ATP6V0C

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ATP6V0C

Official Full Name ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
Background This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17.
Synonyms ATP6V0C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATP6C, ATP6L, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD , ATPL; V-type proton ATPase 16 kDa proteolipid subunit; VATL; Vma3; ATP6C; ATP6L; ATPase, H+ transporting, lysosomal, V0 subunit c; ATPL; V ATPase subunit c; Vacuolar ATP synthase 16 kDa proteolipid subunit; Vacuolar H+ ATPase proton channel subunit; Vacuolar proton pump, 16 kDa subunit; V-ATPase 16 kDa proteolipid subunit; vacuolar proton pump 16 kDa proteolipid subunit; H(+)-transporting two-sector ATPase, 16 kDa subunit; VPPC
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ATP6V0C-4978H Recombinant Human ATP6V0C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Atp6v0c-678M Recombinant Mouse Atp6v0c Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human ATP6V0C-8589HCL Recombinant Human ATP6V0C 293 Cell Lysate HEK293 N/A
    Human ATP6V0C-996H Recombinant Human ATP6V0C protein, GST-tagged Wheat Germ GST
    Rat ATP6V0C-886R Recombinant Rat ATP6V0C Protein Mammalian Cell His
    Chicken ATP6V0C-5306C Recombinant Chicken ATP6V0C Mammalian Cell His

    ATP6V0C involved in several pathways and played different roles in them. We selected most pathways ATP6V0C participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation COX6B2; PPA1B; NDUFS8A; ATP6V1D; NDUFAB1; ATP6V1E1; ATP6V0D1; ATP6V0CB; NDUFS3; COX7A2L
    Metabolic pathways CYP3A25; CHSY3; ST6GALNAC3; PGAM1; FUT6; SGPL1; MAN1B1; AKR1B1L; FBP2; ADSL
    Lysosome MAN2B1; LAPTM5; SGSH; AP4E1; AP1G2; PSAP; SLC17A5; AP1M3; CTSF; ASAH1
    Phagosome cgr2b; ATP6V1B2; TUBA8L3; BMA2; MPO; DYNC1I2A; ATP6V1B1; ATP6V0E2; ATP6V0CA; SEC22BA
    Synaptic vesicle cycle NAPA; ATP6V0C; NSF; STX2; ATP6V1H; ATP6V1G2; SLC17A7; ATP6V0D1; ATP6V0A1; SLC17A6
    Collecting duct acid secretion ATP6V1G3; ATP6V1E2; ATP6V0D1; ATP6V1G1; ATP6V1A; ATP6V0D2; ATP6V1B2; ATP6V0E; SLC12A7; ATP6V1G2
    Vibrio cholerae infection MUC2; ATP6V1B2; ATP6V1E2; PLCG1; ATP6V1G1; KDELR3; TJP1; ATP6V1D; PRKACA; TJP2
    Epithelial cell signaling in Helicobacter pylori infection ATP6V1A; ATP6V1E1; ATP6V1F; ATP6V1H; CCL5; ATP6V0D1; ATP6V0D2; MAPK13; MAPK8; ATP6V0A1
    Tuberculosis RAB5B; AKT1; IFNA4; HLA-DQA2; NFYB; HLA-DMB; CD74; TRADD; CAMP; ATP6V0C
    Rheumatoid arthritis IL15; IL18; CXCL5; IL1A; TLR4; HLA-DOB; ATP6V0A4; IFNG; ATP6V0A1; ATP6V1D

    ATP6V0C has several biochemical functions, for example, protein binding, proton-transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0C itself. We selected most functions ATP6V0C had, and list some proteins which have the same functions with ATP6V0C. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SARM1; GOLSYN; HOOK3; GGA2; SEPT2; HOMER1; ZNHIT6; SLC25A4; RNASE1; ATF7IP
    proton-transporting ATP synthase activity, rotational mechanism ATP6AP1B; ATP5C1; ATP5B; ATP6V0C; ATP5A1; ATP5O; ATP6AP1; ATP5E
    proton-transporting ATPase activity, rotational mechanism ATP6V0B; ATP5D; ATP6V1F; ATP5A1; ATP6V1B2; TCIRG1; ATP6V0C; ATP6V0A4; ATP6V1E1; ATP6V0CB
    ubiquitin protein ligase binding CASP8; MAGEA2B; BID; BAG6; UQCRC1; SMC6; CUL5A; FAF1; RIPK1; MFN2

    ATP6V0C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0C here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0C.

    CERS2; MSR1; PSMA3; EDA; SMIM3; PDGFRB; E5; CLIC1; MARK3

    Mangieri, LR; Mader, BJ; et al. ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease. PLOS ONE 9:-(2014).
    Pavelin, J; Reynolds, N; et al. Systematic MicroRNA Analysis Identifies ATP6V0C as an Essential Host Factor for Human Cytomegalovirus Replication. PLOS PATHOGENS 9:-(2013).

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