• Official Full Name
  • Anthrax Toxin Receptor
  • Background
  • This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
  • Synonyms
  • ANTXR1; ATR; TEM8; FLJ10601; FLJ11298; FLJ21776; anthrax toxin receptor 1; OTTHUMP00000159975; OTTHUMP00000202140; OTTHUMP00000202171; tumor endothelial marker 8; 2310008J16Rik; 2810405N18Rik; anthrax toxin receptor; tumor endothelial marker 8 precursor
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ATR Protein, GST-tagged
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ATR protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ATR protein, His & T7-tagged

ATR Related Articles

Huebner, M; Ben Haddada, M; et al. Layer-by-layer generation of PEG-based regenerable immunosensing surfaces for small-sized analytes. BIOSENSORS & BIOELECTRONICS 67:334-341(2015).
Chen, HH; Hsiao, YC; et al. In situ fabrication of cleavable peptide arrays on polydimethylsiloxane and applications for kinase activity assays. ANALYTICA CHIMICA ACTA 865:53-59(2015).