Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Central carbon metabolism in cancer AKT2,PFKL,MAPK3,HK3,PGAM1,FGFR3,GLS2,SLC7A5,HKDC1,KIT
    Huntingtons disease ATP5H,VDAC3,REST,CREB3L2,BAX,COX7C,UQCRC2,DNAH14,CASP9,HTT
    Epstein-Barr virus infection PSMC5,YWHAZ,HLA-DRA,RELA,POLR2J,POLR3H,EIF2AK3,YWHAH,HLA-DRB4,SND1
    Herpes simplex infection SFRS9,MYD88,RNASEL,TBPL2,TBP,TRAF6,BF1,IFNA1,CYCSB,NFKB1
    Pancreatic cancer IKBKB,RAC3,TGFA,TGFBR2,PIK3R5,AKT1,MAPK3,RAF1,SMAD4,RAD51
    Thyroid cancer BRAF,RXRA,NCOA4,TPM3,CCND1,RET,TFG,TP53,TPR,CDH1
    Apoptosis PTBP3,HIST1H1C,CAPN2A,CTNNB2,TICAM1,CASP2,BIRC8,CASP9,PPP3CCB,CAPN1
    HTLV-I infection VDAC1,LTBR,PIK3CD,PDGFRB,SPI1,TERT,ZFP36,HLA-DPA1,IL1R1,TNFRSF1A
    Colorectal cancer AXIN1,SMAD2,PIK3R1,GSK3B,SMAD4,TCF7,TP53,MLH1,KRAS,MAP2K1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    core promoter sequence-specific DNA binding NRF1,TOP1,PROX1,ZFP932,SOHLH2,ESR1,SOX4,ZFP750,MYOCD,NR1D1
    ubiquitin protein ligase binding IKBKG,MAGEA2,CD40,H2-AB1,BRCA1,GABARAP,UBE2A,CDC34B,HSPA5,C10orf46
    RNA polymerase II transcription factor binding ZFPM2,PITX2,CREBBP,MTA2,GATA2A,TAL1,KDM1A,SFPI1,ZFPM1,XBP1
    protein N-terminus binding EXOC5,BIRC2,KCNIP1,STXBP1,SMARCC1,GTF2H3,ALOX5AP,ACOX1,CSNK2A2,EIF5A
    p53 binding HTT,PTTG1IP,SMARCB1,TRP63,ANKRD1,TP53RK,DAXX,TRIM29,USP10,NTRK3
    protein kinase binding LATS1,IFNAR2,PKD1,AKAP1,NGFRAP1,YWHAZ,CEP68,RPTOR,RHEB,TBC1D14
    damaged DNA binding HMGB2,POLH,NEIL2,TP53BP1,XRCC5,BRCA1,PCNA,APEX1,RAD23B,OGG1
    transcription cofactor binding CHD6,KLF4,FOXO3
    receptor tyrosine kinase binding NRG1,TOB1,ZFP259,Flt3l,NCK1,LRP4,PITPNM3,NRG3,TP53,ZNF259

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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