Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle AKAP9,STAG2A,RAD21,CDC45,DULLARD,TUBB4A,TUBGCP5,SPO11,NCAPH2,CLIP1
    Small cell lung cancer APAF1,AKT2,TRAF5,PTEN,PIK3R5,BCL2L1,CYCS,PTK2,LAMB1,PIK3R2
    Central carbon metabolism in cancer MTOR,PIK3CG,RET,AKT2,HRAS,HKDC1,TP53,PDHA2,NRAS,G6PDX
    Measles HSPA2,MYD88,RCHY1,SH2D1A,TLR2,CD3E; CD3D,EIF3H,IFNA7,MX1,IFNG
    Hepatitis C PPP2CA,NR1H3,TRAF6,IRF3,IFNA1,CLDN15,KRAS,RIPK1,IFN-a,Ifna11
    Sphingolipid signaling pathway PPP2R1A,DEGS2,MAP2K2,GNAI3,FCER1G,ROCK1,MAPK12,PPP2R5A,BID,SGPP2
    Huntingtons disease POLR2J3,NDUFC2-KCTD14,NDUFB6,NDUFA13,UQCRC2,DCTN4,DNAH6,ATP5G3,BDNF,TBPL1
    Viral carcinogenesis VDAC3,HDAC11,TTC6,PIK3CD,HIST1H4N,PRKACB,HIST1H2BN,PIK3R2,ATF4,DDX3X
    PIK-Akt signaling pathway ANGPT4,CREB3L2,PPP2CB,PIK3R5,VEGFA,INS,CREB3L1,MDM2,LAMB3,PHLPP1

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    histone deacetylase regulator activity MAPK8,NCOR1,TP53
    transcription factor activity, sequence-specific DNA binding IKZF2,KLF4,RORAB,UBP1,PAX6,FBXW7,KAT7B,NKX2-1,MECP2,ZFP184
    RNA polymerase II regulatory region sequence-specific DNA binding ZFP551,PHF21B,AEBP1,ZNF561,SP5,STOX1,GATA2A,CSDA,DLX2,NHLH1
    transcription factor binding RBL1,E2F4,LMO4,DIP2C,NLRP3,BPTF,NKX2-1,LCOR,KAT8,PURA
    DNA binding ZNF383,TXLNB,CENPA,RARGB,ZNF654,NKX1.2LB,UNCX4.1,NR4A2,ZFP382,CEBPB
    histone acetyltransferase binding CEBPB,TAF7L,HIF1A,EID1,PAX6,PCNA,MEF2A,ETS1,CREB1,GLI3
    chaperone binding HSP104,HSCB,CDC37,TG,DNAJA3B,TSC1,STIP1,BAG3,DNAJC3,UBL4
    transcription regulatory region DNA binding SNCA,WNT1,YY1,RNF10,SALL3B,TAF7L,MLL1,STAT3,BCL11B,SERPINB1A
    identical protein binding RYR2,TPRG1L,TYSND1,MUL1A,TRIP13,IGF2R,DDX58,CHMP4B,TRP63,TTC32

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All Trp53 Products

    Required fields are marked with *

    My Review for All Trp53 Products

    Required fields are marked with *