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Official Full Name ATPase, Na+/K+ transporting, alpha 3 polypeptide
Background The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of;Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the;electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for;osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical;excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a;smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene;encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for;this gene.
Synonyms ATP1A3; ATPase, Na+/K+ transporting, alpha 3 polypeptide; dystonia 12 , DYT12; sodium/potassium-transporting ATPase subunit alpha-3; Alpha(III); AT1A3_HUMAN; ATPase Na+/K+ transporting alpha 3 polypeptide; DYT 12; DYT12; MGC13276; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+/K+ ATPase 3; Na+/K+ ATPase alpha 3 subunit; RDP; Sodium potassium ATPase alpha 3 polypeptide; Sodium pump 3; Sodium pump subunit alpha-3; Sodium/potassium transporting ATPase alpha 3 chain; sodium-potassium-ATPase, alpha 3 polypeptide; sodium/potassium-transporting ATPase alpha-3 chain
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP1A3-366H Recombinant Human ATP1A3 Mammalian Cell His
    Human ATP1A3-8611HCL Recombinant Human ATP1A3 293 Cell Lysate HEK293 N/A
    Human ATP1A3-963H Recombinant Human ATP1A3 protein, GST-tagged Wheat Germ GST
    Rat ATP1A3-854R Recombinant Rat ATP1A3 Protein Mammalian Cell His
    Rhesus Macaque ATP1A3-448R Recombinant Rhesus monkey ATP1A3 Protein, His-tagged Mammalian Cell His
    Chicken ATP1A3-7024C Recombinant Chicken ATP1A3 Mammalian Cell His

    ATP1A3 involved in several pathways and played different roles in them. We selected most pathways ATP1A3 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway Adcy4; PIK3CA; CALM2; MAPK3; CALML5; INS; NFATC1; BNP; GUCY1A3; PPIF
    cAMP signaling pathway PRKACA; GNAI3; CALML3; ATP1A3; CAMK2B; PPP1CA; NPR1; GRIN2B; HTR4; GIPR
    Cardiac muscle contraction TNNT2; CACNB2A; CACNG6A; CACNA2D4; TPM2; ATP1B4; MYL4; CACNG3; COX7B; CACNA1DA
    Adrenergic signaling in cardiomyocytes PLN; PIK3R5; CREB3L4; KCNQ1; PPP1R1A; KCNE1; ADCY9; AGTR1B; AKT2; SCN5A
    Insulin secretion GPR119; ADCYAP1; PLCB1; PRKCB; INS2; STX1A; FXYD2; SNAP25; KCNMB3; PRKCG
    Thyroid hormone synthesis ATF4; PLCB1; ATP1B1; SLC26A4; FXYD2; PRKACB; CREB3L2; PRKACA; ATP1A4; GPX8
    Thyroid hormone signaling pathway NCOA1; PLCD1; PRKACA; TP53; PFKP; THRA; MED24; RXRG; SIN3A; CCND1
    Aldosterone-regulated sodium reabsorption SCNN1B; ATP1A3; PRKCG; INS1; IRS1; ATP1A2; PIK3CA; MAPK3; KCNJ1; PRKCA
    Endocrine and other factor-regulated calcium reabsorption PLCB2; TRPV5; PLCB1; KLK1B26; GNAS; PRKACG; DNM3; PRKACB; ESR1; PRKACA
    Proximal tubule bicarbonate reclamation GLUD2; PCK2; ATP1A1; SLC4A4; ATP1B3; CA2; GLS; ATP1A2; ATP1B1; ATP1A3
    Salivary secretion AQP5; CALM2; Adcy4; Slc4a2; ATP1A4; ATP1B4; PRH1; PRKG1; CALML5; KCNN4
    Gastric acid secretion SSTR2; SLC9A1; ATP1A3; ACTB; MYLK; ATP1B3; Car2; CALM2; CALM3; ATP1B4
    Pancreatic secretion PLA2G10; Slc4a2; Adcy4; RAB3D; LOC780933; ATP1B2; RAB8A; SLC9A1; ITPR3; CLCA3
    Carbohydrate digestion and absorption G6PC; G6PC2; TAS1R2; PIK3CD; AMY1A; Amy1; SLC5A1; HK2; AMY2B; PIK3CB
    Protein digestion and absorption COL18A1; ATP1B1; ATP1B2; SLC15A1; ATP1B4; ATP1A4; COL13A1; ATP1A1; SLC9A3; ATP1A2
    Bile secretion ABCB1; SLC22A7; SLC10A2; NCEH1; ABCC2; CFTR; ABCB4; SLC22A8; AQP8; PRKACA
    Mineral absorption TRPV6; SLC31A1; ATP1A3; SLC8A1; MT2A; MT1E; MT1H; MT1X; SLC46A1; CYBRD1

    ATP1A3 has several biochemical functions, for example, ATP binding, D1 dopamine receptor binding, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A3 itself. We selected most functions ATP1A3 had, and list some proteins which have the same functions with ATP1A3. You can find most of the proteins on our site.

    Function Related Protein
    D1 dopamine receptor binding AGTR1A; ARRB2; ATP1A3; DLG4; CAV2; DRD3; PTPN11; GNAS
    chaperone binding ATP1A2; TSC1; TIMM44; BAK1; VWF; GRPEL1; HSPE1; ATP1A1; CLU; CXorf41
    metal ion binding PPP4C; ZDHHC6; SP9; CYP7A1A; ZNF671; RAB11FIP4; ZFP41; VSNL1A; PGCP; CYP2X7
    sodium:potassium-exchanging ATPase activity ATP1A2; ATP1A3; ATP12A; ATP1A2A; ATP1A1A.4; ATP1A1A.5; ATP1A4; ATP1A1A.3; ATP1A1A.2; FXYD2
    steroid hormone binding ATP1A3; ESR2B; ATP1A1; ESR2A; NR3C1; ATP1A2; GPR30

    ATP1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A3.

    PCBD1; ATXN1; CASP8; 15-deoxy-delta(12,14; a52_vaccw; AGO2

    Murakami, Y; Ikeda, U; et al. Promoter of the Na,K-ATPase alpha 3 subunit gene is composed of cis elements to which NF-Y and Sp1/Sp3 bind in rat cardiocytes. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1352:311-324(1997).

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