Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Basal cell carcinoma SUFU,FZD8,WNT7A,FZD9,STK36,LEF1,WNT3A,AXIN1,TP53,WNT7B
    Chronic myeloid leukemia ABL1,IKBKG,NFKB1,CCND1,MAP2K1,AKT1,CTBP2,MECOM,CRK,BAD
    Measles Il2,CD28,IFNA12,STAT2,IFNA21,AKT2,TAB2,EIF2AK1,CD209B,TP53
    Non-small cell lung cancer BRAF,KRAS,RB1,BAD,PRKCG,HRAS,AKT1,EML4,PIK3R2,FHIT
    Pancreatic cancer NFKB1,MAPK10,MAPK1,VEGFA,RALGDS,STAT1,CASP9,TGFB2,TGFA,RELA
    Huntingtons disease ATP5H,ATP5A1,POLR2J,VDAC2,COX5B,DNAHC8,NDUFB5,DNAH11,COX7C,NDUFS3
    Melanoma ARAF,IGF1R,PIK3R2,FGF16,RB1,PIK3R1,FGF6,PIK3CD,FGF21,FGF2
    Glioma MAPK3,RB1,CALM4,IGF1,HRAS,PIK3CA,BRAF,PLCG2,SHC4,PDGFB
    Pathways in cancer ARNT2,IL-8,FH1,SKP2,RASSF5,GLI3,FGF8,GNG13,AXIN1,BRAF

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    p53 binding STK11,CHD8,ZFP346,PTTG1IP,TP63,SMARCA4,HTT,TRIAP1,SETD8,BRD4
    histone acetyltransferase binding PCNA,HIF1A,GLI3,CITED2,TRIM68,KAT2B,TAF7L,CEBPB,MTF1,EID1
    protease binding SERPINA1A,CNTNAP2,ADAMTSL4,Cstb,PINK1,THAP5,CHL1,SEMG2,SERPINA1,CSTA
    sequence-specific DNA binding POU2F3,GLI2A,FOXJ2,NR2F5,PPARGC1A,HOXB8B,HOXC8A,FOXG1A,HOXB4,NR2F6B
    ubiquitin protein ligase binding GPI,FZD6,UBE2J2,FAF1,FBXW7,PA2G4,PRKAR1A,NGFR,CDKN1A,MC4R
    copper ion binding ATP7A,MT1,PARK7,PRNP,COMMD1,CCS,PRNPA,HEPHL1A,LOXL1,POLR1B
    protein kinase binding GRIN2A,NBEA,HIF1A,MSN,ATF2,VRK1,FBXO5,FGFR1OP,PLK1,CDC25B
    double-stranded DNA binding TP73,TP63,RAD51L3,AKAP8,HMGB1,NTHL1,IFI203,SAFB,XRCC2,RBMS1
    protein self-association AGA,ADAM8,CBR2,CTSC,SVIP,TNFAIP3,ABCD3,L1CAM,PCSK9,CCDC88C

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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