Cells Involved in Inflammation

Creative BioMart Cells Involved in Inflammation Product List

Cells Involved in Inflammation Background

Available Resources for the Study of Cells Involved in Inflammation

• At Creative BioMart, we understand the importance of cells involved in inflammation research and aim to provide researchers with high-quality products and resources to advance their research in this field. Our product portfolio includes recombinant proteins and other products that are important tools for understanding the function and mechanisms of inflammation-related cells.
• Our team of experts consists of individuals with extensive knowledge and expertise in the cells involved in inflammation research. They are committed to providing personalized solutions to meet the specific requirements of each researcher.
• In addition to our products, we offer a comprehensive collection of resources to further support your research on inflammation-related cells. Our resources include detailed information on the involved pathways, protein functions, interacting proteins, relevant research articles, and other valuable information. These resources are designed to provide researchers with a comprehensive understanding of the cells involved in inflammatory biology and enhance their research outcomes.

About Cells Involved in Inflammation

Inflammation is a vital immune response that occurs when the body's tissues are damaged or infected. It involves a complex interplay of various cell types that work together to eliminate pathogens, remove damaged cells, and initiate tissue repair. Here is a brief introduction to the key cells involved in inflammation:

• Dendritic Cells: Dendritic cells are specialized antigen-presenting cells that play a central role in initiating immune responses. They capture antigens from infected or damaged tissues, process them, and present them to T cells, triggering an adaptive immune response. Dendritic cells act as messengers between the innate and adaptive immune systems, helping to activate other immune cells.
• Mast Cells: Mast cells are resident cells found in connective tissues and mucosal surfaces. They contain granules filled with inflammatory mediators, such as histamine and cytokines. When activated by allergens, pathogens, or immune signals, mast cells release these mediators, leading to vasodilation, increased vascular permeability, and recruitment of other immune cells to the site of inflammation.
• Megakaryocytes: Megakaryocytes are large bone marrow cells responsible for platelet production. Although primarily known for their role in blood clotting, megakaryocytes also contribute to inflammation. They release pro-inflammatory mediators, interact with immune cells, and participate in platelet-mediated inflammation, influencing the overall inflammatory response.
• Monocytes/Macrophages: Monocytes are circulating immune cells that can differentiate into macrophages upon entering tissues. Macrophages are versatile phagocytic cells that engulf and destroy pathogens, debris, and dead cells. They also produce a wide range of inflammatory mediators, including cytokines and chemokines, which help recruit and activate other immune cells. Macrophages play a critical role in tissue repair and remodeling during inflammation.
• Myeloid-derived Suppressor Cells (MDSCs): MDSCs are a heterogeneous population of immature myeloid cells that emerge during inflammation and cancer. They possess immunosuppressive properties and can inhibit the activity of T cells and other immune cells. MDSCs accumulate in inflamed tissues and contribute to the regulation of immune responses, although their exact mechanisms are still being studied.

These cells represent a subset of the many different cell types involved in inflammation. They work in concert with other immune cells, such as neutrophils, T cells, and B cells, to mount an effective immune response and restore tissue homeostasis. Understanding the functions and interactions of these cells is crucial for elucidating the mechanisms underlying inflammation and developing targeted therapies.

Fig.1 Macrophage role in inflammation and tissue repair. (Abdulkhaleq LA, et al., 2018)
Upon stimulus, monocytes and resident macrophages activate. They remove tissue debris and produce inflammatory signals that promote the inflammatory response. Macrophages produce a wide array of cytokines, chemokines, and growth factors that promote inflammation, its regulation, and the successful restoration of tissue. They also participate in the regulation of inflammation by removing apoptotic neutrophils, an important process in turning the inflammatory process to one of tissue replacement and remodeling, apoptotic neutrophils that are not removed can undergo necrosis, spilling their toxic content, and perpetuating the inflammatory response.

Common Inflammation and Cells Involved in Inflammation

• Rheumatoid arthritis: This is an autoimmune disease characterized by chronic inflammation of the joints. The key cells involved in the occurrence and development of inflammation in rheumatoid arthritis are T cells, B cells, and macrophages. T cells and B cells play a role in initiating and perpetuating an immune response, leading to the production of autoantibodies and immune complexes that contribute to joint inflammation. Macrophages are also involved in the inflammation process by releasing pro-inflammatory cytokines and enzymes.
• Inflammatory bowel disease (IBD): This includes disorders such as Crohn's disease and ulcerative colitis, which involve chronic inflammation of the gastrointestinal tract. In IBD, the key cells involved in inflammation are T cells, specifically CD4+ T helper cells and regulatory T cells. CD4+ T helper cells release pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17), which contribute to inflammation in the gut. Regulatory T cells, on the other hand, help maintain immune tolerance and downregulate the inflammatory response.
• Asthma: This is a chronic inflammatory disease of the airways. The key cells involved in the occurrence and development of inflammation in asthma are mast cells, eosinophils, and T cells. Mast cells play a central role in asthma by releasing mediators like histamines and leukotrienes, which cause airway constriction and inflammation. Eosinophils are recruited to the lungs and release inflammatory substances that contribute to airway inflammation. T cells, particularly T helper type 2 (Th2) cells, release cytokines that promote eosinophilic inflammation and the production of immunoglobulin E (IgE).
• Psoriasis: This is a chronic inflammatory skin condition characterized by red, scaly patches. In psoriasis, the key cells involved in inflammation are T cells, dendritic cells, and keratinocytes. T cells, specifically CD4+ T cells, are activated and release pro-inflammatory cytokines, such as interleukin-17 (IL-17) and tumor necrosis factor-alpha (TNF-alpha). These cytokines stimulate dendritic cells to produce more cytokines and recruit other immune cells to the affected area. Keratinocytes, which are the main cells found in the outermost layer of the skin, also play a role in psoriasis inflammation by secreting pro-inflammatory mediators and growing at an accelerated rate.

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Reference:

1. Abdulkhaleq LA, Assi MA, Abdullah R, Zamri-Saad M, Taufiq-Yap YH, Hezmee MNM. The crucial roles of inflammatory mediators in inflammation: A review. Vet World. 2018;11(5):627-635. doi:10.14202/vetworld.2018.627-635