Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pathways in cancer MLH1,CBLB,TGFB3,FZD8,EP300,GNAS,GNG5,PGF,RAF1,LAMC1
    Chronic myeloid leukemia MAPK3,ARAF,BRAF,PIK3CA,SHC1,GRB2,MAPK1,PIK3R2,CRK,CBLB
    MAPK signaling pathway RAP1AA,PRKACBA,FGF5,FGF14,FGF3,MAP3K5,MAPK8,FLNC,PRKCG,FGF20B
    Transcriptional misregulation in cancer LYL1,MLLT3,SSX2,ID2,BMI1,TSPAN7,TAF15,HIST1H3F,MYCN,BCL2A1
    Herpes simplex infection BF1,TAB2,BMA1,MHC2A,SRSF2A,PER3,IFNAR2,IFNA6,IFNA3,PPP1CAA
    Wnt signaling pathway WNT7AA,PPP3R1B,AXIN2,CCND3,PPP3CA,PRKACAA,NFATC4,FBXW11B,FZD5,FBXW11A
    Cell cycle OFD1,RAD9B,STAG2,SPC24,SMC2,VRK1,DCTN1A,CDK4,KAT5,CDKN1B
    Small cell lung cancer MAX,COL4A1,TRAF2,LAMC1,CYCS,BIRC3,NOS2,BCL2,PIK3R3,LAMA5
    Endometrial cancer PIK3R2,MAPK1,AKT2,ELK1,PTEN,PIK3R5,CCND1,BRAF,KRAS,PIK3CA

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding HES6,PHF21B,FOXK1,GATA1A,ATF4B2,STOX1,HMX1,EGR1,HOXD9,ALX1
    protein binding GAGE8,PAX2,SH3GL1,SLAMF6,RFC4,MOB1A,AP5Z1,B3GAT3,CABP5,CSGALNACT2
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GLIS1,PAX9,GATA2B,CEBPA,IKZF3,FOXF2,AIRE,HSF2,IRF2,GRHL3
    chaperone binding PIH1D3,DNAJA4,CXorf41,CTSC,SOD1,SYVN1,CLU,HES1,DNAJB1,CP
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FOXJ1,BMPR1A,FOXO1,SIM2,PLAGL2,ERG,PLAGX,PEG3,BHLHE40,SOX14
    DNA binding FAM170A,SET,MAFBA,ZNF785,ZFP641,E2F5,HDGF2,LHX6,TBX10,PRDM10
    receptor tyrosine kinase binding ZFP259,ANGPT4,ARHGEF16,FIZ1,ANGPT2,ANGPT2A,NRG3,TOB1,SHC3,SHC4
    ubiquitin protein ligase binding MAGEC2,SNCAIP,CCDC50,RNF34,NPLOC4,SMC6,YWHAZ,CKB,NDUFS2,MYOD1
    protein phosphatase binding MET,ERBB2,AP3B1,JAK3,SKAP1,VCP,HSP90B1,TRAF3,PPME1,PPARG

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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