Recombinant Full Length Human RXRA Protein, C-Flag-tagged

• Cat.No.: RXRA-654HFL
• Product Overview: Recombinant Full Length Human RXRA Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 50.6 kDa
• AA Sequence: MDTKHFLPLDFSTQVNSSLTSPTGR GSMAAPSLHPSLGPGIGSPGQLHSP ISTLSSPINGMGPPFSVISS PMGPHSMSVPTTPTLGFSTGSPQLS SPMNPVSSSEDIKPPLGLNGVLKVP AHPSGNMASFTKHICAICGD RSSGKHYGVYSCEGCKGFFKRTVRK DLTYTCRDNKDCLIDKRQRNRCQYC RYQKCLAMGMKREAVQEERQ RGKDRNENEVESTSSANEDMPVERI LEAELAVEPKTETYVEANMGLNPSS PNDPVTNICQAADKQLFTLV EWAKRIPHFSELPLDDQVILLRAGW NELLIASFSHRSIAVKDGILLATGL HVHRNSAHSAGVGAIFDRVL TELVSKMRDMQMDKTELGCLRAIVL FNPDSKGLSNPAEVEALREKVYASL EAYCKHKYPEQPGRFAKLLL
  RLPALRSIGLKCLEHLFFFKLIGDT PIDTFLMEMLEAPHQMTTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Adipocytokine signaling pathway, Non-small cell lung cancer, Pathways in cancer, PPAR signaling pathway, Small cell lung cancer, Thyroid cancer

Gene Information

• Gene Name: RXRA retinoid X receptor alpha [ Homo sapiens (human) ]
• Official Symbol: RXRA
• Synonyms: NR2B1; RXRalpha; RXR-alpha
• Gene ID: 6256
• mRNA Refseq: NM_002957.6
• Protein Refseq: NP_002948.1
• MIM: 180245
• UniProt ID: P19793