ROCK1

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ROCK1

Official Full Name Rho-associated, coiled-coil containing protein kinase 1
Background ROCK-1, a 160 kDa small-GTP-effector protein, is a serine/threonine kinase involved in the induction of focal adhesions and stress fibers, and can play a major role in vascular smooth muscle contraction, malignant cell transformation, tumor invasion and m
Synonyms ROCK1; Rho-associated, coiled-coil containing protein kinase 1; rho-associated protein kinase 1; p160ROCK; p160-ROCK; Rho kinase; p160 ROCK-1; renal carcinoma antigen NY-REN-35; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coil
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ROCK1-1794H Recombinant Human ROCK1 protein, GST-tagged E.coli GST
    Human ROCK1-1480H Recombinant Human ROCK1 (Active), GST-tagged Sf9 Insect Cell GST
    Human ROCK1-552H Recombinant Human ROCK1 Mammalian Cell His
    Human ROCK1-76H Recombinant Human ROCK1 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Mouse ROCK1-14369M Recombinant Mouse ROCK1 Protein Mammalian Cell His
    Mouse Rock1-15M Recombinant Mouse Rock1 protein, His-tagged E.coli His
    Rat ROCK1-5094R Recombinant Rat ROCK1 Protein Mammalian Cell His
    Rhesus Macaque ROCK1-3951R Recombinant Rhesus monkey ROCK1 Protein, His-tagged Mammalian Cell His
    Chicken ROCK1-4314C Recombinant Chicken ROCK1 Mammalian Cell His
    Zebrafish ROCK1-8173Z Recombinant Zebrafish ROCK1 Mammalian Cell His

    ROCK1 involved in several pathways and played different roles in them. We selected most pathways ROCK1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ROCK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway CALML5; FXYD2; PPP3R1; IRS2; SLC8A1; PPP3CA; NOS3; ROCK1; AGTR1B; NPR2
    cAMP signaling pathway CNGA1; GNAI2; PLD1; GRIN3B; ROCK1; HTR4; RYR2; RRAS2; FXYD2; NFKB1
    Chemokine signaling pathway SHC3; GRK1; FOXO3; CCR5; CXCL9; MAP2K1; DOCK2; VAV1; WASL; CXCR6
    Sphingolipid signaling pathway LOC100328615; PPP2R2B; SGMS2; FYN; LASS1; PPP2R1B; MAPK3; SPHK2; PPP2R5E; NRAS
    Vascular smooth muscle contraction ITPR3; GNA15.1; CALM3A; BRAF; PPP1R12C; ACTG2; PRKACA; PLCB2; PPP1R14A; PLA2G2E
    TGF-beta signaling pathway INHBA; BMP7A; BMP6; TGFBR1A; SMAD3A; ID2B; CHD; BAMBI; CUL1A; CHRD
    Axon guidance NRTN; ARPC1A; DOCK1; DUSP6; JAK1; SEMA3AB; RHOAE; DPYSL5A; RND1L; EFNA1B
    Focal adhesion EGFRA; MAPK8B; RAC3; ITGA1; LAMB1; THBS4B; AKT2L; SHC1; LAMC3; SHC3
    Platelet activation Adcy4; PLCB4; FERMT3; MAPK13; PIK3R2; FCGR2A; PRKACG; FGA; PRKCZ; MAPK3
    Leukocyte transendothelial migration NOX3; MYL7; MYL9; MMP9; CDH5; CXCL12; RAC2; ACTN4; PIK3CG; CLDN9
    Regulation of actin cytoskeleton MYL10; FGF18A; MYL2; RHOAA; FGF21; ITGA2B; FGF13; PFN1; HRAS; PAK6
    Oxytocin signaling pathway PLCB4; CACNG7; HRAS; NPR2; PRKAA2; PIK3R3; CAMK2B; MYLK2; CACNB3; CACNA2D2
    Pathogenic Escherichia coli infection ROCK2; CLDN1; TUBA1A; TLR5; TUBAL3; CD14; EZR; ABL1; TUBA1C; CDC42
    Shigellosis U2AF1; NFKBIB; WASF1; UBE2D2; ELMO2; MAPK10; RIPK2; MAPK9; VCL; DIAPH1
    Salmonella infection CXCL8B.3; TJP1; PFN3; NOS2; RAB7; RAC1A; KLC1A; KLC2; TLR5; WASF1
    Pathways in cancer FGF18; PIK3CG; RASSF5; GNG5; CXCR4; PTCH2; LPAR2; DAPK2; CCNA1; PTGER1
    Proteoglycans in cancer SDC2; PRKCG; TFAP4; VTN; TNF; CAMK2D; MAP2K2; RPS6KB2; FZD2; FZD9
    MicroRNAs in cancer TP53; PTGS2; MAP2K2; SOX4; IGF2BP1; FZD3; PLAU; RHOA; PRKCB; CCNE1

    ROCK1 has several biochemical functions, for example, ATP binding, GTP-Rho binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ROCK1 itself. We selected most functions ROCK1 had, and list some proteins which have the same functions with ROCK1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TBCK; MYH10; PBK; MAPK15; STK32C; ABCC1; CCT6A; GAK; ACTR1; DDX53
    GTP-Rho binding RTKN2B; NET1; CDC42EP4A; KCTD13; CDC42EP2; ROCK1; ROCK2A; TNFAIP1; RTKN; CDC42EP5
    metal ion binding CYGB1; EGR2B; CLCA1; ARHGEF1A; APLF; NUAK1; PPM1K; CYP19A1A; Acsm2a; ZNF223
    protein binding TP53RK; IL15RA; EIF2AK3; C11orf65; ERCC6; RQCD1; SNAPC5; BMF; TOPORS; CCT3
    protein kinase activity NEK1; HIPK3B; MAP4K1; PKMYT1; LTK; FYNB; CDK11A; EPHB4A; SRPK1; SCYL1
    protein serine/threonine kinase activity LATS1; PRKACAB; PRKDC; MAP3K14; SIK2A; TTBK1; STK17A; RPS6KB2; CSNK1D; CDK14

    ROCK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ROCK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ROCK1.

    RHOA; MAGEB4; LMO2; FAM124A; C6orf165; POLR3C; MYBPH

    Ashley, N; Jones, M; et al. Rapidly derived colorectal cancer cultures recapitulate parental cancer characteristics and enable personalized therapeutic assays. JOURNAL OF PATHOLOGY 234:34-45(2014).
    Rentala, S; Chintala, R; et al. Atorvastatin inhibited Rho-associated kinase 1 (ROCK1) and focal adhesion kinase (FAK) mediated adhesion and differentiation of CD133(+)CD44(+) prostate cancer stem cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 441:586-592(2013).

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