Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MicroRNAs in cancer TRIM71,RDX,CDC25A,TNC,SIRT1,DICER1,HOXD10,ZFPM2,BRCA1,RECK
    Herpes simplex infection SRSF2,MYD88,ARNTL,CRFB2,HLA-DPB1,PER1,CD74A,C3,HNRPKL,POU2F3
    Hepatitis C TLR3,MAPK11,CLDN20,EIF2AK4,OAS2,AKT1,ARAF,CLDN6,TNF,EIF2AK2
    Neurotrophin signaling pathway MAP2K1,IRS1,RAPGEF1,PSEN1,CDC42,SH2B3,NFKBIE,SHC1,NTRK3,ZNF274
    Thyroid cancer NRAS,CCND1,TP53,TPR,RXRB,KRAS,MAPK3,TCF7L2,RXRA,PPARG
    Apoptosis DYNLL2,DFFA,TNFRSF10D,TNFRSF10B,PPP3R2,FADD,CASP9,PIK3R3A,IL1A,PPP3CC
    Amyotrophic lateral sclerosis (ALS) TOMM40,BCL2,PPP3R1,PPP3CB,BCL2L1,PPP3CA,MAPK13,TOMM40L,CAT,CCS
    Melanoma PIK3CA,MAPK1,FGF1,RAF1,FGF11,Fgf15,MAPK3,FGF10,KRAS,PDGFA
    Transcriptional misregulation in cancer PPARG,JMJD1C,PAX7,CD86,CCNA1,PER2,FLT3,TSPAN7,FCGR1A,RARA

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding HSPA2,STC2,TBP,HDHD2,DDC,STUB1,KALRN,CYP1A1,PTPLAD2,RCOR1
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding MAFB,MAFBA,ATF2,CREB3L3,ALX1,ETV5,DLX2,IRF2,MYOCD,BARX2
    RNA polymerase II core promoter sequence-specific DNA binding MITF,TP53,H2AFZ,NFIL3,SOX8,GATA1,ZFPM1,MTF1,GATA3,EP300
    sequence-specific DNA binding SALL1,IKZF3,LMX1A,ZNF831,SALL1A,ZSCAN10,HLX,NKX6.3,FOXQ1B,SALL2
    protein phosphatase binding JAK3,JAK1,ANAPC4,ITGA1,MVP,NEK2,LCK,VCP,VCAN,TRAF2
    protein binding OAS1B,NFYB,RAB5B,TAF9B,PI4KA,DPYSL5,SEMG2,DDX42,GNAS,STK38
    protein heterodimerization activity NEFL,NKX2-5,HIST1H3D,NFYBB,USF1,CEBPE,HIST1H2BD,UGT1A7,HIST1H2BM,CD3G
    ATP binding HIPK4,RUNX2,DALRD3,FAM20C,KIF18A,COASY,MLKL,NAGK,KATNA1,FER
    protease binding ADRM1,LRP1,SELL,BCL2,FN1,FURIN,PYCARD,TIMP3,NFRKB,TIMP2A

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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