Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hepatitis C HRAS,TP53,TRADD,PPP2R1A,CLDN11,SOCS3,CXCL8,MAPK13,CLDN7,IFNA17
    PIK-Akt signaling pathway GNB3,SGK3,YWHAG,FGF5,PTK2,GNG8,GYS2,IFNA16,AKT2,GNG3
    Colorectal cancer TCF7,RAF1,SMAD4,MAPK10,RAC2,TGFBR1,PIK3R1,AXIN2,APC2,CASP9
    MAPK signaling pathway RAC3A,ARRB1,HSPA8,HSC70,PPM1AB,RAF1,CACNB2,GADD45AB,KRAS,CACNG1A
    Measles CD3E,STAT2,IFNA8,TLR9,IKBKE,HSPA1L,SLAMF1,IL2RG,IFNA21,PIK3R3
    Chronic myeloid leukemia PTPN11,CBL,PIK3CG,NFKBIA,SHC4,PIK3R2,CBLB,CRK,MECOM,CDK6
    HTLV-I infection WNT8A,NFATC3,HLA-B,CREM,EP300,SLC25A6,MAP2K4,BUB3,MAP3K1,MAP3K14
    Endometrial cancer GSK3B,RAF1,CTNNA2,ILK,PDPK1,MAPK3,PIK3CD,APC,PIK3R5,GRB2
    Pancreatic cancer MAPK8,IKBKB,PLD1,PIK3R5,MAPK10,STAT3,RB1,MAPK9,MAPK3,PIK3CD

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein phosphatase binding CDKN1B,CDH2,CTNNB1,IRS2,JUP,ERBB2,ITGA1,JAK1,TRAF2,EIF2AK3
    MDM2/MDM4 family protein binding CDKN2A,CDK5RAP3,CAV1,RFWD3,PPARA,PSME3
    protein phosphatase 2A binding PTPN1,CTTNBP2NL,CPD,PPME1,STRN4,SMG7,ANKLE2,BCL2,MAPT,EIF4EBP1
    receptor tyrosine kinase binding FLT3LG,SOCS5,FIZ1,PITPNM3,NRG1,GNB2L1,ANGPT2A,MYOC,SHC3,PTPN11
    protein C-terminus binding AXIN1,PROP1,DLG3,SNF8,SP1,CAV3,ID1,YAP1,TOP2B,OPRL1
    copper ion binding SNCA,MT1,SNAI3,DBH,SCO1,TYRP1B,PARK7,LOXL2,S100A5,ATOX1
    transcription factor binding MED6,PPID,SOST,AHR,IRF4,FOXO1,APBB3,RARA,ZEB1,KCTD1
    double-stranded DNA binding XRCC2,TRP63,TEF,DDX11,TDP1,TDG,DMC1,KLF6,HES2,RAD51L1
    ATP binding MYO1C,EPHA1,MKI67,VMHCL,KDRL,FYNB,PKZ,PIKFYVE,ABCA8,Adcy4

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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