Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Non-small cell lung cancer AKT1,PIK3R5,RARB,TP53,AKT2,BAD,EML4,PRKCA,HRAS,FHIT
    Neurotrophin signaling pathway SHC2,MAPK13,CAMK2G,RPS6KA3,RPS6KA5,NGF,PRDM4,RPS6KA6,BCL2,KIDINS220
    Colorectal cancer PIK3R5,APPL1,MAPK1,RALGDS,BRAF,Casp3,TP53,BAX,MAP2K1,TCF7
    Prostate Cancer INS2,CCND1,GSK3B,ACTL6B,TGFA,INS,Pdgfa&Pdgfb,NFKBIA,MTOR,ERBB2
    Endometrial cancer MAP2K2,BRAF,AXIN2,LEF1,RAF1,MAP2K1,ARAF,PIK3R2,MAPK1,HRAS
    Bladder cancer EGF,E2F1,DAPK2,MMP9,MAP2K1,MAP2K2,VEGFA,ERBB2,THBS1,MMP1A
    Cell cycle RCC2,TUBG1,FOXM1,HIST3H2BB,SDCCAG8,SGOL2,MND1,CEP57,STAG1,H3F3B.1
    Huntingtons disease CREB3L2,DNAI1,BAX,DNAL4,POLR2B,TAF4B,SDHD,NDUFC2,EP300,SOD2
    Thyroid cancer RET,KRAS,CDH1,BRAF,TP53,TCF7L2,RXRG,PPARG,MAP2K1,TFG

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    transcription regulatory region DNA binding NKX3-1,MTERFD1,RFX3,CDK5RAP2,KLF1,IKZF1,SALL3B,ZFHX3,BRCA1,ZFP161
    histone deacetylase regulator activity NCOR1,MAPK8,TP53
    DNA binding HOXD11A,KDM5BA,HIST1H1T,ZFP410,VDR,TCF25,GATA3,MCM6L,UHRF2,IRX7
    transcription factor activity, sequence-specific DNA binding KLF11,SALL3,CTBP1,NR1D2A,FOXD3,SIM1,ALX1,HOXC6A,MTA3,ZNF436
    metal ion binding ZNF571,TNFSF10,VAV3B,SORBS2,SUZ12B,NEURL1AB,KAT8,RNF180,KLF16,NTNG1
    protein phosphatase 2A binding SPHK1,BCL2,MASTL,CPD,GRIN3A,SMG7,EIF4EBP1,ENSAA,MAPT,FOXO1
    sequence-specific DNA binding IRX2A,HNF4G,FOXL1,SATB1A,SMAD3,HOXA11A,GRHL2A,ENG1A,MSXB,HES1
    protein binding TBC1D17,ZNF227,HADHB,MXI1,ATXN7,ABLIM1,ARID3B,NSF,F2RL1,STK39
    p53 binding DAXX,ZNF385D,CDKN2A,ZFP385C,PTTG1IP,BANP,SMARCA4,ANKRD1,EHMT2,CHD8

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All Trp53 Products

    Required fields are marked with *

    My Review for All Trp53 Products

    Required fields are marked with *