Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amyotrophic lateral sclerosis (ALS) PPP3R1,TOMM40L,DAXX,ALS2,RAC1,GRIN2B,BCL2,CASP12,MAPK12,GRIN2A
    Neurotrophin signaling pathway NTF4,PSEN1,ZNF274,PSEN2,RAP1B,YWHAE,RIPK2,MAPK13,ARHGDIA,MAP2K7
    Measles IFNA2,IL2RA,TACR1,IL4,RAB9B,SLAMF1,STAT5A,HSPA8,IFNA10,FCGR2B
    MicroRNAs in cancer SHC1,SOX4,KIF23,SLC45A3,ABCB1,ERBB2,NOTCH4,TPM1,GLS2,ZEB1
    PIK-Akt signaling pathway GYS2,ITGB8,GNG8,ITGA2,ITGAV,GNB1,ITGB4,PDGFRB,SOS1,Fasl
    Hepatitis B TLR2,PTK2B,CXCL8,SMAD4,MYD88,FASLG,AKT2,IKBKE,IFNA12,ATF4
    Sphingolipid signaling pathway MAPK9,PPP2R3C,RAC3,PLCB3,PPP2R2D,MAPK1,PLCB4,SPHK2,RHOA,LOC100328615
    Hepatitis C TYK2,CLDN7,RXRA,DDX58,CLDN8,IKBKG,IFNB1,PPP2R1A,STAT3,Ifna11
    Herpes simplex infection IFNA17,EEF1DB,TTC6,PTPN11B,SKP1,CRFB2,IL12A,Ccl12,HLA-DQA1,IRF7

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    p53 binding TAF3,TP53BP1,TAF1,RFFL,KDM1A,ZFP385C,EHMT2,TRIM29,MAPKAPK5,AXIN1
    protease binding CNTNAP2,STIM1,ALPI,TRIP4,INSL3,ECM1,SERPINA1D,ADAMTS4,TIMP3,SERPINB9
    transcription factor activity, sequence-specific DNA binding JUNBB,HIST1H2AH,ETS2,TCF3A,IKZF2,MTA2,GBX2,FOXJ1,TCF7,MESP1
    receptor tyrosine kinase binding SHC3,ZFP259,FNTA,PTPN2,FIZ1,SHC4,ANGPT2A,ANGPT2,PITPNM3,TOB1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding BARX1,PLAGL1,GATA1,BARX2,PPARG,ZGLP1,MAFB,ARID3A,CSRNP2,PAX9
    protein N-terminus binding ERCC6,CSNK2A1,TGFB1,SCT,HESX1,KCNIP1,NCOR2,BIRC2,SUV39H1,KCNIP2
    core promoter sequence-specific DNA binding NR1D1,CHD2,MYOCD,MTA1,ZFP932,GATA3,MLL1,C1orf51,SOX1,REST
    histone deacetylase regulator activity NCOR1,MAPK8,TP53
    transcription factor binding TBL1X,IFI203,PAX6,HDAC9,HES3,HYAL1,ESRRB,GATA6,SOX10,MYC

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All Trp53 Products

    Required fields are marked with *

    My Review for All Trp53 Products

    Required fields are marked with *