• Official Full Name

    phosphodiesterase 6B, cGMP-specific, rod, beta

  • Background

    Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE),;resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell.;PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the;beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night;blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PDE6B; phosphodiesterase 6B, cGMP-specific, rod, beta; PDEB; rod cGMP-specific 3,5-cyclic phosphodiesterase subunit beta; congenital stationary night blindness 3; autosomal dominant; CSNB3; rd1; RP40; GMP-PDE beta; rod cGMP-phosphodiesterase beta-subunit;
    • Type:
    • Cell & Tissue Lysates
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDE6B-3346HCL Recombinant Human PDE6B 293 Cell Lysate HEK293 N/A
    Human PDE6B-3295H Recombinant Human PDE6B protein, His-tagged E.coli His
    Human PDE6B-1530H Active Recombinant Human PDE6B (Active), GST-tagged Sf9 Insect Cell GST
    Human PDE6B-150H Recombinant Human PDE6B protein, GST-tagged E. coli GST
    Mouse PDE6B-12559M Recombinant Mouse PDE6B Protein Mammalian Cell His
    Mouse PDE6B-6588M Recombinant Mouse PDE6B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse PDE6B-6588M-B Recombinant Mouse PDE6B Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein

    PDE6B involved in several pathways and played different roles in them. We selected most pathways PDE6B participated on our site, such as Purine metabolism, Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    PDE6B has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE6B itself. We selected most functions PDE6B had, and list some proteins which have the same functions with PDE6B. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-GMP phosphodiesterase activityPDE6G;PDE11A;PDE10A;PDE9A;PDE6A;PDE5A;PDE6H;PDE6B;PDE6C
    metal ion bindingZNF302;CCDC71L;ZNF384L;PPP2CB;ZFP354A;CHEK2;HAND2;RBM27;MARCH5L

    PDE6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE6B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE6B.

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