Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bladder cancer MMP9,CDH1,RAF1,CXCL8,FGFR3,CDKN2A,E2F3,MYC,MMP1,RASSF1
    MicroRNAs in cancer HMGA2,CCNE2,EP300,ABCB1,DNMT1,SIRT1,BCL2,SERPINB5,PIK3R2,RASSF1
    Herpes simplex infection IFNA1,FADD,PVRL1B,TAP1,TLR3,IRF9,H2-AA,NFKBIB,OAS1B,NFKBIAA
    Central carbon metabolism in cancer HKDC1,G6PD,HK1,MAPK1,FGFR1,PTEN,MAP2K2,SIRT3,MTOR,G6PDX
    Small cell lung cancer NFKB1,TRAF4,MAX,PIK3CA,PTEN,BIRC8,LAMB1,RXRG,BCL2,PIK3CG
    Transcriptional misregulation in cancer ETV6,FLT1,MAX,GOLPH3,ETV7,ARNT2,TLX1,BMI1,ELANE,HIST1H3I
    Huntingtons disease ATP5F1,SP1,NDUFA10,POLR2A,COX7A2,DNALC1,DNAI1,NDUFV1,COX7B,NDUFA6
    Hepatitis C Ifna11,TRADD,CXCL8,CLDN17,CLDN1,SOS1,HRAS,BRAF,PPP2R2A,CLDN3
    HTLV-I infection DVL3,RELA,EGR1,SLC25A4,FZD5,CREM,KRAS,MAPK8,EP300,WNT1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    histone deacetylase regulator activity TP53,MAPK8,NCOR1
    protein phosphatase binding HSF4,ERBB2,TRAF3,CDH5,PPP6R1,PPME1,RPA3,JUPA,VRK3,MAP3K5
    chromatin binding BEND6,NKX6-1,LRWD1,PRKCBP1L,NAP1L2,GATA2A,TP73,MBD1,RNF168,HMGB1
    protein C-terminus binding DYNLL1,CITED1,CDC37,ECM1,SREBF2,GRIP1,TAF13,MAP3K7,MAP2K1,TNNI3K
    identical protein binding NLRC4,BAX,PPPDE2,HAPLN2,HGF,APIP,RABAC1,SF1,SDK2,ENTPD2
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding HMGA2,FOSB,HIF1A,NFAT5,SOX12,ONECUT2,MESP1,TP53,NRL,DDIT3
    RNA polymerase II transcription factor binding ZFPM2A,KLF4,TP53,GATA2B,ANKRD1,MEF2A,ZGLP1,GFI1B,SFPI1,NFATC1
    RNA polymerase II regulatory region sequence-specific DNA binding ATF5,FERD3L,ESRRG,NR1I2,CREBBP,DMBX1,ZMYND11,ZNF79,PLAGL1,BARX1
    protein binding MRPL13,ACE2,REG3A,SYTL1,ZNF3,H1F0,CLK2,FBXW8,PLEKHF2,RPL23A

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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