Recombinant Human PIK3C2A, His-tagged

• Cat.No.: PIK3C2A-1715H
• Product Overview: Recombinant Human PIK3C2A protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-338aa
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: PIK3C2A phosphoinositide-3-kinase, class 2, alpha polypeptide [ Homo sapiens ]
• Official Symbol: PIK3C2A
• Synonyms: PIK3C2A; phosphoinositide-3-kinase, class 2, alpha polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; PI3K C2alpha; PI3K-C2alpha; PI3K-C2-alpha; ptdIns-3-kinase C2 subunit alpha; phosphoinositide 3-kinase-C2-alpha; C2-containing phosphatidylinositol kinase; CPK; PI3-K-C2A; MGC142218; PI3-K-C2(ALPHA); DKFZp686L193
• Gene ID: 5286
• mRNA Refseq: NM_002645
• Protein Refseq: NP_002636
• MIM: 603601
• UniProt ID: O00443
• Chromosome Location: 11p15.5-p14
• Pathway: 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; Clathrin derived vesicle budding, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem; Insulin Signaling, organism-specific biosystem
• Function: 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4-phosphate 3-kinase activity; ATP binding; binding; nucleotide binding; phosphatidylinositol 3-kinase activity; phosphatidylinositol binding; phosphotransferase activity, alcohol group as a

Reviews

10/22/2020

The PIK3C2A protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.

08/23/2020

Its versatility and reliability make it an indispensable asset for scientists seeking to explore the complexities of various biological systems.

01/27/2019

Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.

Q&As

Can targeting PIK3C2A have potential applications in immunotherapy?

PIK3C2A inhibitors may enhance the efficacy of immunotherapy by modulating immune cell function and overcoming resistance to immune checkpoint inhibitors in cancer.

What strategies are being explored to target PIK3C2A for the treatment of insulin resistance and diabetes?

Research is focusing on developing small molecule inhibitors and gene therapy approaches to modulate PIK3C2A activity as a potential therapeutic strategy for diabetes.

What role does PIK3C2A play in the development of neurological disorders?

PIK3C2A has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, suggesting its potential as a target for disease-modifying therapies.

What are the potential therapeutic applications of targeting PIK3C2A in cancer treatment?

Targeting PIK3C2A may lead to the development of novel anticancer therapies, including small molecule inhibitors and monoclonal antibodies.

How does PIK3C2A protein contribute to cell signaling pathways?

PIK3C2A is involved in the PI3K/Akt/mTOR signaling pathway, which regulates cell growth, proliferation, and survival, making it an attractive target for therapeutic intervention.