| Official Full Name | Rho-associated, coiled-coil containing protein kinase 1 |
| Background | ROCK-1, a 160 kDa small-GTP-effector protein, is a serine/threonine kinase involved in the induction of focal adhesions and stress fibers, and can play a major role in vascular smooth muscle contraction, malignant cell transformation, tumor invasion and m |
| Synonyms | ROCK1; Rho-associated, coiled-coil containing protein kinase 1; rho-associated protein kinase 1; p160ROCK; p160-ROCK; Rho kinase; p160 ROCK-1; renal carcinoma antigen NY-REN-35; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coil |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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ROCK1 involved in several pathways and played different roles in them. We selected most pathways ROCK1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROCK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | SLC8A1; ATF4; PRKCE; MEF2A; ITPR1; MYLK4; SLC25A5; PLCB2; PDE5A; GUCY1B3 |
| cAMP signaling pathway | PDE4D; GRIN2A; NPR1; PLN; GHRL; SOX9; NFKB1; DRD1A; F2R; EP300 |
| Chemokine signaling pathway | PRKACG; CXCR2; PREX1; GM13306; IKBKB; CDC42; GRK7; AKT1; GNB1; PIK3R1 |
| Sphingolipid signaling pathway | PLCB2; PPP2R2A; SMPD1; MAPK10; BCL2; MAPK9; MAPK13; PIK3R1; PDPK1; FCER1A |
| Vascular smooth muscle contraction | GNA15.4; PRKACAB; MYH11; CALML3; KCNMB1; PLA2G4D; NPR1A; PLCB1; MAP2K2A; PRKCG |
| TGF-beta signaling pathway | TGFB1A; TGFB2; BMPR1BA; SMAD3; BMP2B; PPP2CA; ACVR2A; BAMBIB; BAMBI; RHOAD |
| Axon guidance | KIF4; MYL9; MARK3; SLIT1; EFNB2; EGF; PEA15A; ROCK1; ACTR3; ABLIM1 |
| Focal adhesion | PPP1CBL; ARHGAP35; PPP1CAB; MAPK9; VEGFB; IGF1RB; PDGFC; PAK7; SEPP1; PTK2 |
| Platelet activation | TLN1; APBB1IP; FYN; SNAP23; PLCG2; PIK3R2; PRKCZ; COL27A1; MAPK1; RHOA |
| Leukocyte transendothelial migration | MYL5; PIK3R3; CDC42; ACTG1; CLDN20; PXN; RAP1A; ROCK1; ESAM; BCAR1 |
| Regulation of actin cytoskeleton | DIAP1; RAC3; FGF16; RHOAB; RAC2; ITGA8; IQGAP2; FGF13B; APC2; SCINLA |
| Oxytocin signaling pathway | PIK3CG; Adcy4; GNAI1; CAMKK1; CAMK1D; PLA2G4D; CALML3; NFATC2; ITPR3; MEF2C |
| Pathogenic Escherichia coli infection | CDC42; ARPC5L; TUBB; ITGB1; NCL; ARHGEF2; NCK1; ACTB; WAS; LY96 |
| Shigellosis | MAPK13; BTRC; U2AF1L4; SRC; ELMO2; RELA; MAPK8; RAC1; ROCK2; ACTG1 |
| Salmonella infection | MAPK8; DYNC1I1; IL-8; PKN1; MAPK12; KLC4; PKN3; MAPK10; MYH9; CDC42 |
| Pathways in cancer | PLCB3; Shh; PLD1; GLI3; RB1; ITGA2B; AXIN1; CUL2; FGF1; TFG |
| Proteoglycans in cancer | MMP9; STAT3; FZD8; MAPK1; TFAP4; CBLB; FN1; WNT5A; THBS1; CBL |
| MicroRNAs in cancer | CCNE2; SPRY2; Casp3; HRAS; PLCG1; TPM1; MAP2K2; FOXP1; STAT3; ABCB1 |
ROCK1 has several biochemical functions, for example, ATP binding, GTP-Rho binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ROCK1 itself. We selected most functions ROCK1 had, and list some proteins which have the same functions with ROCK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SLFNL1; TRPM4; UBE2D1A; RIPK1L; INO80; CHEK2; MYH6; DDX25; MYLK4; DHX32A |
| GTP-Rho binding | STXBP6L; ROCK2B; CDC42EP3; EXOC1; CDC42EP1B; CDC42EP4A; TNFAIP1; ROCK1; TRIOBP; NET1 |
| metal ion binding | OBSCN; BCO2; ADAM25; RUFY4; DMRT3A; PRUNE2; ZNF493; PGCP; CYP2AA3; GBGT1 |
| protein binding | RRAGA; NDE1; CD247; FCN2; NR1H4; CXorf48; IDE; HSPB11; MEN1; MID1 |
| protein kinase activity | STK24; GUCY2C; MAPKAPK2B; TBRG4; ERBB4A; CDK1; LRRK2; RPS6KB2; RIPK1L; SGK2B |
| protein serine/threonine kinase activity | SBK3; PHKG2; ACVR1BA; SRPK3; TTN; DCLK3; PHKG1A; MAPK8B; LIMK1; CDK12 |
ROCK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROCK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROCK1.
RHOA; MAGEB4; LMO2; FAM124A; C6orf165; POLR3C; MYBPH
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