Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid cancer TPM3,NRAS,CCND1,PPARG,MAP2K1,BRAF,TCF7,MAPK1,RXRB,RXRA
    Measles HSPA1B,TNFRSF10C,STAT5A,NFKBIB,IFNGR2,IFNGR1,OAS3,GSK3B,TNFAIP3,IL1A
    Thyroid hormone signaling pathway MAPK3,PIK3R3,GSK3B,NOTCH1,EP300,RHEB,PRKCG,PLCG1,KAT2B,RCAN1
    Cell cycle SSNA1,TBC1D8,CENPL,RBL2,HDAC6,TMEM188,CNEP1R1,E2F5,RAD21,MCM10
    MicroRNAs in cancer UBE2I,DNMT3A,NOTCH4,CCNG1,FSCN1,ST14,MCL1,CDCA5,VEGFA,RASSF1
    Pancreatic cancer PIK3R2,STAT1,PIK3R1,SMAD3,RAC1,PIK3CB,PIK3R3,RB1,RAC2,TGFBR1
    Herpes simplex infection SP100,HLA-DQA1,TRAF6,HLA-DMB,HNRNPK,MAPK9,CDC34A,CASP3B,SRSF2,CRFB2
    Proteoglycans in cancer HSPG2,ERBB4,ANK2,PPP1R12A,PIK3R1,PLAU,HCLS1,HPSE,BRAF,ROCK2
    p signaling pathway SHISA5,CASP8,TP73,SFN,CCND3,CCNG2,PTENB,TP53,TNFRSF10B,GADD45AA

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HOXC6B,FOXJ1B,ZFP92,LIG4,UBP1,DBX1A,PUF60,RYBPB,DDX3X,TAF9
    histone deacetylase regulator activity NCOR1,MAPK8,TP53
    ATP binding ACTA2,PIP5K1A,TTLL4,NUBP1,KIF20A,MAPK12,XRCC5,MCCC1,TPK1,SARS
    protein heterodimerization activity UGT1A9,GCA,NPM1,UGT1A6,ITGB1B,USF2,AGTR1A,TXLNG,ADD2,CAPN2
    RNA polymerase II transcription factor binding TBX3,MTA2,CREBBP,CHST13,Ar,GATA2B,MEF2A,HCLS1,GFI1B,TBX20
    RNA polymerase II regulatory region sequence-specific DNA binding BARHL1A,RELB,ZNF8,ACTN4,ZBTB4,GATA2,CSDA,OSR2,ZNF584,GLIS1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding MYOG,PAX5,SOX11,SOX12,HOXD13,TFAP2E,NFATC2,FUBP3,SRF,CEBPB
    protein kinase binding CCND2,PARP1,PTPRR,DNAJC3,E2F1,ATF2,TRPV4,ERRFI1,PTPRJ,TPX2
    histone acetyltransferase binding GLI3,MEF2A,SIRT2,SP1,TAF7,ETS1,NR4A3,KAT2B,CITED2,EID1

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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