PXN

  • Official Full Name

    paxillin

  • Overview

    This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the;extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been;described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well;as physiological properties (PMID:9054445).
  • Synonyms

    PXN; paxillin; FLJ16691;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • Trx|His|S
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PXN-2083H Recombinant Human PXN, His-tagged E.coli His 1-267aa
Human PXN-29060TH Recombinant Human PXN E.coli N/A 203 amino acids
Human PXN-029H Recombinant Human PXN Protein, Trx, His and S-tags-tagged E.coli Trx/His/S
Human PXN-030H Recombinant Human PXN Protein, His-tagged E.coli His
Human PXN-2651HCL Recombinant Human PXN 293 Cell Lysate HEK293 N/A
Human PXN-1138H Recombinant Human PXN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PXN-2413H Recombinant Human Paxillin, GST-tagged E.coli GST
Human PXN-6123H Recombinant Human PXN Protein (Lys201-Lys461), N-His tagged E.coli N-His Lys201-Lys461
Human PXN-01H Recombinant Human PXN Protein, His-tagged E.coli His
Mouse Pxn-1874M Recombinant Mouse Pxn protein, His & T7-tagged E.coli His/T7 Lys347~Asp578 (Accession # Q8VI36)
Mouse Pxn-5268M Recombinant Mouse Pxn Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PXN-4856R Recombinant Rat PXN Protein Mammalian Cell His
Rat Pxn-1875R Recombinant Rat Pxn protein, His & T7-tagged E.coli His/T7 Ser327~Phe568 (Accession # Q66H76)
Rat PXN-4515R Recombinant Rat PXN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PXN-4515R-B Recombinant Rat PXN Protein Pre-coupled Magnetic Beads HEK293
Chicken PXN-6542C Recombinant Chicken PXN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PXN Related Research Area
  • PXN Related Signal Pathway

PXN involved in several pathways and played different roles in them. We selected most pathways PXN participated on our site, such as Chemokine signaling pathway, VEGF signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PXN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayCCL7;CXCL6;AKT2;GNG7;FGR;PTK2;GNB1;CCL20;CXCL13
VEGF signaling pathwayPPP3CC;SH2D2A;CDC42;PPP3CA;MAPK3;AKT2;NFATC2;AKT2L;HRASA
Focal adhesionCDC42L2;LAMC2;COL1A1A;RHOAB;RHOAA;KDRL;MYLK2;PDPK1;XIAP
Leukocyte transendothelial migrationNCF2;GNAI1;CLDN1;MYLPF;PIK3R3;VCL;OCLN;CLDN2;CLDN11
Regulation of actin cytoskeletonSCINLA;PAK1;MYLK4;FGF16;ITGAL;PPP1R12B;RHOAA;ITGAM;MYLPF
Bacterial invasion of epithelial cellsCLTA;CBLC;BCAR1;VCL;SHC4;ARPC5L;DNM2;HCLS1;SEPT3
Viral carcinogenesisTRAF2;EP300;HDAC7A;PKM2;TBPL1;HIST1H4K;RB1;HIST1H4N;PIK3R5
Proteoglycans in cancerWNT5B;PIK3CB;CD44;MAPK3;SRC;FZD5;PTCH1;MET;FAS

PXN has several biochemical functions, for example, BH4 domain binding, beta-catenin binding, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PXN itself. We selected most functions PXN had, and list some proteins which have the same functions with PXN. You can find most of the proteins on our site.

Function Related Protein
BH4 domain binding
beta-catenin bindingRORA;BCL9L;PTPRU;CHD8;APC;CXADR;AXIN2;CTNNA1;SLC9A3R1
integrin bindingCTGFB;ILK;ITGA6;THBS4;DMP1;MFGE8;NISCH;EDIL3;FBLN1
protein bindingMAPT;CD160;A1CF;COL18A1;SPIN1;ASB3;NUDT4;UBE2U;ARF4
protein kinase bindingDAXX;STX1B;HNRNPA0;KCNA5;GDF3;SLC12A4;TOM1L1;PAK2;CDKN2A
vinculin bindingPXN;ACTN1;TLN1;DMD;CTNNA1;SYNM;NRAP;SORBS3;C22orf28
zinc ion bindingZNF259;MEP1A.2;KMT2A;CPDB;CPA6;NR2F6B;RSPRY1;KDM5A;RNF125

PXN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PXN here. Most of them are supplied by our site. Hope this information will be useful for your research of PXN.

PTK2; PTPN11; Sorbs1

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