Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    p signaling pathway RCHY1,LRDD,CCND2,ATM,CASP3A,PIDD1,BAX,TP53I3,SHISA5,PTEN
    Proteoglycans in cancer ARHGEF1,CAV2,RPS6KB2,MAPK12,VEGFA,CAV3,WNT8A,CBLC,TWIST2,ROCK2
    Apoptosis APAF1,BADB,CFLARA,SPNA2,PPP3CB,ATM,DIABLO,TICAM1,BNIP3L,DSG1
    Glioma NRAS,PDGFRA,SOS1,CALML3,AKT1,IGF1R,PDGFB,PTEN,PIK3CA,RAF1
    Neurotrophin signaling pathway PTPN11,NFKBIB,PIK3R3,CAMK2G,MAPK12,PIK3R2,AKT2,RAPGEF1,MAPK11,RPS6KA2
    Pathways in cancer DAPK2,MET,FGF6,FGF11,RARA,FGF5,CCNA1,GNB3,PLCG2,NTRK1
    Huntingtons disease NDUFA6,SDHD,IFT57,POLR2L,POLR2H,DNALI1,PPIF,COX8C,DNAH11,TP53
    Measles STAT1,CD3G,IRAK1,MAVS,IFNA5,NFKB1,IFNGR1,IL6,CCND2,OAS3
    Amyotrophic lateral sclerosis (ALS) PRPH,TOMM40,MAP2K6,MAPK11,SLC1A2,BAD,GRIN2C,CASP1,RAC1,TOMM40L

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding EBF4,TFAP2B,OTX1,STK16,TBX20,STAT3,PITX2,PHOX2B,FOXJ1,MEOX1
    core promoter sequence-specific DNA binding SOX9,TOP1,PRMT5,MYOCD,GATA3,C1orf51,ESR2,REST,ATF4,SOHLH2
    p53 binding ZFP385C,ZNF385C,TP53BP1,MAPKAPK5,TP53RK,ZNF385D,TP63,EP300,KDM1A,RCHY1
    protein C-terminus binding MKI67,TNNI3K,NCF2,SHANK2,PROP1,PIAS3,MID1IP1,VGLL1,ATP2A2,KPNA3
    protein kinase binding NEK9,YWHAZ,MAP3K12,RPS3,KIF14,TUBB3,CDK5RAP2,MAVS,PFKFB2,NPR1
    ubiquitin protein ligase binding TANK,TPI1,DNAJA1,UBXN1,PTPN22,NEDD8,UBE2V2,GABARAPL2,MAP1LC3C,CUL4B
    ATP binding UBE2D4,DCKL1B,CCT2,GRK1,ATP5A1,IPPK,PTK7A,ATP4A,TRAP1,STK40
    DNA binding HDGFRP2,HMGB2A,C14orf43,ZFP36L1,ZNF444,ZNF286A,ASH2L,TERT,MYNN,ZFP768
    protein self-association ZNF496,TMEM43,AGTR1A,TTN,CCDC88C,TMEM190,PROSAPIP1,CCL5,ABCD3,S100A7A

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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