PXN

  • Official Full Name

    paxillin
  • Overview

    This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the;extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been;described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well;as physiological properties (PMID:9054445).
  • Synonyms

    PXN;paxillin;FLJ16691

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • His
  • S
  • Trx
  • T7
  • Non
  • DDK
  • Myc
  • GST
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PXN-2083H Recombinant Human PXN, His-tagged E.coli Human His 1-267aa
PXN-029H Recombinant Human PXN Protein, Trx, His and S-tags-tagged E.coli Human His&S&Trx
PXN-030H Recombinant Full Length Human PXN Protein, His-tagged E.coli Human His Full L.
Pxn-1874M Recombinant Mouse Pxn protein, His & T7-tagged E.coli Mouse His&T7 Lys347~Asp578
Pxn-1875R Recombinant Rat Pxn protein, His & T7-tagged E.coli Rat His&T7 Ser327~Phe568
PXN-29060TH Recombinant Human PXN E.coli Human Non 203 amino acids
PXN-4856R Recombinant Rat PXN Protein Mammalian Cells Rat His
PXN-6542C Recombinant Chicken PXN Mammalian Cells Chicken His
PXN-2651HCL Recombinant Human PXN 293 Cell Lysate HEK293 Human Non
PXN-001H Recombinant Human paxillin Protein, His-tagged E.coli Human His 59-274aa
PXN-01H Recombinant Human PXN Protein, His-tagged E.coli Human His 2-557 a.a.
PXN-1138H Recombinant Human PXN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
PXN-2413H Recombinant Human Paxillin, GST-tagged E.coli Human GST 356-558 a.a.
PXN-4515R Recombinant Rat PXN Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
PXN-4515R-B Recombinant Rat PXN Protein Pre-coupled Magnetic Beads HEK293 Rat
Pxn-5268M Recombinant Full Length Mouse Pxn Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc Full L.
PXN-6123H Recombinant Human PXN Protein (Lys201-Lys461), N-His tagged E.coli Human His Lys201-Lys461

    Involved Pathway

    PXN involved in several pathways and played different roles in them. We selected most pathways PXN participated on our site, such as Chemokine signaling pathway,VEGF signaling pathway,Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PXN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Viral carcinogenesis HIST1H2BB,EGR3,ATP6V0D1,RAC1,CDC20,HDAC7A,PKM,ATP6V0D2,CREB5,HIST1H2BK
    Proteoglycans in cancer FZD3,MMP2,MAPK13,WNT8A,AKT2,CAMK2A,PRKCG,RAC1,HSPB2,PRKACG
    Leukocyte transendothelial migration PIK3R5,RAP1B,ITGB1,MYL9,THY1,RHOH,MMP9,NOX3,CLDN22,CLDN11
    Bacterial invasion of epithelial cells ILK,CDC42,ARPC5L,PTK2,SEPT1,CAV1,ITGA5,SEPT9,PIK3CG,SHC1
    Chemokine signaling pathway RHOA,CXCR2,PREX1,WASL,SHC3,PIK3R3,CXCR5,AKT1,CCL26,GM1987
    Regulation of Actin Cytoskeleton RAC3A,ROCK1,GSN,Itgam&Itgb2,PIP4K2A,MOS,MYL7,ITGAX,HRAS,ITGB3B
    VEGF signaling pathway PTK2AA,PTGS2A,RAC1A,RAC1,PLA2G4D,MAPKAPK2A,PPP3R1B,PRKCBA,NRAS,PRKCG
    Focal adhesion Itga10&Itgb1,ROCK2,Reln,COL5A2,TLN2A,CAV1,SOS1,ITGA2B,IBSP,TNC

    Protein Function

    PXN has several biochemical functions, for example, BH4 domain binding,beta-catenin binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PXN itself. We selected most functions PXN had, and list some proteins which have the same functions with PXN. You can find most of the proteins on our site.

    Function Related Protein
    zinc ion binding DIDO1,NEIL3,LHX4,TRIM55,VDRB,ZDHHC15B,TRIM65,TRIM69,MARCH6,SPRYD5
    protein binding FAM192A,SUSD2,CFH,TMEM100,ARMC9,PKIA,FAM133A,CSF2RA,CMTM5,ITGA2B
    integrin binding CYR61,ADAM23,VWF,FBLN1,THBS4,CTGFA,ADAM17,ITGB5,ADAMTS5,COL5A1
    vinculin binding ACTN1,SYNM,DMD,C22orf28,TLN1,CTNNA1,NRAP,SORBS3,DAG1
    protein kinase binding Fert2,PRKACA,SLC12A5,IL31RA,PLK1,VRK1,NR4A3,SMAD3,ACTA2,SLC12A7
    beta-catenin binding GLI3,TCF7L1B,PSEN1,BCL9,SMAD7,DACT1,TCF7L2,PTPRU,GRIP1,SOX17

    Interacting Protein

    PXN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PXN here. Most of them are supplied by our site. Hope this information will be useful for your research of PXN.

    PTK2;PTPN11;Sorbs1

    PXN Related Signal Pathway

    Resources

    References

    Ask a Question for All PXN Products

    Required fields are marked with *

    My Review for All PXN Products

    Required fields are marked with *