• Official Full Name
  • ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
  • Background
  • This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17.
  • Synonyms
  • ATP6V0C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATP6C, ATP6L, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD , ATPL; V-type proton ATPase 16 kDa proteolipid subunit; VATL; Vma3; ATP6C; ATP6L; ATPase, H+ transporting, lysosomal, V0 subunit c; ATPL; V ATPase subunit c; Vacuolar ATP synthase 16 kDa proteolipid subunit; Vacuolar H+ ATPase proton channel subunit; Vacuolar proton pump, 16 kDa subunit; V-ATPase 16 kDa proteolipid subunit; vacuolar proton pump 16 kDa proteolipid subunit; H(+)-transporting two-sector ATPase, 16 kDa subunit; VPPC
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ATP6V0C protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ATP6V0C Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ATP6V0C
Source (Host):Species:Human
Product nameRecombinant Human ATP6V0C 293 Cell Lysate

ATP6V0C Related Articles

Mangieri, LR; Mader, BJ; et al. ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease. PLOS ONE 9:-(2014).
Pavelin, J; Reynolds, N; et al. Systematic MicroRNA Analysis Identifies ATP6V0C as an Essential Host Factor for Human Cytomegalovirus Replication. PLOS PATHOGENS 9:-(2013).