Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid cancer TPM3,MAP2K2,BRAF,TP53,HRAS,CCDC6,LEF1,PPARG,TFG,NRAS
    Glioma CAMK2A,PRKCB,SHC4,PRKCA,CCND1,CALML3,IGF1,BRAF,PIK3R2,IGF1R
    Thyroid hormone signaling pathway NOTCH1,MED30,MTOR,MED14,MDM2,PLCB1,MED1,ATP1B3,RCAN2,ATP1A2
    Pathways in cancer ARNT2,WNT7B,MAPK3,WNT9A,BIRC8,PAX8,GNG5,WNT5A,Fgf15,TGFB1
    PIK-Akt signaling pathway FGF14,GYS2,ITGB6,ATF4,LAMC1,CREB3L3,PIK3CD,CCND2,HGF,ITGA4
    Melanoma FGF4,TP53,MAPK1,PIK3R5,FGF20,MET,BAD,FGF10,FGF16,PDGFRA
    Viral carcinogenesis IRF3,GTF2H4,HIST1H2BO,HIST1H4A,HIST1H2BL,CCND1,HLA-A,HIST1H4B,RBL2,RANBP1
    Prostate Cancer SMARCC2,FGFR1,RB1,MAP4K1,SPRY1,ERBB2,PIK3R2,PDGFC,GSTP1,LEF1
    MicroRNAs in cancer CD44,FGFR3,FSCN1,GRB2,MDM2,IGF2BP1,CYP24A1,RASSF1,RPS6KA5,ABL1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor activity, sequence-specific DNA binding ZNF217,ZKSCAN17,RARAA,ZFP746,CNBP,FOS,MAFBB,DMBX1,ZNF668,ZBTB11
    protein phosphatase 2A binding STRN,SMG7,ENSAA,FOXO1,RPS6KB1,STRN4,MAPT,TP53,GRIN3A,BCL2
    identical protein binding SIAH1,SORD,NQO1,IAPP,NCL,LCK,STXBP1,DRG1,PNMA5,MRFAP1L1
    enzyme binding EIF4E,CTNNB1,POLB,USP22,KDM1A,BCHE,STUB1,HIST1H2AL,KAT8,PIAS3
    protein C-terminus binding AXIN1,VTA1,BLOC1S2,FOXN3,MED12,CAV3,TAX1BP3,ZBTB16,ABL1,DBNL
    RNA polymerase II regulatory region sequence-specific DNA binding DMRT2,IRF2,FOXD3,SOX13,ACTN4,ALX1,PHOX2B,ZFY2,ATF5,CDX1A
    protein self-association L1CAM,TRIM32,RSAD2,SLC2A1,PCSK9,ZNF496,ACVR2A,ZKSCAN17,CTSB,LDB1
    metal ion binding OBSCN,RORCB,ZNF831,EBF1,PDLIM3A,ZBED1,CAR7,RFK,ZNF362A,CYP1A
    p53 binding CHD8,NTRK3,BLM,CDKN2A,ZNF385D,TRIM24,ZFP346,ZMAT3,ZNF385C,ZNF385B

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All Trp53 Products

    Required fields are marked with *

    My Review for All Trp53 Products

    Required fields are marked with *