RARA

  • Official Full Name

    retinoic acid receptor, alpha

  • Overview

    This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
  • Synonyms

    RARA; retinoic acid receptor, alpha; retinoic acid receptor alpha; NR1B1; RAR; RAR-alpha; retinoic acid receptor, alpha polypeptide; nuclear receptor subfamily 1 group B member 1; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear recep;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RARA-31053TH Recombinant Human RARA, His-tagged E.coli His
Human RARA-31319TH Recombinant Human RARA, His-tagged E.coli His
Human RARA-31320TH Recombinant Human RARA, His-tagged E.coli His
Human RARA-2510H Recombinant Human RARA, His-tagged Insect Cell His
Human RARA-1130H Recombinant Human RARA, Ligand Binding Domain Sf9 Insect Cell N/A
Human RARA-190H Recombinant Human Retinoic Acid Receptor, Alpha, His-tagged E.coli His
Human RARA-1131H Recombinant Human RARA, Ligand Binding Domain, GST-tagged Sf9 Insect Cell GST
Human RARA-170H Recombinant Human RARA protein, GST/His-tagged E.coli GST/His
Human RARA-111H Recombinant Human Retinoic acid receptor alpha, GST-tagged Sf9 Insect Cell GST
Human RARA-2515HCL Recombinant Human RARA 293 Cell Lysate HEK293 N/A
Human RARA-2516HCL Recombinant Human RARA 293 Cell Lysate HEK293 N/A
Human RARA-301471H Recombinant Human RARA protein, GST-tagged E.coli GST Leu420-Pro462
Human RARA-6141H Recombinant Human RARA Protein (Ser68-Glu173), His tagged E.coli His Ser68-Glu173
Human RARA-2840H Recombinant Human RARA protein, His-tagged E.coli His 83-424 aa
Mouse RARA-13932M Recombinant Mouse RARA Protein Mammalian Cell His
Mouse Rara-5686M Recombinant Mouse Rara protein, His & T7-tagged E.coli His/T7 Val237~Pro459 (Accession # P11416)
Mouse RARA-7423M Recombinant Mouse RARA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse RARA-7423M-B Recombinant Mouse RARA Protein Pre-coupled Magnetic Beads HEK293
Rat Rara-5687R Recombinant Rat Rara protein, His & T7-tagged E.coli His/T7 Val237~Pro459 (Accession # Q499N1)
Chicken RARA-6105C Recombinant Chicken RARA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RARA Related Articles
  • RARA Related Research Area

RARA involved in several pathways and played different roles in them. We selected most pathways RARA participated on our site, such as Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with RARA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pathways in cancerSTAT3;Fgf15;SLC2A1;EGLN1;EP300;TRAF2;BIRC2;PIAS2;FOS
Transcriptional misregulation in cancerRUNX2;SSX1;WT1;NCOR1;MEF2C;HMGA2;CLSTN2;HIST1H3E;PPARG
Acute myeloid leukemiaCCND1;TCF7;MYC;AKT1;PIK3CG;EIF4EBP1;HRAS;PIK3CB;NFKB1

RARA has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, alpha-actinin binding, chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RARA itself. We selected most functions RARA had, and list some proteins which have the same functions with RARA. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II regulatory region sequence-specific DNA bindingNFIL3;PHF21A;ATF5A;MNT;NR1I3;AASS;SOHLH1;ATF4B1;HES6
alpha-actinin bindingALMS1;XIRP2;KCNA5;LRRC10;MAGI1;ADORA2A;DAG1;PPARG;PKD2L1
chromatin DNA bindingZIC2;SMAD3;VAX2;APEX1;CLOCK;MED1;PPARGC1A;EZH2;THRA
enzyme bindingNCOA1;PARP4;UGT1A3;PEX7;SNX12;HINFP;WWOX;DDC;MSH2
protein bindingGPRASP2;N4BP2L2;NUB1;EIF4EBP2;NOX5;MC5R;UBC;ADCYAP1R1;FBXW9
protein domain specific bindingTWIST1;NFASC;CNTROB;ZNF521;KCNN2;CEP68;POU2F2;PTPN11;ESRRA
protein heterodimerization activityH3F3B;SNX1;DRD1;SMAD1;UGT1A1;ADRA2A;CENPW;BCL11A;SPTAN1
protein kinase A bindingRARA;AKAP13;RPS3;AKAP4;AKAP5;DACT1;AKAP6;AKAP14;AKAP7
protein kinase B bindingTRAF6;CCDC88A;APPL1;BCL10;RARA;PDE3B;PINK1;ANKRD2;BAD
receptor bindingWNT7A;CD58;PTK2BB;TMED1;NUDT19;LYN;NRG2B;PANX1;CRTAM
retinoic acid bindingRARA;CRABP2;CRABP1B;SERPINA5;LRAT;UGT1A7;LCN12;CYP26B1;UGT1A3
retinoic acid receptor activityESRRG;RARGA;RARAA;RARAB;RXRA;RARG;RARB;RARGB;NR1D4B
retinoic acid-responsive element bindingZFP536;RARA;RXRA
steroid hormone receptor activityRARAA;PGR;NR0B1;NR2F1;ESRRG;PPARDB;HNF4A;NR1H4;RARGB
transcription coactivator activityYAF2;HIF3A;SOX10;KMT2E;KAT5;NEUROG3;VGLL1;RBPMS;MCIN
transcription corepressor activityZNF136;ALX1;HDAC3;NSD1;AES;CBX4;SUFU;DNMT3B;CBFA2T2
transcription factor activity, sequence-specific DNA bindingMYF6;TAL1;HIST1H2AH;MEOX1;SMAD2;TEAD1A;ZNF256;ZSCAN4D;MESPBA
transcription factor bindingNR0B2A;CDK9;TAF7;PELP1;FOS;KEAP1;PPRC1;ARID5A;NKX2-1
zinc ion bindingZDHHC1;CA15A;SKI;PHF20L1;BBOX1;ZCCHC10;Car12;TRIM8;ADAM8

RARA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RARA here. Most of them are supplied by our site. Hope this information will be useful for your research of RARA.

RXRG; RXRA; MED1

Yin, CC; Jain, N; et al. Identification of a Novel Fusion Gene, IRF2BP2-RARA, in Acute Promyelocytic Leukemia. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK 13:19-22(2015).
Mueller, GA; Maleki, SJ; et al. Identification of Maillard reaction products on peanut allergens that influence binding to the receptor for advanced glycation end products. ALLERGY 68:1546-1554(2013).
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