Active Recombinant Human RARA Protein, GST tagged

• Cat.No.: RARA-1131H
• Product Overview: Recombinant Human Retanoic Acid Receptor alpha ligand binding domain (amino acids 176-462; NP_ 000955), GST-tagged, expressed in insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 176-462 aa
• Description: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
• Form: 50 mM potassium phosphate (pH 8.0), 150 mM KCl, 0.5 mM EDTA, 0.02% Triton X–100, 10 mM DTT and 20% Glycerol.
• Molecular Mass: 59.5 kDa. Calculated from the protein sequence(s).
• Purity: 95% as determined by a SDS-PAGE gel stained with SimplyBlue SafeStain.
• Storage: If properly stored in its original container at -80 centigrade, this product is guaranteed for 6 months from date of purchase. Mix gently, do not vortex. Do NOT make single use aliquots.
• Concentration: 0.50 mg/mL total protein as measured using the Bradford protein assay with BSA as a standard. Calculated 8,400 nM.
• Shipping: Dry ice

Gene Information

• Gene Name: RARA retinoic acid receptor alpha [ Homo sapiens (human) ]
• Official Symbol: RARA
• Synonyms: RARA; retinoic acid receptor alpha; RAR; NR1B1; RARalpha; retinoic acid receptor alpha; PML-DDX5-RARA fusion; PML-DDX5-RARA fusion protein; RAR-alpha; TTMV/RARA fusion; TTMV/RARA fusion protein; nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; retinoic acid receptor, alpha polypeptide
• Gene ID: 5914
• mRNA Refseq: NM_000964
• Protein Refseq: NP_000955
• MIM: 180240
• UniProt ID: P10276