RPS6KA4

  • Official Full Name

    ribosomal protein S6 kinase, 90kDa, polypeptide 4

  • Overview

    This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
  • Synonyms

    RPS6KA4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; MSK2; RSK-B; ribosomal protein S6 kinase alpha-4; RSKB; S6K-alpha-4; ribosomal protein kinase B; ribosomal protein S6 kinase alpha 4; 90 kDa ribosomal protein S6 kinase 4; mitogen- and stress-activated protein kinase 2; nuclear mitogen- and stress-activated protein kinase 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RPS6KA4-162H Active Recombinant Human RPS6KA4(2-end) Protein, N-His-tagged Sf21 His 2-end
Human RPS6KA4-163H Unactive Recombinant Human RPS6KA4(2-end) Protein, N-His-tagged Sf21 His 2-end
Human RPS6KA4-2434H Recombinant Human RPS6KA4, His-tagged E.coli His 1-302aa
Human RPS6KA4-29913TH Recombinant Human RPS6KA4, His-tagged E.coli His
Human RPS6KA4-2160HCL Recombinant Human RPS6KA4 293 Cell Lysate HEK293 N/A
Human RPS6KA4-4448HF Active Recombinant Full Length Human RPS6KA4 Protein, GST-tagged Insect (sf21) GST 1-772
Human RPS6KA4-2049H Recombinant Human RPS6KA4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse RPS6KA4-14496M Recombinant Mouse RPS6KA4 Protein Mammalian Cell His
Mouse Rps6ka4-1062M Recombinant Mouse Ribosomal Protein S6 Kinase, Polypeptide 4, GST-tagged Sf9 Insect Cell GST
Mouse RPS6KA4-7793M-B Recombinant Mouse RPS6KA4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Rps6ka4-843M Recombinant Mouse Rps6ka4 protein, His-tagged Insect cells C-His 1-773aa
Mouse Rps6ka4-5610M Recombinant Mouse Rps6ka4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Rps6ka4-7543M Recombinant Mouse Rps6ka4 protein, His&Myc-tagged Insect cells N-His&C-Myc 1-773aa
Mouse RPS6KA4-7793M Recombinant Mouse RPS6KA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Rps6ka4-1732M Recombinant Mouse Rps6ka4 protein, His-tagged E.coli N-His 1-773aa
Rhesus Macaque RPS6KA4-4029R Recombinant Rhesus monkey RPS6KA4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RPS6KA4-3846R-B Recombinant Rhesus Macaque RPS6KA4 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RPS6KA4-3846R Recombinant Rhesus Macaque RPS6KA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RPS6KA4-6718Z Recombinant Zebrafish RPS6KA4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

RPS6KA4 involved in several pathways and played different roles in them. We selected most pathways RPS6KA4 participated on our site, such as MAPK signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPAK2B;MAP2K2;RAF1A;GNA12;RPS6KA3B;CACNA1B;PRKACG;CDC42L;HSP70
TNF signaling pathwayNFKB1;PGAM5;MMP14;MAPK9;CXCL3;LIF;BIRC3;MAP2K7;BAG4

RPS6KA4 has several biochemical functions, for example, ATP binding, histone kinase activity (H3-S10 specific), magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA4 itself. We selected most functions RPS6KA4 had, and list some proteins which have the same functions with RPS6KA4. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSTK32B;ACSS1;ACVRL1;DHX37;CLCN6;MAT1A;HELLS;HELZ2;AKT3
histone kinase activity (H3-S10 specific)RPS6KA5;VRK1;RPS6KA4
magnesium ion bindingMAP3K5;ABL1;RPS6KA1;CLYBL;IMPA1;SIK2;ATP8B3;PPM1AB;ATP10A
mitogen-activated protein kinase p38 bindingRPS6KA4;PRMT1;SPAG9;NFATC1;TAB1
protein bindingSKAP1;ARF5;BLM;SOX1;SOX7;SLC30A1;EIF2B3;MIF;FGFR1OP
protein serine/threonine kinase activitySTK39;MAPK14A;NEK7;ACVR1BA;PDK3;TSSK4;BMPR2B;MYO3B;CAMK1DB
ribosomal protein S6 kinase activityALPK2;RPS6KB2;RPS6KA3A;RPS6KA6;RPS6KA4;RPS6KA3B;RPS6KB1;RPS6KA3;RPS6KA1

RPS6KA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA4.

MAPK14; MAPK3; pi3p; linkable sunitinib analogue; purvalanol b; midostaurin; SNW1; CDC37; CDC5L

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