atp6v0c
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  • Official Full Name
  • ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
  • Background
  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17.
  • Synonyms
  • ATP6V0C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATP6C, ATP6L, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD , ATPL; V-type proton ATPase 16 kDa proteolipid subunit; VATL; Vma3; ATP6C; ATP6L; ATPase, H+ transporting, lysosomal, V0 subunit c; ATPL; V ATPase subunit c; Vacuolar ATP synthase 16 kDa proteolipid subunit; Vacuolar H+ ATPase proton channel subunit; Vacuolar proton pump, 16 kDa subunit; V-ATPase 16 kDa proteolipid subunit; vacuolar proton pump 16 kDa proteolipid subunit; H(+)-transporting two-sector ATPase, 16 kDa subunit; VPPC
Cat.#:ATP6V0C-996HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ATP6V0C protein, GST-tagged
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Cat.#:ATP6V0C-886RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ATP6V0C Protein
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Cat.#:ATP6V0C-5306CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ATP6V0C
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Cat.#:ATP6V0C-8589HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ATP6V0C 293 Cell Lysate
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Involved Pathway

ATP6V0C involved in several pathways and played different roles in them. We selected most pathways ATP6V0C participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
ATP5D; PPA1A; ATP6V1BA; ATP5IA; Atp5g2; NDUFV1; NDUFAB1; ATP6V0D2; NDUFB2; MT-ND1
Metabolic pathways
UQCRFS1; HADHAA; GALNT9; COX8A; ALPL; SPTLC2B; C1GALT1A; GALNT10; CSGALNACT2; GDA
Lysosome
CTNS; ARSA; ATP6V1H; CTSZ; GALNS; AP3M1; CTSC; AP4M1; CD68; SORT1A
Phagosome
CD14; RAB5C; TUBB2; EEA1; NCF2; ATP6V1G2; FCGR3; CTSLA; ATP6V0E1; ATP6V0D1
Synaptic vesicle cycle
SNAP25; ATP6V0C; STX3; CPLX3; STX1B; ATP6V1H; DNM3; ATP6V0D1; UNC13C; ATP6V0D2
Collecting duct acid secretion
ATP6V0D2; ATP6V0D1; ATP6V1E2; CA2; SLC4A1; ATP6V1B2; ATP6V1G2; ATP6V0A1; ATP6V0E2; ATP6V0E1
Vibrio cholerae infection
KDELR2; ATP6V1A; ATP6V1E1; PRKACG; ATP6V0D2; PLCG2; ERO1L; TJP2; ATP6V0C; TJP1
Epithelial cell signaling in Helicobacter pylori infection
CDC42; MAPK11; IKBKG; TCIRG1; RELA; ATP6V1E2; CXCR1; ATP6V1E1; TJP1; MAP2K4
Tuberculosis
NFYC; ITGAX; SPHK2; IFNA10; SRC; TLR2; IFNA5; ATP6V0D2; NFKB1; ARHGEF12
Rheumatoid arthritis
IL15; ATP6V1C1; HLA-DQA1; ATP6V1G1; ATP6V0D1; Ccl12; ATP6AP1; IL18; TNFSF13; TLR2

Protein Function

ATP6V0C has several biochemical functions, for example, protein binding, proton-transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0C itself. We selected most functions ATP6V0C had, and list some proteins which have the same functions with ATP6V0C. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein FGFR4; NR0B1; EHMT1; TAF2; CTNNA1; FGFRL1B; ZFP110; OFD1; RPS25; RRAGD
Function proton-transporting ATP synthase activity, rotational mechanism
Related Protein ATP5C1; ATP5B; ATP5O; ATP6AP1B; ATP5A1; ATP6AP1; ATP5E; ATP6V0C
Function proton-transporting ATPase activity, rotational mechanism
Related Protein ATP6V0A1A; ATP6V1E1; TCIRG1; ATP6V0A2; ATP5A1; ATP6V0A2B; ATP6V0B; ATP6V0CA; ATP5D; ATP6V1E1B
Function ubiquitin protein ligase binding
Related Protein TRIB3; EGR2; AXIN1; SUMO1; ABI2; UBOX5; RIPK1; RFFL; GGN; RALB

Interacting Protein

ATP6V0C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0C here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0C.
CERS2; MSR1; PSMA3; EDA; SMIM3; PDGFRB; E5; CLIC1; MARK3

ATP6V0C Related Articles

Mangieri, LR; Mader, BJ; et al. ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease. PLOS ONE 9:-(2014).
Pavelin, J; Reynolds, N; et al. Systematic MicroRNA Analysis Identifies ATP6V0C as an Essential Host Factor for Human Cytomegalovirus Replication. PLOS PATHOGENS 9:-(2013).