Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Central carbon metabolism in cancer AKT1,MET,HK3,PIK3R5,SIRT6,PTEN,MTOR,MAP2K2,PIK3R3,HK2
    Measles RAB9A,IL2RA,CCND3,OAS1,IL4,Cd209g,EIF2AK3,NFKB1,NFKBIA,IL13
    MicroRNAs in cancer GLS2,IGF2BP1,PTEN,MMP16,ZEB1,TP53,RPS6KA5,MCL1,NOTCH4,PTGS2
    Neurotrophin signaling pathway NGFRAP1,NFKBIB,MAPK13,NTRK1,MATK,ARHGDIG,PIK3CD,PRKCD,YWHAE,SHC4
    Hepatitis B PCNA,CCNA1,NFATC1,MAPK10,IFIH1,MAP2K1,CREB3L2,IFNA7,DDX58,Casp3
    p signaling pathway TNFRSF10B,RFWD2,TSC2,PERP,PTENA,MDM2,GADD45AB,RPRMA,IGF1,GADD45AA
    Transcriptional misregulation in cancer PBX3,SIX4,DOT1L,ETV7,WHSC1,MLL1,MMP9,PRCC,PFTK1,LMO2
    Cell cycle ESPL1,MAU2,YWHAQ,GADD45AB,TGFB3,TSGA14,NEK7,NEK2,CSNK2A1,VRK1
    Herpes simplex infection H2-Q10,EIF2AK2,CDC34,IL6,PER1B,MAPK8B,HCFC1A,DDX58,TAF13,PKZ

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor activity, sequence-specific DNA binding ATF5,FOXQ2,FOXD4,RORB,UBN2B,STAT3,SREBF1,NR5A5,TAF13,FOXM1
    double-stranded DNA binding AIM2,ZNF638,HNRNPDL,SETMAR,RAD51C,RAD51L1,RAD51,KIN,MCM10,FEV
    p53 binding SMARCB1,RNF20,SETD7,BLM,USP10,ZNF385C,STK11,CREBBP,ZNF385B,EHMT1
    ATP binding HSPA5,MAT2AB,ATP1A1,C9orf96,MAP3K13,HSPA1A,ORC5,PTK2AB,MAPKAPK5,MAPKAPK2B
    copper ion binding SCO1,SNCA,RNF7,SLC11A2,ATP7B,COX11,ABP1,S100A12,F5,METTL17
    protein self-association SHANK3,AGA,ACHE,PCSK9,RSAD2,LDB1,TTN,ACVR2A,ZFP639,TNFAIP3
    identical protein binding FUS,CDC42,CIDEB,APOA1,ASS1,NDC80,LRRK1,RGMB,APIP,VPS4B
    metal ion binding ZDHHC3B,LNPA,ATP1A2A,ZNF664,CLPX,CASZ1,ACY1,MPO,EGR4,NR5A1A
    receptor tyrosine kinase binding HYAL2,SHC4,SHC3,ANGPT2A,PCNA,PLCG1,FIZ1,NCK1,PTPN2,PITPNM3

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All Trp53 Products

    Required fields are marked with *

    My Review for All Trp53 Products

    Required fields are marked with *