Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epstein-Barr virus infection ENTPD1,POLR2E,EIF2AK4,PIK3R3,HLA-DQA1,POLR3G,PIK3R2,PIK3CB,NFKB2,TRAF1
    Thyroid hormone signaling pathway PRKACB,HDAC1,KAT2B,RXRA,PDPK1,PLCG1,TSC2,PLCD1,MAP2K1,SLC16A2
    Cell cycle GADD45AA,CHEK1,VRK1,CEP135,LEMD3,TUBGCP3,MCM8,MND1,CCNA2,CCNB3
    Small cell lung cancer APAF1,LAMA2,PTEN,LAMB1,PIK3R2,CCNE2,CKS2,ITGAV,LAMA5,LAMB4
    MAPK signaling pathway NGF,MKNK2B,CACNA1G,PPP3R1B,CACNG1A,PPM1AA,MECOM,CACNA1B,RRAS2,CACNG6A
    Endometrial cancer PIK3R5,TCF7,BAD,AKT2,MAP2K1,MLH1,FOXO3,ERBB2,GRB2,ELK1
    Non-small cell lung cancer MAP2K2,ALK,AKT2,PIK3CB,ERBB2,TGFA,STK4,BAD,CCND1,PIK3R1
    Glioma PLCG2,PTEN,PIK3R2,CAMK2D,AKT2,PIK3CA,SHC4,KRAS,PDGFRB,PIK3R1
    MicroRNAs in cancer SLC7A1,HNRNPK,SOCS1,WNT3,CDC25A,ZEB2,MMP9,FOXP1,SOX4,PDGFA

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    ubiquitin protein ligase binding AURKA,PER3,ERLIN2,AKTIP,CD40,Fzd4,BLZF1,SNX9,CUL3,UBE2U
    DNA binding STAT3,KIF4A,HOXC13,DMBX1A,ACD,DLX6A,CDT1,FAM171B,HLF,CDC5L
    protein C-terminus binding C11orf60,CEP120,VIM,HESX1,MKI67,FOXN3,PLEKHB1,PPP1R9B,DLG3,PROP1
    receptor tyrosine kinase binding PTPN14,SQSTM1,DOCK4,PTPN11,ANGPT2,ANGPT2A,FIZ1,NRG3,ANXA5,PCNA
    protein N-terminus binding TBL1XR1,SYNGR3,NCOA3,STX5A,NCOR2,TRAF6,KCNIP2,NTSR1,GTF2H2,TAF11
    protease binding VWF,RFFL,FADD,HSPA6,CCDC71L,UBC,SERPINB13,C10orf2,TIMP1,CAST
    copper ion binding CP,PRNP,METTL17,POLR1B,SCO2,PRNPA,SLC11A2,HEPHL1,LOXL2A,RNF7
    chaperone binding VWF,ATP1A2,DNAJB1,BAG5,Alb,DNAJA2L,PIH1D3,ATP1A3,GET4,BAG2
    enzyme binding RXRA,CASC3,AXIN1,KMT2E,GSTM2,IQCB1,KAT8,CUTA,CTNNB1,CBS

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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