RXRA
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Official Full Name
RXRA retinoid X receptor, alpha
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Synonyms
RXRA; retinoid X receptor, alpha; retinoic acid receptor RXR-alpha; NR2B1; nuclear receptor subfamily 2 group B member 1; retinoid X nuclear receptor alpha; FLJ00280; FLJ00318; FLJ16020; FLJ16733; MGC102720;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- Mammalian cells
- Sf9 Insect Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
RXRA involved in several pathways and played different roles in them. We selected most pathways RXRA participated on our site, such as PPAR signaling pathway, PIK-Akt signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RXRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PPAR signaling pathway | ME1;MMP1;ACSBG1;ACSL1A;SLC27A2;PPARD;PPARA;GK2;MMP1A |
| PIK-Akt signaling pathway | PKN2;RAC1;IFNA4;MLST8;ITGA2;PTK2;GNG4;PIK3R3;FGF7 |
| Thyroid hormone signaling pathway | MED17;PIK3CA;PIK3R2;NOTCH3;THRA;ACTG1;ESR1;THRB;DIO2 |
| Adipocytokine signaling pathway | PRKAG2;G6PC3;PPARGC1A;ACSL1B;AKT1;PCK2;POMC;ACSL4;STAT3 |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFS1;PPARA;NDUFA7;NDUFB10;NDUFS4;MLXIPL;SREBF1;UQCRFS1;UQCRB |
| Bile secretion | SLC22A1;ABCC2;SLC4A4;ABCB11;LDLR;ADCY9;ADCY7;SLCO1B2;Abcb1b |
| Hepatitis C | IFNA7;MAPK13;MAPK8;MAPK3;CLDN20;Ifna15;TRAF6;TP53;IFNA17 |
| Pathways in cancer | AHA-1;FGF17;NCOA4;RAD51;RAC2;PLCB1;PTGER2;TRAF1;FZD6 |
| Transcriptional misregulation in cancer | DOT1L;ITGAM;ETV6;IL1R2;FUS;ASPSCR1;HPGD;HIST1H3G;HIST1H3E |
| Thyroid cancer | PAX8;CCND1;TPR;CDH1;RET;RXRG;TCF7;PPARG;TPM3 |
| Small cell lung cancer | COL4A1;PIK3CA;LAMB4;BCL2L1;LAMA3;TRAF3;TRAF4;RXRB;PTEN |
| Non-small cell lung cancer | ERBB2;MAP2K2;RASSF5;RARB;PIK3CA;RB1;AKT2;PIK3R2;AKT1 |
RXRA has several biochemical functions, for example, 9-cis retinoic acid receptor activity, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RXRA itself. We selected most functions RXRA had, and list some proteins which have the same functions with RXRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 9-cis retinoic acid receptor activity | RXRA;RXRB;RXRG;RXRGA;RXRAB |
| DNA binding | HIST2H2L;CERS4;ZNF530;TIGD5;DEAF1;TBL1XR1;ZBTB12;BRD4;DACH2 |
| RNA polymerase II regulatory region sequence-specific DNA binding | MYOD1;ARHGAP35;DMRT2;NME2;ATF4B1;ETV3;RXRG;GLIS1;ETV6 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | PTGER3;Ar;PPARDB;RXRB;NR5A1A;NR1I3;NR1H3;RORAB;AHR2 |
| chromatin DNA binding | MED1;SLAMF7;RELA;INSM1A;H2AFZ;MYOD1;HDAC3;RARA;MYOG |
| enzyme binding | BCL10;AKT1;XRCC1;MDM2;NOTCH1;SORT1;HOXA9;N4BP2L2;NPM2 |
| protein binding | RB1;NTS;HELZ2;OAZ3;SOX30;IL36RN;BCL6;PHF23;TEX14 |
| protein complex binding | ARRB2;MYO7A;ING2;WRN;RBX1;YWHAB;NR0B2;VAMP2;GNB4 |
| protein domain specific binding | BASP1;HGS;ARFIP2A;GABRR1;ERCC1;SFN;STRN4;HIST2H4;ICA1 |
| protein heterodimerization activity | NTSR1;SUPT5H;CASP8;HIST1H2BD;CEBPB;MAPK4;BAK1;IRAK2;CLNS1A |
| retinoic acid receptor activity | RARGA;RARA;RXRA;RARGB;ESRRG;RARG;RARAA;RARB;RARAB |
| retinoic acid receptor binding | HMGA1-RS1;PRAMEF10;PRAME;PRMT2;NSD1;PRAMEF1;LRIF1;MED25;HMGA1 |
| retinoic acid-responsive element binding | RXRA;ZFP536;RARA |
| sequence-specific DNA binding | ARX;GRHL1;LBX1A;HOXA5A;EMX1;LMX1BA;PKNOX1.1;DMRT2A;NKX2.3 |
| steroid hormone receptor activity | RORAB;NR2C2;NR5A2;ESR2A;RORCA;ESR2B;PPARAA;THRB;RXRAA |
| transcription coactivator activity | TAF9;ESRRB;GMEB1;RFXAP;PER2;JUND;NR2C2;GATA3;SOX17 |
| transcription factor activity, sequence-specific DNA binding | NR4A2B;ZIM3;PA2G4A;PRRX2;FOXC1A;RUNX2B;MESPBA;TSC22D4;DMRT1 |
| contributes_to transcription factor activity, sequence-specific DNA binding | NFE2L2A;NKX2;SMAD2;SMAD4;TAF10;GATA4;RXRA;HNRNPAB;TAF6 |
| contributes_to transcription regulatory region DNA binding | NFYC;TAF1;NR1H3;TCF12;HDAC5;TCF3;HDAC4;HAND1;RXRA |
| vitamin D receptor binding | RUNX2B;RXRA;THRAP3;TAF11;MED1;MED24;MED16;TAF7;MED17 |
| contributes_to vitamin D response element binding | VDRA;VDRB;RXRA;VDR |
| zinc ion binding | OTUD7B;TRIM28;QPCT;PGLYRP2;TCF19;UNKL;LMX1A;WTIP;Car12 |
RXRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RXRA here. Most of them are supplied by our site. Hope this information will be useful for your research of RXRA.
RARA; NCOA1; MED25; sulindac; PIK3R1
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