Pde10a

  • Official Full Name

    PDE10A phosphodiesterase 10A

  • Overview

    The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal;transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP;and cGMP to the corresponding nucleoside 5 monophosphate, but has higher affinity for cAMP, and is more efficient;with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
  • Synonyms

    PDE10A; phosphodiesterase 10A; cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A; phosphodiesterase 10A1 (PDE10A1); dJ416F21.1 (phosphodiesterase 10A); HSPDE10A; FLJ11894; FLJ25677;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDE10A-1610H Active Recombinant Human PDE10A, GST-tagged Sf9 Insect Cell GST
Human PDE10A-440H Recombinant Human Phosphodiesterase 10A, GST-tagged Sf9 Insect Cell GST
Human PDE10A-3355HCL Recombinant Human PDE10A 293 Cell Lysate HEK293 N/A
Human PDE10A-304H Recombinant Human PDE10A Protein, His-tagged E.coli His
Human PDE10A13721H Recombinant Human PDE10A (14-779) Protein
Human PDE10A-160H Recombinant Human PDE10A protein, GST-tagged E. coli GST
Human PDE10A2233H Recombinant Human PDE10A (449-789) Protein
Mouse Pde10a-438M Recombinant Mouse Phosphodiesterase 10A, GST-tagged Sf9 Insect Cell GST
Mouse PDE10A-12544M Recombinant Mouse PDE10A Protein Mammalian Cell His
Mouse PDE10A-6580M-B Recombinant Mouse PDE10A Protein Pre-coupled Magnetic Beads HEK293
Mouse PDE10A-6580M Recombinant Mouse PDE10A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pde10a-4739M Recombinant Mouse Pde10a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PDE10A-4324R Recombinant Rat PDE10A Protein Mammalian Cell His
Rat Pde10a-439R Recombinant Rat Phosphodiesterase 10A, GST-tagged Sf9 Insect Cell GST
Rat PDE10A16839R Recombinant Rat PDE10A (452-794) Protein
Rat PDE10A-3984R-B Recombinant Rat PDE10A Protein Pre-coupled Magnetic Beads HEK293
Rat PDE10A-3984R Recombinant Rat PDE10A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PDE10A-11324Z Recombinant Zebrafish PDE10A Mammalian Cell His
Kit-2043 PDE10A Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Pde10a Related Articles

Pde10a involved in several pathways and played different roles in them. We selected most pathways Pde10a participated on our site, such as G alpha (s) signalling events, GPCR downstream signaling, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pde10a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
G alpha (s) signalling eventsCGA;RAMP1;RXFP2B;GHRH;CRHB;RLN2;SCT;POMCB;PTHLHA
GPCR downstream signalingOBSCN;KALRN;RLN3A;RGS21;OXGR1;GPR132;GNA13B;S1PR5B;ADM2
HemostasisAPOBB.1;ANXA2A;MAFGB;F13A1A.1;CENPE;HBG2;JAM2B;SERPINA1L;S100A10
Nitric oxide stimulates guanylate cyclaseKCNMA1;PDE10A;KCNMB1;KCNMB2
Platelet homeostasisATP2B1B;KCNMA1;SLC8A2A;KCNMB2;PDE10A;ATP2B3A;APOER2;KCNMB1
Purine metabolismNT5E;POLD2;NME1-NME2;POLR3E;POLR2B;NPR1A;GMPR2;ATIC;PRPS1A
Signal TransductionFST;OR56A1;ARHGEF3;NPHP4;GPR37B;RGS4;APLNR;GDI2;IFT172

Pde10a has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, 3,5-cyclic-nucleotide phosphodiesterase activity, cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pde10a itself. We selected most functions Pde10a had, and list some proteins which have the same functions with Pde10a. You can find most of the proteins on our site.

Function Related Protein
3,5-cyclic-GMP phosphodiesterase activityPDE6G;PDE6C;PDE5A;PDE6B;PDE9A;PDE6H;PDE11A;PDE6A;PDE10A
3,5-cyclic-nucleotide phosphodiesterase activityPDE4D;PDE9A;PDE8A;PDE3B;PDE6D;PDE8B;PDE5AB;PDE10A;PDE5A
cAMP bindingPDE4A;PRKAR1B;BVES;PDE11A;PDE4D;HCN2;PDE10A;PDE2A;CNMPD1
cGMP bindingCNGA2;PDE6G;CNGA4;PDE2A;PDE11A;PRKG2;PDE5A;CNGA1;CNGA5
cGMP-stimulated cyclic-nucleotide phosphodiesterase activityPDE11A;USB1;PDE2A;TDP2B;PDE10A
drug bindingDRD3;PPARA;PDXK;CHRNB3;NAMPT;CHRNA7;DRD1;GRIK1;GLRB
metal ion bindingARID2;VPS29;ZC3H10;RPL37A;PRKCBP1L;FTR82;NRXN3;RNF17;AGAP2

Pde10a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pde10a here. Most of them are supplied by our site. Hope this information will be useful for your research of Pde10a.

WDR3

Guez-Barber, D; Fanous, S; et al. FACS purification of immunolabeled cell types from adult rat brain. JOURNAL OF NEUROSCIENCE METHODS 203:10-18(2012).
Charych, EI; Jiang, LX; et al. Interplay of Palmitoylation and Phosphorylation in the Trafficking and Localization of Phosphodiesterase 10A: Implications for the Treatment of Schizophrenia. JOURNAL OF NEUROSCIENCE 30:9027-9037(2010).
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