Trp53

  • Official Full Name

    transformation related protein 53

  • Synonyms

    bbl;bfy;bhy;p44;p53;Tp53

Recombinant Proteins

  • Mouse
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc

    Involved Pathway

    Trp53 involved in several pathways and played different roles in them. We selected most pathways Trp53 participated on our site, such as MAPK signaling pathway,Sphingolipid signaling pathway,Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trp53 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway PFKFB2,NOTCH1,RXRB,MAPK1,RCAN2,ATP1A4,NCOA1,ATP2A2,WNT4,SLC16A10
    MAPK signaling pathway RELA,MAPKAPK2A,MAPK1,BDNF,TAOK1,ARRB2,FGF7,MEF2C,DUSP16,FGF11
    Chronic myeloid leukemia PIK3CG,RUNX1,NFKBIA,PIK3R2,SOS1,BCR,CDK6,BCL2L1,MAPK1,CBLC
    Sphingolipid signaling pathway MAPK8,ASAH1,PIK3CB,DEGS1,PLCB3,MAPK13,PPP2R5D,TRADD,S1PR2,GNAI2
    Thyroid cancer MAPK1,CCND1,PAX8,HRAS,CDH1,MAP2K2,TCF7L2,RXRB,NTRK1,NRAS
    PIK-Akt signaling pathway COL27A1,FGF6,ITGA3,IFNA21,SPP1,IFNAR1,PHLPP1,PTK2,CCND1,GNG13
    Central carbon metabolism in cancer PIK3CD,PIK3R5,MAP2K1,HRAS,SCO2,PFKL,AKT2,MTOR,MET,SIRT3
    Endometrial cancer ARAF,PIK3R5,PIK3CA,PTEN,AXIN2,TCF7L2,ELK1,FOXO3,GRB2,MAP2K2
    Bladder cancer MYC,TYMP,DAPK1,MMP1A,MAP2K1,MMP9,RB1,UPK3A,CDK4,MDM2

    Protein Function

    Trp53 has several biochemical functions, for example, ATP binding,DNA binding,MDM2/MDM4 family protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Trp53 itself. We selected most functions Trp53 had, and list some proteins which have the same functions with Trp53. You can find most of the proteins on our site.

    Function Related Protein
    protein binding NDFIP1,STX6,PACSIN2,APLP2,TRIM27,KLF6,CD163,R3HDM2,SRM,SEPT5
    transcription factor activity, sequence-specific DNA binding MYOG,IRF4A,SMAD6,RXRBA,POU3F2,TEFA,THRB,PPARA,CSRNP3,ZNF436
    protein self-association DYRK1A,ACHE,NKX3-1,RYR2,SVIP,ADAM8,CBR2,BCL10,SHANK3,EPB49
    RNA polymerase II transcription factor binding CREBBP,GATA2A,NFATC1,GATA2B,MKX,ZFPM2A,GATA3,TBX6,KLF4,SPOP
    RNA polymerase II transcription factor activity, sequence-specific DNA binding FOXO3B,FOXO4,ELF3,FOXO6,SP1,FEV,PAX6,ZNF446,FOXB1A,ETV3
    enzyme binding TNKS2,DVL1,PRTN3,LAMB1,CREB1,UGT1A1,APBA3,UGT1A9,PGR,GSTM4
    DNA binding HES4,RYBPB,LUC7L3,ZBTB9,ZNF580,POU2AF1,ISL1L,TCF7L1B,FLI1B,GEN1
    protein C-terminus binding ERCC2,MSH2,YEATS4,SNX17,ID1,MAP3K7,HSPB7,YWHAB,VGLL2,MED12
    protein N-terminus binding BIRC2,VWF,TGFB1,ERCC4,MYO7A,RND2,RELA,TBL1XR1,DAXX,STXBP1

    Interacting Protein

    Trp53 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trp53 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trp53.

    lt_sv40;atp;Mdm2

    Resources

    References

    • Du, SS; Bouquet, S; et al. Attenuation of the DNA Damage Response by Transforming Growth Factor-Beta Inhibitors Enhances Radiation Sensitivity of Non-Small-Cell Lung Cancer Cells In Vitro and In Vivo. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 91:91-99(2015).
    • Keenan, BP; Saenger, Y; et al. A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice. GASTROENTEROLOGY 146:1784-+(2014).

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