NF2

  • Official Full Name

    neurofibromin 2 (merlin)

  • Overview

    This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts.
  • Synonyms

    NF2; neurofibromin 2 (merlin); merlin; neurofibromin 2 (bilateral acoustic neuroma); Moesin-ezrin-radixin-like protein; SCH; CAN; BANF; OTTHUMP00000199607; moesin-ezrin-radixin like; moesin-ezrin-radizin-like protein; neurofibromin-2; schwannomerlin; schwannomin; ACN; OTTHUMP00000028855; OTTHUMP00000199606; OTTHUMP00000199608; OTTHUMP00000199609; OTTHUMP00000199610; OTTHUMP00000199611; OTTHUMP00000199621; OTTHUMP00000199622;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Trx
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NF2-22H Recombinant Human NF2 protein, GST-tagged Wheat Germ GST
Human NF2-747H Recombinant Human NF2 Protein, His-tagged E.coli His
Human NF2-840H Recombinant Human NF2 Mammalian Cell His
Human NF2-3861HCL Recombinant Human NF2 293 Cell Lysate HEK293 N/A
Human NF2-3862HCL Recombinant Human NF2 293 Cell Lysate HEK293 N/A
Human NF2-3273H Recombinant Human NF2 protein, His-tagged E.coli His 1-595aa
Human NF2-3617H-B Recombinant Human NF2 Protein Pre-coupled Magnetic Beads HEK293
Human NF2-3617H Recombinant Human NF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NF2-4687H Recombinant Human NF2 Protein (Asp30-Leu239), N-His tagged E.coli N-His Asp30-Leu239
Mouse NF2-10607M Recombinant Mouse NF2 Protein Mammalian Cell His
Mouse Nf2-2000M Recombinant Mouse Nf2 protein, His & T7-tagged E.coli His/T7 Asp30~Arg311 (Accession # P46662)
Mouse NF2-6029M-B Recombinant Mouse NF2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Nf2-3274M Recombinant Mouse Nf2 protein, His-Trx-tagged E.coli His-Trx 1-320aa
Mouse NF2-6029M Recombinant Mouse NF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NF2-3010R Recombinant Rhesus monkey NF2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NF2-2829R Recombinant Rhesus Macaque NF2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NF2-2829R-B Recombinant Rhesus Macaque NF2 Protein Pre-coupled Magnetic Beads HEK293
Chicken NF2-6067C Recombinant Chicken NF2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NF2 Related Articles
  • NF2 Related Research Area
  • NF2 Related Signal Pathway

NF2 involved in several pathways and played different roles in them. We selected most pathways NF2 participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NF2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hippo signaling pathwayPARD6A;DLG1;WNT8B;SMAD7;WNT5A;DLG3;SERPINE1;WWTR1;AXIN2

NF2 has several biochemical functions, for example, actin binding, beta-catenin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NF2 itself. We selected most functions NF2 had, and list some proteins which have the same functions with NF2. You can find most of the proteins on our site.

Function Related Protein
actin bindingMTSS1L;FSCN2A;CNN3;MYO1C;TBCCD1;EVL;CNN1A;WASF1;CAMK2B
beta-catenin bindingAPC2;HDAC6;SMAD7;BCL9L;CDH24;SHROOM2;TBL1XR1;CDH1;EP300
integrin bindingDMP1;CYR61L1;Tcam1;GPNMB;ESM1;TSPAN8;SYK;NIPAL1;DST
protein bindingGSTK1;TAF11;HNRPDL;MOCS3;TRA2B;RPS2;FRMD7;ATG13;SP3
protein domain specific bindingHOXB1;HNRNPM;NFASC;HIST1H4J;LAMP1;FOXA3;TRP63;RHOA;STX1A

NF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NF2.

AMOT; MAP3K11; GTPBP4

Bhimrao, SK; Maguire, J; et al. Lack of Association between Human Herpesvirus and Vestibular Schwannoma: Analysis of 121 Cases. OTOLARYNGOLOGY-HEAD AND NECK SURGERY 152:513-517(2015).
Shapiro, IM; Kolev, VN; et al. Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship. SCIENCE TRANSLATIONAL MEDICINE 6:-(2014).
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