Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Transcriptional misregulation in cancer MLL1,TMPRSS2,ATM,RXRG,CLSTN2,ETV1,PFTK1,HOXA11,SIN3A,ETV4
    Chronic myeloid leukemia SHC1,PIK3CB,CCND1,SMAD4,BRAF,CDK6,PTPN11,RUNX1,TGFB1,AKT1
    p signaling pathway GADD45B,STEAP3,BID,CCND1,PERP,Casp3,GADD45AA,CCNG2,TP53AIP1,MDM4
    Small cell lung cancer CCND1,PIK3R2,NFKBIA,LAMB3,BIRC8,PIK3CD,TP53,PIK3CA,LAMC2,ITGA6
    Proteoglycans in cancer CTTN,WNT8A,ITGB5,WNT8B,VEGFA,CBLB,CAV1,FZD2,PLCG1,SDC1
    Pancreatic cancer MAPK8,TGFB3,MAPK3,IKBKG,AKT1,SMAD4,MAPK10,KRAS,VEGFA,PIK3CB
    MicroRNAs in cancer APC,DNMT3A,HNRNPK,ITGA5,CD44,PRKCG,PRKCB,DNMT1,SIRT1,MCL1
    Thyroid cancer TCF7,RXRB,LEF1,CCND1,TPR,PAX8,TFG,MAP2K2,BRAF,RXRG
    Apoptosis DIABLOB,PPP3R2,PPP3CA,TNFRSF10B,CASP3A,IRF2,SPNA2,APAF1,JUN,DBNLA

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    copper ion binding RNF7,APOA4,CP,S100A13,SOD3A,HAMP,AOC2,ADNP,CCC2,LOXL3B
    protein self-association SHANK3,DYRK1A,ZSWIM2,S100A7A,PROSAPIP1,PABPN1,BCL10,CCL5,EPB49,DVL2
    protein phosphatase 2A binding EIF4EBP1,RPS6KB1,ARPP19,ANKLE2,STRN4,CPD,SMG5,MASTL,ENSA,GRIN3A
    enzyme binding ZFHX3,IQCB1,PPP1R3D,TGFB1,MDM2,NKX2-1,PCCA,HIF1A,NLRP1,UBE2L3
    chromatin binding BAHD1,RCC1,COQ7,BCL6,TFAM,CAPNS2,CCDC111,NONO,RNF2,ESR1
    core promoter sequence-specific DNA binding CRY1,SP1,KLF10,SOX9,NRF1,C1orf51,ZFP750,ZFP932,MTA1,ZNF750
    protein N-terminus binding MYO7A,TGFB1,KCNB1,ERCC3,TSC1,PDCD10,CHMP6,YWHAQ,NCOA3,MNAT1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding TTC6,POU2F2,ATOH1,SOX11,E2F4,SMAD2,MITF,HOXC11,KCNA3,NRL
    double-stranded DNA binding MTERFD1,TARDBP,CGGBP1,TDP1,TP63,DDX11,TDG,KLF6,NTHL1,FEN1

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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