Creative BioMart to Present at BPS 2025 Annual Meeting | February 15-19, 2025

Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl; bfy; bhy; p44; p53; Tp53;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • Fc
  • Avi
  • Myc
  • DDK
  • Non
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway, Sphingolipid signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayTGFBR1;HSP70;FGF1A;FGF18;FGF14;MAP2K2B;MECOM;CACNA2D2;AKT2L
Sphingolipid signaling pathwayLOC100328615;MAPK10;ASAH2;PPP2R1B;TRP53;NFKB1;PPP2R2A;PLD1;LASS5
Cell cycleDMC1;CEP76;PHF8;NUMA1;MCM5;CKAP5;TUBB4A;RAD9B;CDK11B
p signaling pathwayGADD45AA;CCNE2;RRM2B;CD82B;CASP9;CCNB3;BAXA;CYCS;Casp3
PIK-Akt signaling pathwayLAMB3;PDGFRB;IFNA8;GNG10;LAMA4;CREB5;G6PC2;IGF1;PPP2R1B
ApoptosisPTBP3;TNFRSF10A;CAPN2;MYD88;IRAK1;TNFSF10;Fasl;Casp3;DBNL
Wnt signaling pathwaySIAH1A;CHD8;CTBP2A;RAC3A;MYCB;TCF7L2;GSK3AA;RHOAC;PPP3R1B
Neurotrophin signaling pathwayPIK3CD;RPS6KA2;NFKBIE;RAF1;CALM3;IRS1;BAD;CAMK2D;SH2B3
Thyroid hormone signaling pathwayPIK3CA;MED12L;NCOR1;ATP1A4;NOTCH4;ESR1;BAD;KRAS;RXRA
Amyotrophic lateral sclerosis (ALS)BCL2;TP53;GRIN1;PPP3CC;NEFL;TNFRSF1B;GRIN2D;MAP2K6;CYCS
Huntingtons diseaseHIP1;COX8C;NDUFV3;DNAL1;VDAC3;CREB3L2;COX4I2;NDUFA7;APAF1
Hepatitis CSOCS3;CLDN7;PIK3R5;STAT2;KRAS;IFN-a;NFKBIA;IKBKB;MAPK8
Hepatitis BCASP10;PIK3CD;IFNA6;NFATC4;IFNA2;APAF1;CCNE1;CCNA1;MAP2K4
MeaslesPIK3CB;IFNA7;TNFRSF10D;PIK3R2;FAS;IRF3;CCNE1;IFNA21;TNFSF10
HTLV-I infectionHLA-C;TNFRSF13C;TBPL1;IL2RG;HLA-F;ANAPC4;HLA-E;WNT3;PIK3R2
Herpes simplex infectionSFRS9;IL15;HLA-DRA;ARNTL1B;SOCS3;TAF6;TAF3;HLA-DRB3;NFKBIAB
Epstein-Barr virus infectionPRKACB;FCER2;RB1;HLA-DQB1;HSPA8;PSMC2;EIF2AK2;RBPJ;MAPK9
Pathways in cancerFGF5;NOS2;Flt3l;EGLN1;ARAF;RXRA;TCEB1;HSP90AA1;GNGT2
Transcriptional misregulation in cancerCD14;CLSTN2;SFPI1;ASPSCR1;MEIS1;HIST2H3C1;REL;PLAU;MYCN
Viral carcinogenesisTTC6;RBPJL;KAT2B;GTF2A1L;CCNE2;DNAJA3;CDC20;RHOA;PKM
Proteoglycans in cancerWNT1;Ctsl;GPC1;PAK1;IL12B;WNT3A;FLNA;ERBB4;RAC1
MicroRNAs in cancerVEGFA;SIRT1;ATM;SOCS1;TRP53;VIM;KIF23;NOTCH3;TPM1
Colorectal cancerARAF;AKT2;Casp3;RHOA;PIK3R5;APC2;PIK3CA;MSH6;MAP2K1
Pancreatic cancerPIK3CA;KRAS;BRAF;NFKB1;STAT1;PIK3CD;TRP53;VEGFA;AKT2
Endometrial cancerPDPK1;FOXO3;AKT1;APC;PIK3R1;PIK3CG;APC2;CTNNA3;MAP2K1
GliomaPDGFRB;Pdgfa&Pdgfb;CCND1;PIK3CD;PIK3R5;CALM4;RB1;MAP2K2;PLCG2
Prostate cancerPDPK1;ERBB2;AKT1;LEF1;TCF7L2;PIK3CG;BRAF;Ar;RB1
Thyroid cancerTPM3;CCDC6;NTRK1;PAX8;HRAS;TPR;BRAF;NRAS;TCF7L2
Basal cell carcinomaPTCH1;APC;GSK3B;FZD10;WNT8B;WNT16;WNT9A;WNT5B;FZD7
MelanomaFGF13;FGFR1;IGF1;PIK3R3;FGF11;Pdgfa&Pdgfb;FGF9;MAP2K1;BRAF
Bladder cancerDAPK2;ERBB2;DAPK1;EGF;CCND1;TYMP;ARAF;HBEGF;MAP2K1
Chronic myeloid leukemiaABL1;PIK3CD;PIK3R3;GRB2;TGFBR1;IKBKB;PIK3R5;TGFB1;NFKBIA
Small cell lung cancerFHIT;LAMA5;LAMC1;LAMB4;LAMB1;PIK3CD;BIRC7;PIAS2;LAMA3
Non-small cell lung cancerRB1;TRP53;FOXO3;GRB2;PIK3CA;PIK3R1;PIK3R2;ARAF;HRAS
Central carbon metabolism in cancerPDGFRB;AKT1;PKM2;HRAS;NTRK3;PDGFRA;NTRK1;PDHA1;MAPK1

Trp53 has several biochemical functions, for example, ATP binding, DNA binding, MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPRKCH;PLK2B;PSMC3;ABCG4B;PRKAG1;ATP9B;IRAK1;ERBB3A;MYO1F
DNA bindingZBTB9;YBX1;NR1D2B;HIST1H111R;DNAJC2;PAX2B;HOXA9A;POLA2;ZNF560
MDM2/MDM4 family protein bindingCAV1;PSME3;CDK5RAP3;PPARA;TRP53;RFWD3;CDKN2A
RNA polymerase II core promoter sequence-specific DNA bindingSTAT6;EP300;TFAP2A;TRP53;SP1;HNF4A;SMAD5;EGR1;NLRC5
RNA polymerase II regulatory region sequence-specific DNA bindingPHF21B;TAL2;ELF5;ZNF711;ONECUT3;ZBTB11;ETV6;IRF2;ATF4
RNA polymerase II transcription factor activity, sequence-specific DNA bindingFOXG1C;SIX1A;FOXE1;MED1;ZNF444;TP73;ZNF576;FOXI3B;SIM1
RNA polymerase II transcription factor bindingTP53;ZFPM2;GATA2;ANKRD1;KLF4;MEF2A;TRPS1;GATA4;SFPI1
chaperone bindingCTSC;PARK2;PACRG;HYOU1;AHSA2;SLC25A17;UBL4;USP13;ST13
chromatin bindingREST;CNBPA;POLG;NR5A1A;TOX;EBF2;FOXC1A;NFATC3;MBD1
copper ion bindingMETTL17;SNAI3;CUTC;SCO2;SERPINB1A;RNF7;TYRP1;ATOX1;SNCA
core promoter sequence-specific DNA bindingRORA;SOX9;ZFP932;GATA3;MTA1;NR1D1;TOP1;ZFP750;ZFHX3
damaged DNA bindingAPEX1;RAD1;GTF2H3;RAD23B;DCLRE1A;HMGB2;TRP53;MPG;TP73
double-stranded DNA bindingHLF;DDX58;MTERF2;MTERF3;CTNNB1;HMGB3;MTERF;SP1;CRY1
enzyme bindingUGT1A1;CAT;CYP2E1;TSPYL1;CYP1A1;TULP3;TRP53;RCOR1;LDB1
histone acetyltransferase bindingETS1;TAF7;NR4A3;MTF1;EID1;CREB1;ZBTB7A;TAF7L;HIF1A
histone deacetylase regulator activityNCOR1;TP53;MAPK8;TRP53
identical protein bindingCHEK2;VIM;S100A1;CREBZF;LCK;BCAT1;FAM108A1;ZBTB16;IMPA1
metal ion bindingNME7;PRICKLE1A;PFKL;SDF4;TRIM35-24;MOB3C;GM5136;PTS;HBA-X
p53 bindingZNF385D;SMYD2;TAF1;DAXX;RNF20;CHD8;RFFL;RFWD3;GSK3B
protease bindingFURIN;NFRKB;CRADD;BCL10;SEMG2;RFFL;Casp3;Cstb;SERPINA1A
protein C-terminus bindingCDC37;SREBF2;ATP1B1;VGLL3;NPAT;NEFL;HESX1;LIG4;ERBB2
protein N-terminus bindingNCOA3;EXOC5;UNC13A;ERCC2;TRAF6;ACOX1;DAXX;PEX14;NCOR2
protein bindingEGR1;AP1B1;MFN1;SYT11;NSFL1C;MCC;CD82;C8orf74;PLD1
protein heterodimerization activityNEUROD2;CYBA;NEFL;MLXIPL;CLCN3;TAF4B;ADRA1B;HIST1H3F;AHR
protein kinase bindingAKAP5;PTPRK;SV2A;DBF4B;HSP90AB1;CDK5RAP1;CD226;LAX1;CDH2
protein phosphatase 2A bindingEIF4EBP1;STRN4;ARPP19;PPP2R2A;CTTNBP2NL;PPME1;TP53;FOXO1;HMGCR
protein phosphatase bindingRPA3;Itga10&Itgb1;KCNN4;PPARG;GNB2L1;MVP;JUP;HSP90B1;CDKN1B
protein self-associationCNTN2;AGTR1B;PCSK9;TNFAIP3;TRP53;RSAD2;ZNF496;ZKSCAN17;MDH2
receptor tyrosine kinase bindingTRP53;ANGPT2A;NCK1;PCNA;PTPN11;DNAJA3;MYOC;FNTA;FIZ1
sequence-specific DNA bindingFOXA;DBX2;MAFG;POU2F1B;FOXL2;NKX1.2LA;DBX1A;NKX3-1;HOXC8A
transcription cofactor bindingTRP53;FOXO3;CHD6;KLF4
transcription factor activity, sequence-specific DNA bindingWT1;RORCA;SS18L1;RXRBA;SALL3;IRF6;NFE2L2A;ZNF583;POU3F1
transcription factor bindingFIGLA;FOXA3;NFATC4;SUMO1;PAX6;H2-AB1;BCL3;APBB1;HDAC11
transcription regulatory region DNA bindingARID5A;CCNT1;ZNF335;ZBTB14;RNF10;ATF3;KLF17;SMAD3;WNT11
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingPLAG1;FOXA1;NFKB2;CAMTA1;TFAP4;HOXC13;GLI3;ZFAT;HLTF
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGRHL3;IKZF3;BARX2;GATA6;GATA2B;PLAGL1;EP300;GATA2A;MYOD1
ubiquitin protein ligase bindingDLG3;FAF1;EGR2;TRIM37;PIAS1;MC4R;SLC25A5;AXIN1;ERBB2

Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

lt_sv40; atp; Mdm2

Research Area

Related articles

Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).
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