Native Human CK19

• Cat.No.: KRT19-5H

Specification

• Description: CTK-19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.
• Source: Human epithelial ovarian cancer cell culture supernatant
• Species: Human
• Form: Liquid
• Applications: ELISA;Other applications have not been tested.
• Storage: Ship at 4°C. Upon receipt, aliquot and store at -20°C or -80°C for long term.Avoid repeated freeze and thaw cycles.
• Concentration: 1 mg/ml
• Storage Buffer: Each vial contains Tris-HCl (pH 7.4 ± 0.2) with 0.2% NaN3.
• Tag: Non

Gene Information

• Gene Name: KRT19 keratin 19 [ Homo sapiens ]
• Official Symbol: KRT19
• Synonyms: KRT19; keratin 19; keratin, type I cytoskeletal 19; 40 kDa keratin intermediate filament; CK19; cytokeratin 19; K1CS; K19; keratin; type I cytoskeletal 19; type I; 40 kd; MGC15366; CK-19; keratin-19; cytokeratin-19; keratin, type I, 40-kd; 40-kDa keratin
• Gene ID: 3880
• mRNA Refseq: NM_002276
• Protein Refseq: NP_002267
• MIM: 148020
• UniProt ID: P08727
• Chromosome Location: 17q21-q23
• Pathway: Signaling mediated by p38-alpha and p38-beta, organism-specific biosystem
• Function: protein binding; structural constituent of cytoskeleton; structural constituent of muscle

Reviews

08/25/2021

Such support helps researchers overcome challenges and obtain reliable results.

11/22/2020

This flexibility allows researchers to focus on specific aspects of KRT19 protein functionality, regulation, or disease associations, enhancing the relevance and applicability of their work.

08/26/2020

Manufacturers might offer customization options, such as different variants or modifications of the KRT19 protein, to cater to specific research requirements.

Q&As

Are there any clinical trials involving KRT19 protein?

Yes, there are ongoing clinical trials exploring the use of KRT19 as a biomarker and its potential as a therapeutic target in cancer treatment.

Are there any non-cancer clinical applications of KRT19?

Yes, KRT19 can also be used as a biomarker in other diseases, such as liver diseases and rheumatoid arthritis.

Are there any targeted therapies based on KRT19 expression?

Some targeted therapies are being developed that specifically target cancer cells with high KRT19 expression.

Can KRT19 protein be used to predict the prognosis of cancer patients?

Yes, KRT19 expression levels can provide information about the prognosis of cancer patients, helping in treatment planning.

How is KRT19 protein detected in clinical samples?

KRT19 protein can be detected using various laboratory techniques, including immunohistochemistry, ELISA, and PCR.