Recombinant Human ATP6V0C protein, GST-tagged

• Cat.No.: ATP6V0C-996H
• Product Overview: Human ATP6V0C full-length ORF ( NP_001685.1, 1 a.a. - 155 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 42.1 kDa
• AA Sequence: MSESKSGPEYASFFAVMGASAAMVF SALGAAYGTAKSGTGIAAMSVMRPE QIMKSIIPVVMAGIIAIYGLVVAVL IANSLNDDISLYKSFLQLGAGLSVG LSGLAAGFAIGIVGDAGVRGTAQQP RLFVGMILILIFAEVLGLYGLIVAL ILSTK
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c [ Homo sapiens ]
• Official Symbol: ATP6V0C
• Synonyms: ATP6V0C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATP6C, ATP6L, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD , ATPL; V-type proton ATPase 16 kDa proteolipid subunit; VATL; Vma3; V-ATPase 16 kDa proteolipid subunit; vacuolar H+ ATPase proton channel subunit; vacuolar proton pump 16 kDa proteolipid subunit; vacuolar ATP synthase 16 kDa proteolipid subunit; H(+)-transporting two-sector ATPase, 16 kDa subunit; ATPL; VPPC; ATP6C; ATP6L
• Gene ID: 527
• mRNA Refseq: NM_001198569
• Protein Refseq: NP_001185498
• MIM: 108745
• UniProt ID: P27449