TRADD
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Official Full Name
TNFRSF1A-associated via death domain -
Overview
Apoptosis mediated by death factors like FasL and TNF-alpha involves the formation of a death-inducing signaling complex (DISC) to their respective receptors (1). Upon ligand activation to their receptors, Fas and TNF-R1 associate with death domain (DD) c -
Synonyms
TRADD;TNFRSF1A-associated via death domain;tumor necrosis factor receptor type 1-associated DEATH domain protein;Hs.89862;TNFR1-associated death domain protein;tumor necrosis factor receptor-1-associated protein;tumor necrosis factor receptor type 1 associated death domain protein;MGC11078
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- HEK293
- His
- Non
- T7
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| TRADD-3383H | Recombinant Human TRADD protein, His-tagged | E.coli | Human | His | 1-312 aa | |
| TRADD-3384H | Recombinant Human TRADD protein, His-tagged | E.coli | Human | His | Met61~Leu297 | |
| TRADD-29977TH | Recombinant Human TRADD, His-tagged | E.coli | Human | His | Full L. 1-150 a.a. |
|
| TRADD-9147Z | Recombinant Zebrafish TRADD Protein, His tagged | HEK293 | Zebrafish | His |
|
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| TRADD-826HCL | Recombinant Human TRADD 293 Cell Lysate | HEK293 | Human | Non |
|
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| Tradd-1415M | Recombinant Mouse Tradd protein, His & T7-tagged | E.coli | Mouse | His&T7 | Ser21~Leu259 |
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| Tradd-1416R | Recombinant Rat Tradd protein, His & T7-tagged | E.coli | Rat | His&T7 | Asp24~Glu261 |
|
| TRADD-4420H | Recombinant Human TRADD protein, GST-tagged | E.coli | Human | GST | 1-312aa |
|
| TRADD-6657H | Recombinant Human TRADD Protein (Met61-Leu297), N-His tagged | E.coli | Human | His | Met61-Leu297 |
|
Involved Pathway
TRADD involved in several pathways and played different roles in them. We selected most pathways TRADD participated on our site, such as NF-kappa B signaling pathway,Sphingolipid signaling pathway,Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRADD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | TRP53,SRF,SKP2,ATF4,HIST1H2BP,HIST1H4F,GTF2A2,NFKB1,HDAC1,MRPS18B |
| Adipocytokine signaling pathway | IKBKB,STAT3,AKT2L,PPARAB,ADIPOR2,ACSL4B,ACSL4,SLC2A1,TNFRSF1A,PRKAG2A |
| NF-kappa B signaling pathway | BTK,CFLAR,CARD11,BCL2A1,GM1987,BIRC3,MAP3K7IP3,TNFSF13B,TRAF2,ZAP70 |
| Epstein-Barr virus infection | AKT2,ITGAL,POLR1C,SPN,HLA-DRB5,RBPJ,PSMD7,HLA-DQA2,GTF2E1,MAP2K4 |
| Tuberculosis | H2-AA,TGFB3,MRC2,HLA-DQA1,HLA-DRA,PIK3C3,IRAK1,CAMK2A,BAD,ITGAX |
| RIG-I-like receptor signaling pathway | MAPK12,DDX58,MAPK12A,MAPK11,Ifna15,IKBKG,DAK,NFKB1,CASP10,Ifna11 |
| Hepatitis C | PIK3CD,RXRA,PPP2R2A,PDPK1,PPARA,CLDN6,PIK3CB,TNF,NFKB1,IFNA21 |
| TNF signaling pathway | TRAF1,MAPK12,MAGI2,IL6,TAB2,TRAF3,RPS6KA5,CASP8,MAP3K14,CXCL1 |
| Sphingolipid signaling pathway | PIK3R3,RHOA,PLD2,PPP2R3C,TNFRSF1A,SPHK2,NOS3,SGPL1,TRAF2,GAB2 |
Protein Function
TRADD has several biochemical functions, for example, binding, bridging,death domain binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRADD itself. We selected most functions TRADD had, and list some proteins which have the same functions with TRADD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tumor necrosis factor receptor binding | TRAF3,TNFSF8,TNFSF4,FASLG,CD40LG,EDA,TNFB,TRAF6,TNFSF10L4,TNFSF13 |
| protein binding | MALL,CHP,USP28,KLF12,TNPO1,RDM1,AP3M1,WDR77,ECHS1,PIK3IP1 |
| signal transducer activity | OLFCS2,GNAO1B,GPR126,TICAM1,RGS6,GPR34A,VIPR1B,TAAR14G,CC2D1A,OLFR186 |
| identical protein binding | COMMD1,APLP2,FXR2,CLPP,ASS1,TP73,ETNPPL,OAT,FNBP1,DYNLT1C |
| binding, bridging | PDCD6,GAS6 |
| kinase binding | SLC2A1,PPP2R5A,CHIA,RASGRP3,DLG1,JAKMIP3,BTG1,JAKMIP2,C2orf44,LDHB |
| protein complex binding | UGT1A6A,UFD1L,RNF40,ADM2,PGAM5,EPCAM,NDUFA4,MYO7A,VHLL,MTAP1B |
| death domain binding | DAP,DAP1B,RIPK1,DAPL1,CRADD |
Interacting Protein
TRADD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRADD here. Most of them are supplied by our site. Hope this information will be useful for your research of TRADD.
TNFRSF1A;TRAF2
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References
- Hu, R; Du, QM; et al. Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment. FEBS LETTERS 588:401-407(2014).
- Hirsch, B; von der Wall, E; et al. RIP1 expression is necessary for CD30-mediated cell death induction in anaplastic large-cell lymphoma cells. LABORATORY INVESTIGATION 93:677-689(2013).
