Cytokeratin 19 is a type I acidic subfamily of intermediate filament protein that is expressed in stratified and simple type epithelia. Keratin 19 is not expressed in hepatocytes; therefore, antibody to keratin 19 is useful in the identification of liver metastasis. The degree of keratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Keratin 19 is often co-expressed with keratin 7.
Synonyms
KRT19; keratin 19; K19; CK19; K1CS; keratin, type I cytoskeletal 19; CK-19; keratin-19; cytokeratin 19; cytokeratin-19; keratin, type I, 40-kd; 40-kDa keratin intermediate filament;
KRT19 involved in several pathways and played different roles in them. We selected most pathways KRT19 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT19 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
KRT19 has several biochemical functions, for example, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT19 itself. We selected most functions KRT19 had, and list some proteins which have the same functions with KRT19. You can find most of the proteins on our site.
KRT19 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT19 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT19.
Ju, JH; Oh, S; et al. Cytokeratin19 induced by HER2/ERK binds and stabilizes HER2 on cell membranes. CELL DEATH AND DIFFERENTIATION 22:665-676(2015).
Guzvic, M; Braun, B; et al. Combined Genome and Transcriptome Analysis of Single Disseminated Cancer Cells from Bone Marrow of Prostate Cancer Patients Reveals Unexpected Transcriptomes. CANCER RESEARCH 74:7383-7394(2014).
