Trp53
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Official Full Name
transformation related protein 53
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Synonyms
bbl; bfy; bhy; p44; p53; Tp53;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- Fc
- Avi
- Myc
- DDK
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Mouse | TRP53-17432M | Recombinant Mouse TRP53 Protein | Mammalian Cell | His |
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| Mouse | Trp53-5632M | Recombinant Mouse Trp53 protein, His-tagged | E.coli | His | Thr134~Asp387 |
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| Mouse | TRP53-9648M-B | Recombinant Mouse TRP53 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Trp53-6671M | Recombinant Mouse Trp53 Protein, Myc/DDK-tagged | HEK293T | Myc&DDK |
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| Mouse | Trp53-2140M | Recombinant Mouse Trp53 Protein, His-tagged | E.coli | His | Met1-Asp390 |
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| Mouse | TRP53-9648M | Recombinant Mouse TRP53 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Kit-2107 | p53 Transcription Factor Activity Assay Kit | Non |
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| Kit-1030 | Phospho-p53 (Ser15) Translocation Assay Kit (Cell-Based) | Non |
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| Kit-0642 | p53 Translocation Assay Kit (Cell-Based) | Non |
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| Kit-1037 | p53 Nuclear Translocation Assay Kit (Cell-Based) | Non |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | KCNA3;FGF22;PLA2G4F;FGFR2;MKNK2A;FGFR4;NFKB1;PPP3CB;CDC25B |
| Sphingolipid signaling pathway | FYN;LASS2;GNAI3;PDPK1;TRADD;PIK3CB;OPRD1;NFKB1;PRKCZ |
| Cell cycle | NIPBLA;SMC3;NUMA1;CDK1;NEK2;NCAPH;CCP110;VRK1;ANAPC7 |
| p signaling pathway | GADD45AB;ATM;SESN2;CCNB3;COP1;ZMAT3;CCNB2;BBC3;TSC2 |
| PIK-Akt signaling pathway | TLR2;IFNA16;VEGFC;BCL2L1;IFNA7;LAMA1;FGFR1;PKN3;IFNA1 |
| Apoptosis | DBNL;FASLG;TNFRSF1A;IRAK4;STK24;HIST1H1D;CASP9;PKP1;NFKBIAA |
| Wnt signaling pathway | PRKACG;FZD8;CAMK2B;WNT1;PPP3CC;NFATC4;WNT4;PLCB3;FZD9 |
| Neurotrophin signaling pathway | PIK3R5;MAPK1;ABL1;HRAS;TRAF6;SORT1;SHC3;MAP3K5;IRAK4 |
| Thyroid hormone signaling pathway | PIK3CB;THRA;MAPK1;MED12L;PIK3R2;PLCD4;MED12;MED14;PRKACG |
| Amyotrophic lateral sclerosis (ALS) | GRIN1;PRPH;NEFM;SLC1A2;PPP3CA;ALS2;NOS1;NEFH;BCL2 |
| Huntingtons disease | COX6B1;DNALC4;POLR2J2;TGM2;COX8C;COX7A1;SOD2;POLR2A;POLR2D |
| Hepatitis C | PPP2CA;PIK3R1;IL-8;PIK3CA;TRADD;IFNA13;EIF2AK1;CLDN18;RIPK1 |
| Hepatitis B | PRKCG;YWHAB;ELK1;STAT3;CXCL8;CREB3L1;PRKCB;RAF1;IFN-a |
| Measles | TNFSF10;BBC3;CD3E;IFNA21;DOK1;FCGR2B;MSN;TNFRSF10B;PIK3R3 |
| HTLV-I infection | IL1R1;VDAC2;APC2;XIAP;CD3D;NFKBIA;PRKACB;WNT4;ELK4 |
| Herpes simplex infection | IFNA4;CD74;PER3;CLOCKA;CCL5;IFNA14;IFNGR1;BMA2;ABCB3L1 |
| Epstein-Barr virus infection | PSMC5;TRAF3;Fcer2a;PSMD8;RIPK1;VIM;PSMC2;MAPK13;TAB2 |
| Pathways in cancer | TP53;ITGAV;WNT9A;GNG8;BCL2L1;KRAS;GSTP1;RALBP1;TRAF3 |
| Transcriptional misregulation in cancer | H3F3B;NR4A3;TFE3;SIX4;GRIA3;GOLPH3;MDM2;WHSC1;IL-8 |
| Viral carcinogenesis | SYK;HIST1H4N;POLB;TRP53;CREB3L3;HIST1H2BM;RHOA;HIST1H4B;STAT5A |
| Proteoglycans in cancer | PIK3R3;WNT7A;PRKCA;FZD7;PLAU;PAK1;IGF2;ITGA5;AKT1 |
| MicroRNAs in cancer | TNC;HRAS;RDX;ATM;FGFR3;IRS2;HMGA2;CDC25C;CCNG1 |
| Colorectal cancer | CASP9;ARAF;BIRC5;KRAS;TGFB2;PIK3R5;DCC;PIK3R2;Casp3 |
| Pancreatic cancer | AKT1;TGFA;PIK3CA;BCL2L1;TRP53;PIK3R3;AKT2;ARAF;RELA |
| Endometrial cancer | TRP53;ARAF;AKT1;PIK3CB;APC;TCF7;MAP2K2;HRAS;TCF7L2 |
| Glioma | SHC2;KRAS;SOS1;ARAF;AKT1;CCND1;PDGFRA;PIK3R5;RB1 |
| Prostate cancer | NFKB1;KRAS;IKBKG;PIK3CA;MAP4K1;NDRG1;RELA;ATF4;IKBKB |
| Thyroid cancer | RXRG;CCDC6;RET;MAPK1;NRAS;BRAF;TRP53;RXRB;TPM3 |
| Basal cell carcinoma | FZD6;SUFU;FZD9;WNT6;FZD7;WNT9A;APC2;TCF7L2;WNT2 |
| Melanoma | BAD;AKT2;FGFR1;PDGFA;FGF12;FGF14;FGF4;NRAS;FGF21 |
| Bladder cancer | MAP2K2;FGFR3;SRC;UPK3A;DAPK2;MMP1A;E2F3;MMP2;RASSF1 |
| Chronic myeloid leukemia | IKBKB;PIK3R1;BCL2L1;SMAD4;MAP2K1;NFKBIA;STAT5B;MAP2K2;PIK3CB |
| Small cell lung cancer | LAMB2;LAMC1;PTK2;RXRB;ITGAV;LAMA4;ITGA2;IKBKG;PIK3R2 |
| Non-small cell lung cancer | RXRB;STK4;MAPK1;EML4;PDPK1;SOS1;BAD;PIK3CA;FOXO3 |
| Central carbon metabolism in cancer | FGFR3;SIRT6;PKM2;G6PDX;PFKP;AKT2;AKT1;PIK3R5;HK1 |
Trp53 has several biochemical functions, for example, ATP binding, DNA binding, MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | SPATA5;ERN1;SPATA5L1;IRAK1;PAPSS2;RIPK1;MCM8;FIGNL1;KIF1C |
| DNA binding | ZBTB22;ZNF643;ZNF784;ZBED1;THAP5;CTCFL;SIX7;ZSCAN4C;HMGB3A |
| MDM2/MDM4 family protein binding | PPARA;RFWD3;CDKN2A;PSME3;CAV1;TRP53;CDK5RAP3 |
| RNA polymerase II core promoter sequence-specific DNA binding | ZNF277;SP3;GATA3;TFAP2B;SMYD3;ZFP335;RUNX2;HOXB3;FOS |
| RNA polymerase II regulatory region sequence-specific DNA binding | AASS;MYOG;ATF3;TFAP2E;CDX1A;ALX4;RXRB;TRPS1;BHLHA15 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | ETV2;NFIB;RUNX3;CC2D1A;SPDEF;FOXL1;SOX14;PLAGL2;TWIST1 |
| RNA polymerase II transcription factor binding | GATA1;MIXL1;GATA3;PITX2;TAL1;MTDH;GATA6;MTA2;GATA2A |
| chaperone binding | HSP104;HES1;DNAJB7;BAG3;CALR;DNAJB8;DNLZ;BAG5;ATP1A1 |
| chromatin binding | NCAPD3;KAT2B;NFKB2;TOP2B;SMAD4;BAHD1;WAC;TOX3;NCOA1 |
| copper ion binding | HAMP;SOD3A;COMMD1;S100U;MOXD1L;ADNP;CP;HEPHL1;HIST2H3A |
| core promoter sequence-specific DNA binding | SOX4;CHD2;PPARG;NFYA;SIRT1;ZNF750;PROX1;CRY1;ESR1 |
| damaged DNA binding | BRCA1;NEIL1;UNG;POLK;APEX1;GTF2H3;RAD23B;TDG;H2AFX |
| double-stranded DNA binding | RAD51;PRKDC;RAD51C;HNRNPDL;XRCC2;HLF;TARDBP;HMGB3;FBXO18 |
| enzyme binding | UGT1A6;HIST1H2AE;KDM1A;MSH2;CYP2E1;MAPK8;NOXO1;NOTCH3;HIST1H2AG |
| histone acetyltransferase binding | TAF7L;PCNA;SIRT2;MTF1;GLI3;EID1;NR4A3;CREB1;TAF7 |
| histone deacetylase regulator activity | TP53;MAPK8;NCOR1;TRP53 |
| identical protein binding | USP2;CBLL1;GLUL;ATG101;TP63;HOMER1;TTN;SUN2;NDC80 |
| metal ion binding | NOB1;ZNF804A;PDE9A;RPE65A;SMYD1B;ATP13A;ZDHHC3A;ACVR1B;POLK |
| p53 binding | PSME3;EHMT1;TRP63;ANKRD1;ZMAT4;TP53BP1;TRIM24;ZNF346;DAXX |
| protease binding | Serpina1c;SERPINA1A;ADAMTS4;LCN2;RYR1;INS;HSPD1;INS2;THAP5 |
| protein C-terminus binding | MLLT4;DST;ECM1;ERCC6;RAD51;PICK1;FBLN1;NIPBL;MKI67 |
| protein N-terminus binding | PEX5;RND2;NBN;ERCC4;SMARCC1;RPA2;ALG2;NCOA3;THAP7 |
| protein binding | FKBP7;CCDC155;SLAMF7;ELK3;ELP4;BUC;WLS;PRL;NARG2 |
| protein heterodimerization activity | SLC51B;HIST1H2B8;TAF8;GABRR1;NR2C2;PDX1;HIST2H2AA4;BCL11A;TLR2 |
| protein kinase binding | FOXM1;PTPN6;IBTK;H2AFY;SPRED1;BCAR1;HNRNPA0;PTK2;FGF19 |
| protein phosphatase 2A binding | ANKLE2;FOXO1;CTTNBP2NL;BCL2;RPS6KB1;SPHK1;MASTL;STRN;MAPT |
| protein phosphatase binding | RPA2;ITGA1;MAP3K5;JAK1;PIK3R1;EGFR;PARD3;STAT6;DLG3 |
| protein self-association | CTSC;ZNF496;AGTR1A;DVL2;PROSAPIP1;LDB1;AGXT;RSAD2;SYP |
| receptor tyrosine kinase binding | PTPN2;GAS6;SHC3;LRP4;SQSTM1;PCNA;ANGPT2A;NRG3;CPNE3 |
| sequence-specific DNA binding | DHARMA;FOXG1D;HOXB13;UBP1;HOXC13B;ESRRGB;BCL11AA;ESR2B;FOXO4 |
| transcription cofactor binding | FOXO3;KLF4;CHD6;TRP53 |
| transcription factor activity, sequence-specific DNA binding | HOXC6A;CREB5;FLI1A;RFX1A;TBPL2;HSF1;SMAD3B;ARNT2;SPI1B |
| transcription factor binding | SOX10;MYC;HAND1;MSX2;RORA;UBN1;PSMD10;IGHMBP2;TP73 |
| transcription regulatory region DNA binding | TAF7;PAX8;IKZF2;KDM1A;REST;SALL4;FOS;BCL11AA;SOX5 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | MZF1;WT1;ZFP750;NR4A1;PLAG1;RFX4;SOX12;ATF2;FOXI1 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MAFGB;REST;FOXF2;CSRNP1;DLX2;HSF2;FEZF2;IKZF3;MSGN1 |
| ubiquitin protein ligase binding | OTUB1;UBE2G1;YWHAE;FANCL;HM13;ERLIN2;PRKAR1A;TCEB2;AICDA |
Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.
lt_sv40; atp; Mdm2
Research Area
Related articles
Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).
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