Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Small cell lung cancer CYCS,CCNE2,PTGS2,TRAF2,AKT2,LAMA3,TRAF3,PTK2,NFKBIA,RELA
    Epstein-Barr virus infection SKP2,POLR3GL,PIK3R2,GSK3B,PTMA,EIF2AK1,HLA-G,GTF2B,TBPL1,HSPA1A
    Apoptosis CAPN1,CAPN2A,HIST1H1B,TNF,BADB,NTRK1,PRKAR1A,DIABLOB,PRKACG,IKBKG
    Endometrial cancer ILK,GSK3B,NRAS,CTNNA2,RAF1,BRAF,PIK3CA,PIK3CD,ARAF,ELK1
    Thyroid cancer RXRA,NRAS,TP53,MAPK1,BRAF,TPR,RXRB,TPM3,LEF1,CCND1
    Glioma AKT1,PTEN,PDGFB,PIK3CB,GRB2,NRAS,MAP2K1,SHC3,PLCG2,PLCG1
    Amyotrophic lateral sclerosis (ALS) MAPK13,GRIN1,MAPK11,Casp3,MAP2K3,RAC1,TNFRSF1A,TOMM40,APAF1,GRIA2
    MicroRNAs in cancer NOTCH2,CYP24A1,PLAU,FSCN1,PDCD4,APC,IKBKB,SOX4,CCNE2,RPS6KA5
    Proteoglycans in cancer PIK3R1,WNT8A,GAB1,FLNC,RDX,RHOA,STAT3,FZD6,WNT2,CD44

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PROM1,UBE2V2,APBA3,NUTF2,SUPT6H,FOXD3,UBOX5,LRRC47,RPAP3,MYBL2
    protein self-association NKX3,NKX3-1,EPB49,TMEM190,DYRK1A,ZSWIM2,VAMP2,MDH2,SHANK3,TTN
    protein C-terminus binding SAE1,PHB2,VPS4B,MED12,VGLL3,PIAS3,EP300,VTA1,YEATS4,BCL10
    ATP binding LIMK1,STK24A,HSPA4B,RHOBTB3,CSNK1E,DNAH6,NPR2,ATP8A1,TRPM6,ACTR1
    double-stranded DNA binding CRY1,FBXO18,APTX,DMC1,HMGB1,TP53,MTERF,RAD51AP1,XRCC5,XRCC6
    metal ion binding ZNF643,CPXCR1,ZNF713,INO80B,ZNF576.2,ZNF193,GNA14,ZXDC,ZNF45L,GALNTL6
    RNA polymerase II transcription factor binding DHX9,ID4,MTDH,SMAD4,ANKRD1,HCLS1,TEAD3,GATA3,ZFPM2A,ZFPM1
    MDM2/MDM4 family protein binding RFWD3,CDK5RAP3,CDKN2A,PPARA,PSME3,CAV1
    copper ion binding ATP7A,PAM,SNCA,F8,COMMD1,LOXL5A,P2RX2,HIST2H3A,S100V2,SNAI3

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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