SOCS2

  • Official Full Name

    suppressor of cytokine signaling 2

  • Overview

    Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
  • Synonyms

    SOCS2; suppressor of cytokine signaling 2; CIS2; Cish2; SOCS 2; SSI 2; SSI2; STAT induced STAT inhibitor 2; STATI2; CIS-2; STAT induced STAT inhibitor-2; STAT-induced STAT inhibitor 2; STAT-induced STAT inhibitor-2; cytokine-inducible SH2 protein 2; suppressor of cytokine signaling-2; SSI-2; SOCS-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOCS2-2871H Recombinant Human SOCS2, His-tagged E.coli His 1-198aa
Human SOCS2-1581HCL Recombinant Human SOCS2 293 Cell Lysate HEK293 N/A
Human SOCS2-6672H Recombinant Human SOCS2 Protein (Met1-Val198), N-His tagged E.coli N-His Met1-Val198
Human SOCS2-3514H Recombinant Human SOCS2 protein, GST-tagged E.coli GST 1-198aa
Rat SOCS2-5664R Recombinant Rat SOCS2 Protein Mammalian Cell His
Rat Socs2-690R Recombinant Rat Socs2 Protein, His-tagged E.coli His Met1~Val198
Rat SOCS2-5323R-B Recombinant Rat SOCS2 Protein Pre-coupled Magnetic Beads HEK293
Rat SOCS2-5323R Recombinant Rat SOCS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SOCS2-4401R Recombinant Rhesus monkey SOCS2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque SOCS2-4217R Recombinant Rhesus Macaque SOCS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque SOCS2-4217R-B Recombinant Rhesus Macaque SOCS2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish SOCS2-6428Z Recombinant Zebrafish SOCS2 Mammalian Cell His
Chicken SOCS2-6109C Recombinant Chicken SOCS2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • SOCS2 Related Signal Pathway

SOCS2 involved in several pathways and played different roles in them. We selected most pathways SOCS2 participated on our site, such as Jak-STAT signaling pathway, Insulin signaling pathway, Prolactin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOCS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Jak-STAT signaling pathwayGM13305;IL22RA1;PTPN2;PRLRA;Ifna11;FHL1B;HRASB;Ifna15;IFNA13
Insulin signaling pathwaySREBF1;CALM1;PPP1R3B;PCK1;CALM1A;CALM2;PRKCZ;FLOT1;PRKAB1B
Prolactin signaling pathwayMAPK11;MAPK1;PIK3CB;PIK3R1;MAPK12;STAT5A;SOCS2;PIK3CG;STAT3
Type II diabetes mellitusIRS1;HK1;PKM;PKM2;PIK3R3;SLC2A2;PIK3CG;MTOR;PDX1

SOCS2 has several biochemical functions, for example, JAK pathway signal transduction adaptor activity, SH3/SH2 adaptor activity, growth hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOCS2 itself. We selected most functions SOCS2 had, and list some proteins which have the same functions with SOCS2. You can find most of the proteins on our site.

Function Related Protein
JAK pathway signal transduction adaptor activitySH2B2;SOCS2
SH3/SH2 adaptor activityLAT;GRAP;SH3BGRL;SRC;SLA2;SH2B2;CD28;PTPN11;ARHGAP4
growth hormone receptor bindingJAK2;JAK1;SOCS2;Gh;GH1;TYK2
insulin-like growth factor receptor bindingGNAS;IGF3;PIK3R1;YWHAG;IRS1;SHC1;IGF2;REN;INSL4
protein bindingABCF1;BRMS1;SUB1;CSRP3;TJAP1;BDKRB1;CBY1;LTBR;FAM124A

SOCS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOCS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOCS2.

TCEB1; MET; KIT; PLA2G1B; EPOR; BMI1; ARFIP2; TPD52; Tceb1; GHR

Research Area

Related articles

Hu, J; Lou, DH; et al. LPS Regulates SOCS2 Transcription in a Type I Interferon Dependent Autocrine-Paracrine Loop. PLOS ONE 7:-(2012).
Gilli, F; Navone, ND; et al. Loss of Braking Signals During Inflammation A Factor Affecting the Development and Disease Course of Multiple Sclerosis. ARCHIVES OF NEUROLOGY 68:879-888(2011).
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