Trp53

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Trp53

Official Full Name transformation related protein 53
Synonyms bbl; bfy; bhy; p44; p53; Tp53
    • Species :
    • Mouse
    • Source :
    • E.coli
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse TRP53-17432M Recombinant Mouse TRP53 Protein Mammalian Cell His
    Mouse Trp53-5632M Recombinant Mouse Trp53 protein, His-tagged E.coli His
    Mouse Trp53-6671M Recombinant Mouse Trp53 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Kit-0642 p53 Translocation Assay Kit (Cell-Based) N/A
    Kit-2107 p53 Transcription Factor Activity Assay Kit N/A

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPK7; FGF20B; CACNA2D1; EGFRA; PPP5C; TGFBR2; RAC3B; RAC1; PPP3CA; NFATC1
    Sphingolipid signaling pathway LASS2; PIK3R5; RELA; RAC2; S1PR5; RHOA; MS4A2; BDKRB2; GAB2; ROCK2
    Cell cycle KAT5; ANAPC11; CSNK2B; FOXM1; HAUS2; CCNB1; CCNB3; HIST4H4; DCTN3; SMC1A
    p signaling pathway COP1; PERP; CD82B; SESN1; TP53I3; IGF1; BAXA; CDK1; CYCSB; BID
    PIK-Akt signaling pathway NRAS; FASLG; RPS6KB2; PDGFC; FGF20; YWHAG; IL6; PKN1; PIK3CA; PRKAA2
    Apoptosis ENDOG; PRKAR1AB; AKT2L; HMGB2; XIAP; CTNNB2; ADD1; DIABLOB; TICAM1; OCLN
    Wnt signaling pathway FZD6; EP300; NFATC3; TRP53; CAMK2B1; SMAD4; DAAM1; FZD1; PRICKLE1A; PRKCB
    Neurotrophin signaling pathway ZFP110; NTRK3; RPS6KA2; PIK3R5; MAPK10; IRAK2; NRAS; NFKBIA; BRAF; MAPKAPK2
    Thyroid hormone signaling pathway SLC2A1; MED4; PIK3CA; NOTCH2; PLCZ1; CASP9; ATP1B2; HIF1A; FXYD2; PDPK1
    Amyotrophic lateral sclerosis (ALS) MAPK14; PPP3CB; TOMM40L; NEFM; TRP53; TNFRSF1B; Casp3; GRIN2C; DERL1; TNF
    Huntingtons disease COX8C; PPARG; HIP1; POLR2C; NDUFA13; CASP9; TFAM; UQCRQ; DNAL4; DNAH6
    Hepatitis C IKBKG; SOCS3; MAPK9; PPP2R2A; LDLR; CLDN23; CLDN7; OCLN; EIF3E; Ifna11
    Hepatitis B IFNA12; MAPK10; BIRC5; STAT3; STAT1; IFNA1; IFNA5; NFATC4; PIK3R1; CREB3L1
    Measles SLAMF1; IFNGR1; RELA; IFNA7; IFNG; IFNA14; CD209C; OAS1B; IFNAR1; PIK3CB
    HTLV-I infection KAT2A; RAN; IKBKB; DVL3; TNF; ATF4; MYBL2; TGFBR2; HLA-DQA1; IL2RA
    Herpes simplex infection IL1B; TAF6L; Hc; PPP1CC; CLOCKA; IL15; IFNA2; EP300; HCFC1B; CD74
    Epstein-Barr virus infection MAP3K14; POLR3GL; POLR2K; HLA-DPB1; PIK3CG; CSNK2A2; CD44; TBP; CCNA1; YWHAZ
    Pathways in cancer MMP1; NFKBIA; RXRG; GNG11; FZD7; AHA-1; GLI1; IGF1; LAMA4; NRAS
    Transcriptional misregulation in cancer RUNX1; PML; Bcl2a1b; ITGB7; PRCC; ERG; ETV1; DEFA3; MAF; SLC45A3
    Viral carcinogenesis LYN; PIK3R1; UBE3A; SP100; TRAF1; HDAC1; RHOA; HDAC7; PXN; PIK3R5
    Proteoglycans in cancer WNT8B; SDC4; WNT2B; CAMK2B; PLAU; FGF2; FZD9; FZD8; WNT5B; PIK3CB
    MicroRNAs in cancer MAPK1; CCND1; RASSF1; IRS2; Casp3; CCNG1; BMI1; ABCB1; FSCN1; FZD3
    Colorectal cancer SMAD4; MLH1; Casp3; RAC3; TCF7; TRP53; TP53; MAPK9; MSH2; DCC
    Pancreatic cancer PIK3R3; TGFB1; MAPK3; MAPK1; RAD51; PIK3CD; TGFA; STAT1; PIK3R5; BRCA2
    Endometrial cancer PIK3R1; MAP2K1; APC2; MAPK3; SOS1; BAD; AKT1; PIK3R2; PIK3R5; NRAS
    Glioma MTOR; CAMK2G; CALM3; PDGFA; PDGFRB; CALM2; IGF1; MAPK3; PIK3R5; SHC2
    Prostate cancer SRD5A2; FGFR2; BCL2; AKT1; CREB3L2; PIK3CG; SPRY1; MTOR; PDPK1; GRB2
    Thyroid cancer NCOA4; MAPK1; CDH1; MAP2K2; NRAS; NTRK1; KRAS; RET; PAX8; TFG
    Basal cell carcinoma WNT3A; WNT2; WNT1; TCF7; SETD6; WNT5A; DVL1; WNT4; FZD1; WNT8A
    Melanoma FGF17; FGF12; HRAS; FGF21; PIK3R1; IGF1R; Pdgfa&Pdgfb; PDGFRB; PDGFB; PDGFRA
    Bladder cancer THBS1; MAP2K1; RASSF1; RB1; MAPK1; TP53; ARAF; RPS6KA5; BRAF; HBEGF
    Chronic myeloid leukemia TGFB1; STAT5A; CRKL; PIK3R3; RAF1; SHC3; BRAF; NFKB1; ARAF; TGFBR1
    Small cell lung cancer ITGA2; LAMB2; NOS2; RXRG; ITGAV; BIRC2; LAMA5; PIK3CA; PIK3CD; PIAS2
    Non-small cell lung cancer PIK3CG; BAD; PLCG1; FHIT; CCND1; PRKCG; SOS1; ARAF; NRAS; PDPK1
    Central carbon metabolism in cancer PDHB; TRP53; GLS; PIK3CA; FGFR2; G6PD; HRAS; PKM2; MAP2K2; FLT3

    Trp53 has several biochemical functions, for example, ATP binding, DNA binding, MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding GRK7; DDX46; SCYL2; AAK1; MYO6A; HELZ2; KIF3CB; PRKD3; PKN2; ATP2B2
    DNA binding ZBTB37; HIST1H3D; HES4; POGZ; ZNF581; EP400; KDM2AA; ZNF484; NFE2L2A; THAP3
    MDM2/MDM4 family protein binding PPARA; TRP53; RFWD3; PSME3; CDK5RAP3; CAV1; CDKN2A
    RNA polymerase II core promoter sequence-specific DNA binding NLRC5; RREB1; GATA1; STAT6; MTF1; TAL1; NR4A2; H3F3B; ZNF277; HOXB3
    RNA polymerase II regulatory region sequence-specific DNA binding PLAGL1; BARHL2; TAL1; RELB; ATF5; ZNF711; ZIK1; TFAP2C; TRP53; ZNF792
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FLI1B; ZNF488; ETV4; TFAP2E; FOXD4; ZMYM5; BMPR1A; EPAS1; ZNF215; ELF2A
    RNA polymerase II transcription factor binding MEF2A; GATA5; TRPS1; ZFPM2; SPI1; GFI1B; TAL1; ZGLP1; MKX; ID4
    chaperone binding HSPD1; SOD1; ERP29; TIMM9; DNLZ; VWF; SERPINA7; INS1; TSACC; GNB5
    chromatin binding JUB; RCC1; ERG; KDM6B; MLL1; UBTF; PYGO2; TOX2; EZH2; TOX
    copper ion binding HAMP; SLC11A2; LOXL3; PAM; ATOX1; CP; SERPINB1A; COX17; S100A5; AOC3
    core promoter sequence-specific DNA binding MLL1; NRF1; NFYA; NRIP1; TP53; NR1D1; PDX1; SOX1; ESR2; CHD2
    damaged DNA binding CREBBP; ERCC1; TP53; POLH; APEX1; APTX; RAD18; NEIL2; TP73; RPA3
    double-stranded DNA binding FBXO18; MEN1; DDX11; MRE11A; RAD51B; HMGB3; MCM10; HLF; KIN; RAD51C
    enzyme binding CNTNAP2; KDM1A; MSH3; FAM84B; SIRT3; HDAC1; LGALS9; JUND; H2AFX; PTPLAD2
    histone acetyltransferase binding TRIM68; FOXP3; GLI3; TRP53; MTF1; PAX6; ETS1; TAF7; EID1; NR4A3
    histone deacetylase regulator activity TRP53; TP53; NCOR1; MAPK8
    identical protein binding CCDC91; APP; SIAH1; CEACAM16; VPS4B; TPD52L1; PTPRG; GDF5; CHEK2; TLE1
    metal ion binding ZDHHC22; LMAN2; DGKQ; ZC4H2; HIC2; ADAM25; LIG4; AIFM4; SMYD2B; HIC1
    p53 binding HSPD1; TAF3; TP53RK; TAF1; PSME3; MSX1; BCL2L12; KDM1A; EHMT1; BANP
    protease binding CD28; SERPINF2; INSL3; HSPD1; ADAMTS4; A2M; TIMP1; PEO1; DVL3; ITGB1
    protein C-terminus binding LCK; ERCC3; VPS36; VGLL3; SAE1; ERCC4; TERF2; MID1IP1; FIGN; MLLT4
    protein N-terminus binding STXBP1; MNAT1; SUV39H1; SMARCA4; NPAT; SDCBP; MAU2; SCFD1; MORF4L1; TBL1XR1
    protein binding CDK5R2; ADAMTSL5; JRK; CTNNB1; PRH1; SPEG; CCL4; FAM19A4; SDCBP; BTN3A1
    protein heterodimerization activity CXorf15; H2-AA; HIST1H2AG; HIST1H3G; GCLC; H2AFY; HIST1H2BB; DDX1; MYF6; VAPB
    protein kinase binding CAV1; B4GALT1; CCNL1B; ACTA2; MAPK4; FER; PARK2; DAXX; CD8A; PFKFB2
    protein phosphatase 2A binding MAPT; EIF4EBP1; ENSA; AKT1; FOXO1; MASTL; BCL2; IGBP1; STRN; SMG7
    protein phosphatase binding DRD1; LCK; DLG4; KCNN4; SKAP1; JAK1; PPP1R3C; GNB2L1; SNX3; CDH5
    protein self-association SYP; ACHE; DVL2; RYR2; CBR2; MALT1; TNFAIP3; CCDC88C; ACVR2A; DYRK1A
    receptor tyrosine kinase binding LRP4; ARHGEF16; DOCK4; ELMO2; FIZ1; GNB2L1; ZNF259; ANGPT1; SQSTM1; PTPN2
    sequence-specific DNA binding DLX5A; IRX5B; FOXR2; EDF1; HOXD13A; IKZF1; KDM6B; E2F5; TFCP2L1; ETV5A
    transcription cofactor binding FOXO3; TRP53; CHD6; KLF4
    transcription factor activity, sequence-specific DNA binding USF2; SIX1; HOXA5; GBX2; HOXB3; NFE2L1A; ZFHX3; NR1I3; HMG20A; FOXG1
    transcription factor binding ATG7; MYBBP1A; NAAA; TRIM6; MDFIC; RPS3; NFKBIA; HMGA1-RS1; PSMD4; ZBTB49
    transcription regulatory region DNA binding ATF4; ZFP335; ZNF174; ZNF649; KLF11; ZFP382; SMAD4; SALL2; ATF3; GATA3
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding PHOX2B; NRL; TFAM; TBX20; TLX1; SOX12; MYC; NEUROG3; ONECUT2; RBPJ
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding PLAGL1; STAT3; BARHL1B; NEUROD2; GLIS1; NKX2; ETV5; MAFG; ALX4; AIRE
    ubiquitin protein ligase binding RNF34; XBP1; PRKACA; CBS; SNCAIP; GPI; TUBB; UBE2NB; BID; TSG101

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40; atp; Mdm2

    Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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