Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway TSC2,RHEB,NOTCH4,ATP1A3,GSK3B,KRAS,RAF1,EP300,TP53,ACTG1
    HTLV-I infection LTBR,NRP1,IL2RG,SMAD2,TSPO,VAC14,ZFP36,PRKACB,CCND3,LCK
    Small cell lung cancer RXRA,RELA,RB1,LAMC2,FHIT,CCNE2,LAMA3,FN1,NOS2,BIRC7
    Wnt signaling pathway WNT3A,SFRP1,PRKCBA,NLK2,FZD6,FZD8B,DAAM2,CXXC4,TP53,FBXW11
    Basal cell carcinoma WNT1,WNT11,GLI2,WNT5A,FZD10,PTCH1,GLI1,FZD3,SETD6,DVL1
    Proteoglycans in cancer WNT7A,HGF,Fasl,ARAF,PPP1CB,WNT9B,HPSE,PLCE1,ERBB4,NRAS
    Chronic myeloid leukemia ABL1,MAPK3,GAB2,RUNX1,IKBKG,MAP2K1,PIK3R2,BAD,NRAS,CTBP1
    Epstein-Barr virus infection PRKACA,CDK1,POLR3H,PSMC5,PSMC2,SND1,POLR2F,SHFM1,PIK3R3,CCNA2
    Glioma TGFA,PRKCB,AKT2,TP53,CAMK2B,PDGFRA,PRKCA,MAPK3,AKT1,MDM2

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protease binding FADD,Serpina1c,PEO1,ITGA3,TYSND1,ADRM1,INS2,PANX1,RYR1,DVL3
    metal ion binding BIRC5,ZSCAN20,CLCA5,ZNF615,PRDM15,ELAC1,PPEF2,PFKP,ZNF543,ZFP451
    double-stranded DNA binding CSDA,CGGBP1,HMGB3,XRCC6,TP73,SETMAR,HES2,RAD51L1,HMGB2,TRP63
    chromatin binding CTBP2,TOP1,RERE,NCAPD2,UBTFL,SIRT2,AAAS,EOMES,MPO,SLC30A9
    protein heterodimerization activity LTC4S,NKX2-5,TFAP2B,NAE1,PRPH,ODZ4,DMBX1,SMAD4,FLOT2,PPP1CBL
    protein kinase binding CCND2,IL12RB2,FBXO5,SHC4,MAP3K5,DBF4B,SYK,SREBF1,PIFO,HIF1A
    protein binding C11orf65,SNX12,RUNX3,HNRNPD,REST,SEC24A,POLL,CDKN1C,TUBA1A,MTOR
    ubiquitin protein ligase binding TP53,EGFR,RNF20,FZD6,FAF1,TRIOBP,TRAF1,TSG101,WASH,LC3
    receptor tyrosine kinase binding CPNE3,ANGPT1,PCNA,NRG1,DNAJA3,LRP4,SHC3,SHC4,GNB2L1,ANGPT2A

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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