; Nifun; AA407971; 2310020H20Rik |
Gene ID : | 66383 |
mRNA Refseq : | NM_025526 |
Protein Refseq : | NP_079802 |
UniProt ID : | Q9D7P6 |
Products Types
◆ Recombinant Protein | ||
ISCU-4620M | Recombinant Mouse ISCU Protein, His (Fc)-Avi-tagged | +Inquiry |
ISCU-2126R | Recombinant Rhesus Macaque ISCU Protein, His (Fc)-Avi-tagged | +Inquiry |
ISCU-5823H | Recombinant Human ISCU protein, His-sumostar-tagged | +Inquiry |
ISCU-2305R | Recombinant Rhesus monkey ISCU Protein, His-tagged | +Inquiry |
ISCU-2344H | Recombinant Human ISCU protein, His&Myc-tagged | +Inquiry |
◆ Lysates | ||
ISCU-5153HCL | Recombinant Human ISCU 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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