Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid signaling pathway FCER1A,ROCK1,RELA,NRAS,AKT1,PPP2R3C,MAPK8,PLD1,PPP2R5D,S1PR2
    Endometrial cancer MAPK3,TP53,MAP2K1,CDH1,GRB2,APC,ILK,SOS1,LEF1,PIK3CA
    Central carbon metabolism in cancer HK2,PIK3R5,PIK3CD,FLT3,SIRT3,FGFR2,SIRT6,HKDC1,G6PD,SLC16A3
    Viral carcinogenesis MAPK3,HLA-G,YWHAG,HIST1H2BB,HNRNPK,YWHAH,C3,HRAS,BAX,HLA-A
    Small cell lung cancer IKBKB,ITGA6,RXRB,CCNE2,TRAF2,APAF1,IKBKG,BIRC8,CKS2,XIAP
    Non-small cell lung cancer PIK3R2,PIK3R5,BAD,BRAF,FHIT,FOXO3,PRKCB,TGFA,AKT1,SOS1
    Thyroid hormone signaling pathway NCOR1,MED30,MED13,SLCO1C1,NRAS,ATP1B3,RAF1,TP53,PLCB2,ATP1B1
    Thyroid cancer CDH1,NCOA4,KRAS,PAX8,TPM3,LEF1,RXRG,NTRK1,RXRB,NRAS
    Colorectal cancer MAPK8,SMAD4,ARAF,CYCS,PIK3CG,BAX,FOS,MAPK9,MSH6,RAC2

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding RORCA,CYP21A1,PHF23A,ZBTB2B,LFNG,KDM7AB,ARMC1,CYP2C55,ZNF174,PLAGL1
    transcription factor activity, sequence-specific DNA binding ZFP39,KLF1,NR6A1B,TBX19,PAX6,FLI1B,ZFP260,FOSL1,GTF3A,SHOX
    protein phosphatase binding VCP,VRK3,JUP,JAK3,LCK,MVP,MAP2K7,SNX3,PPME1,PPP6R3
    protein binding AGBL1,ISL1,IL12B,ACMSD,PIAS2,TP53BP1,HMGN2,AGO1,NDE1,GPATCH8
    core promoter sequence-specific DNA binding SP1,PDX1,SOX4,MTA1,H2AFY,TOP1,ATF4,NR1D2,NRIP1,PRMT5
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding TP73,ELK1,TTC6,TFAP2C,MEOX2,NEUROD6,CEBPZ,ARNT2,NR2E1,NKX2-8
    RNA polymerase II transcription factor activity, sequence-specific DNA binding SP3A,FOXM1,TFDP1,FOXD4,ZNF576,EF1,JUNBA,FOXI3B,PLAGX,ETS1
    histone acetyltransferase binding GLI3,TAF7L,EPAS1,TP53,TAF7,CREB1,NR4A3,ETS1,PAX6,FOXP3
    copper ion binding LOXL3,DCT,TYR,COMMD1,CCS,APOA4,CP,LOXL2A,SOD1,ATOX1

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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