PDE6A

  • Official Full Name

    phosphodiesterase 6A, cGMP-specific, rod, alpha

  • Overview

    This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008]
  • Synonyms

    PDE6A; phosphodiesterase 6A, cGMP-specific, rod, alpha; PDEA; RP43; CGPR-A; rod cGMP-specific 3,5-cyclic phosphodiesterase subunit alpha; PDE V-B1; GMP-PDE alpha; cGMP phosphodiesterase alpha subunit; rod photoreceptor cGMP phosphodiesterase alpha subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDE6A-1529H Active Recombinant Human PDE6A, GST-tagged Sf9 Insect Cell GST 31 aa-end
Human PDE6A-1613H Active Recombinant Human PDE6A, GST-tagged Sf9 Insect Cell GST 31-end
Human PDE6A-30821TH Recombinant Human PDE6A Insect Cell N/A 827 amino acids
Human PDE6A-1604H Recombinant Human PDE6A, His-tagged E.coli His 1-90aa
Human PDE6A-352H Recombinant Human PDE6A Mammalian Cell His
Human PDE6A-1613 Recombinant Human PDE6A protein, GST-tagged Insect Cell GST 31-end
Human PDE6A-3347HCL Recombinant Human PDE6A 293 Cell Lysate HEK293 N/A
Human PDE6A-3817H Recombinant Human PDE6A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PDE6A-1879H Recombinant Human PDE6A protein, GST-tagged E.coli GST 1-90 aa
Human PDE6A-3817H-B Recombinant Human PDE6A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PDE6A-3349R Recombinant Rhesus monkey PDE6A Protein, His-tagged Mammalian Cell His
Rhesus Macaque PDE6A-3167R Recombinant Rhesus Macaque PDE6A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PDE6A-3167R-B Recombinant Rhesus Macaque PDE6A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PDE6A-1650Z Recombinant Zebrafish PDE6A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PDE6A involved in several pathways and played different roles in them. We selected most pathways PDE6A participated on our site, such as Purine metabolism, Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismADSL;NME2B.1;POLA2;GMPS;PDE2A;APRT;PDE7A;NME1-NME2;DCK
PhototransductionCNGA1;GUCA1B;CALM3A;RCV1;PDE6A;CALML5;GNB1;GRK7A;SAGA

PDE6A has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE6A itself. We selected most functions PDE6A had, and list some proteins which have the same functions with PDE6A. You can find most of the proteins on our site.

Function Related Protein
3,5-cyclic-GMP phosphodiesterase activityPDE6H;PDE6G;PDE10A;PDE5A;PDE11A;PDE6C;PDE6A;PDE6B;PDE9A
metal ion bindingETFDH;PPP4CA;ZFP689;ZSCAN4D;FTR72;THAP8;PPP1CA;ECEL1;ZNF598

PDE6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE6A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE6A.

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