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Recombinant Full Length Human ATP6V0C Protein, C-Flag-tagged

Cat.No. : ATP6V0C-2129HFL
Product Overview : Recombinant Full Length Human ATP6V0C Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
  • Specification
  • Gene Information
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Description : This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 15.6 kDa
AA Sequence : MSESKSGPEYASFFAVMGASAAMVF SALGAAYGTAKSGTGIAAMSVMRPE QIMKSIIPVVMAGIIAIYGL VVAVLIANSLNDDISLYKSFLQLGA GLSVGLSGLAAGFAIGIVGDAGVRG TAQQPRLFVGMILILIFAEV LGLYGLIVALILSTK TRTRPLEQKLISEEDLAANDILDYK DDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Transmembrane
Protein Pathways : Epithelial cell signaling in Helicobacter pylori infection, Lysosome, Metabolic pathways, Oxidative phosphorylation, Vibrio cholerae infection
Gene Name : ATP6V0C ATPase H+ transporting V0 subunit c [ Homo sapiens (human) ]
Official Symbol : ATP6V0C
Synonyms : ATPL; VATL; VPPC; Vma3; ATP6C; ATP6L
Gene ID : 527
mRNA Refseq : NM_001694.4
Protein Refseq : NP_001685.1
MIM : 108745
UniProt ID : P27449

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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