Creative BioMart to Present at Discovery on Target 2023 | Sep. 25-28, 2023 | Booth number #302 Learn More

PDE6B

Official Full Name

phosphodiesterase 6B, cGMP-specific, rod, beta
Background

Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE),;resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell.;PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the;beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night;blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

PDE6B; phosphodiesterase 6B, cGMP-specific, rod, beta; PDEB; rod cGMP-specific 3,5-cyclic phosphodiesterase subunit beta; congenital stationary night blindness 3; autosomal dominant; CSNB3; rd1; RP40; GMP-PDE beta; rod cGMP-phosphodiesterase beta-subunit;

Type:
Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species :
Human
Mouse

Source :
E. coli
E.coli
HEK293
Mammalian Cell
Sf9 Insect Cell

Tag :
GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PDE6B-3346HCL	Recombinant Human PDE6B 293 Cell Lysate	HEK293	N/A	Inquiry
Human	PDE6B-3295H	Recombinant Human PDE6B protein, His-tagged	E.coli	His	$319.00 / 25ug
Human	PDE6B-1530H	Active Recombinant Human PDE6B (Active), GST-tagged	Sf9 Insect Cell	GST	Inquiry
Human	PDE6B-150H	Recombinant Human PDE6B protein, GST-tagged	E. coli	GST	Inquiry
Mouse	PDE6B-12559M	Recombinant Mouse PDE6B Protein	Mammalian Cell	His	Inquiry
Mouse	PDE6B-6588M	Recombinant Mouse PDE6B Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug
Mouse	PDE6B-6588M-B	Recombinant Mouse PDE6B Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PDE6B involved in several pathways and played different roles in them. We selected most pathways PDE6B participated on our site, such as Purine metabolism, Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	NUDT9;ENTPD8;AMPD3B;PDE8B;ADKB;ADSS;TWISTNB;PRPS1;RRM2B
Phototransduction	GNAT3;GUCY2F;RGS9A;PDE6G;GNAT2;CALML5;RCVRN;RCVRNA;CALM4

PDE6B has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE6B itself. We selected most functions PDE6B had, and list some proteins which have the same functions with PDE6B. You can find most of the proteins on our site.

Function	Related Protein
3,5-cyclic-GMP phosphodiesterase activity	PDE6G;PDE11A;PDE10A;PDE9A;PDE6A;PDE5A;PDE6H;PDE6B;PDE6C
metal ion binding	ZNF302;CCDC71L;ZNF384L;PPP2CB;ZFP354A;CHEK2;HAND2;RBM27;MARCH5L

PDE6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE6B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE6B.