Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glioma PRKCG,CALM2,HRAS,PDGFRA,Pdgfa&Pdgfb,AKT1,PIK3R3,CALM3,PDGFA,CALM4
    Pancreatic cancer BAD,RALBP1,MAPK3,MAPK8,CCND1,TGFB3,AKT2,MAPK9,RB1,ERBB2
    Neurotrophin signaling pathway RPS6KA5,NFKBIE,PTPN11,TRAF6,FASLG,NRAS,RAP1A,CAMK2A,GAB1,MAP2K5
    Viral carcinogenesis YWHAB,LYN,MAPK3,ACTN4,TRAF1,PXN,KAT2A,CREB3L1,CDC42,STAT5A
    PIK-Akt signaling pathway PDGFA,IFNA4,FGF8,FGF12,IRS1,IFNA2,INS1,EPOR,PIK3R3,PIK3CD
    Central carbon metabolism in cancer PIK3R2,PKM,FLT3,PTEN,FGFR3,HRAS,HK2,RAF1,PGAM1,SLC7A5
    Prostate Cancer PDGFC,EP300,HSP90AB1,SMARCA4,PIK3CB,GSTP1,HSP90AA1,INS,Ar,PIK3CG
    Measles IFNA14,EIF2AK1,GSK3B,STAT3,IFNA2,MX1,TBK1,STAT5A,PIK3R3,TNFRSF10B
    Basal cell carcinoma WNT9A,WNT16,LEF1,GLI2,HHIP,BMP4,GSK3B,PTCH1,FZD5,SUFU

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    transcription regulatory region DNA binding ATMIN,HIVEP2A,MTERFD3,KDM1A,RBBP5,ATF4,PAX8,KLF1,AIRE,TA
    double-stranded DNA binding TRP63,PYDC3,HMGB2,MTERFD1,PNKP,TEF,RAD51L3,HNRNPDL,CRY1,RAD51C
    damaged DNA binding DCLRE1C,UNG,RAD23B,XRCC6,RAD52,TP53,TRP63,OGG1,EP300,FEN1
    DNA binding HIST1H111R,TIGD5,LEF1,HOXC6B,FOXM1,ILF3,ZNF789,HMGB1A,TGIF2LY,ZNF311
    protein heterodimerization activity SCGB2A1,PPP3CB,BNIP3L,HIST1H4H,NKX2-5,VEGFB,TLR1,UGT1A9,F11R.1,SOX6
    transcription factor activity, sequence-specific DNA binding ZNF577,SMAD3A,ZNF383,MSRB2,KDM5A,ZNF480,ZFP260,ZNF567,ATF5,DLX4
    transcription cofactor binding FOXO3,KLF4,CHD6
    histone acetyltransferase binding ETS1,SP1,EGR1,SIRT2,TRIP4,MYOCD,EPAS1,PCNA,PAX6,CITED2
    core promoter sequence-specific DNA binding SOHLH2,THRAP3,ESR2,NR1D2,ESR1,SOX4,NRIP1,MLL1,ZNF750,TP53

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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