Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid cancer NCOA4,RET,PPARG,MAPK1,RXRA,KRAS,TCF7L2,TCF7,CCND1,PAX8
    Small cell lung cancer BIRC2,RXRB,BIRC8,RELA,LAMA4,MAX,TRAF6,LAMA3,PTGS2,TRAF3
    Bladder cancer DAPK3,DAPK1,RPS6KA5,CCND1,RASSF1,MAPK1,E2F1,UPK3A,SRC,ERBB2
    Wnt signaling pathway DVL3A,PRKACBB,PPP3CCB,CCND2,FZD3B,SFRP1A,PRKCB,FBXW11A,SFRP5,CHD8
    Melanoma FGF7,FGF10,RAF1,ARAF,FGF11,FGF12,AKT2,NRAS,AKT1,FGF4
    Prostate Cancer BAD,PIK3CG,ATF4,PIK3CD,NFKBIA,PIK3CB,PDGFRA,KRAS,FGFR2,NKX3
    Proteoglycans in cancer PPP1CA,CAMK2G,CBLB,SMAD2,FLNA,STAT3,SDC4,PTPN6,WNT8B,ACTB
    Pancreatic cancer TGFBR2,CCND1,SMAD2,RAD51,STAT1,RB1,TGFBR1,CDC42,PIK3CB,RAF1
    Sphingolipid signaling pathway ROCK1,S1PR5,SGMS1,NRAS,MAPK12,MAPK8,PLCB3,RAC2,BID,NFKB1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    histone deacetylase regulator activity MAPK8,NCOR1,TP53
    protein kinase binding PRKAG1,CDH2,AP2A1,TEX14,AKAP5,CD36,SLC12A7,MAP2K7,LAX1,ELP2
    copper ion binding CP,DCT,MOXD1,HIST2H3A,S100A12,LOXL3B,P2RX2,MT3,P2RX4,F5
    transcription factor binding PPP1R13B,DNMT1,BCL10,NBN,SOX8,VDRA,E2F5,E2F2,IRF4,HMGA1-RS1
    enzyme binding DAXX,CD4,LAMP1,AXIN1,MAP2K7,NOXO1,HMOX1,UGT1A6B,PCBP2,SELS
    protein phosphatase binding JUP,HSP90B1,MVP,MAPK14,CDKN1B,CDH5,JAK1,JAK3,DLG4,ITPR1
    ATP binding MAP3K9,EPHB1,VSIG8B,MTPAP,DARS2,DNAH11,PIM2,CDK4,MAST4,ROCK2A
    transcription factor activity, sequence-specific DNA binding IRF3,KLF1,ZFP583,NFE2L1B,GPBP1,DMRTC2,KLF5,NFE2L2A,SLAMF7,INSM1B
    p53 binding AXIN1,TRIAP1,ZNF385A,TP73,DAXX,MDM2,TP53RK,PTTG1IP,SIRT1,SMARCA4

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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