Recombinant Human ATR Protein, GST-tagged

• Cat.No.: ATR-4932H
• Product Overview: Recombinant human ATR (2245-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
• Source: Insect cells
• Species: Human
• Tag: GST
• Molecular Mass: 70 kDa
• Purity: > 85%
• Applications: WB
• Stability: 1 year at -70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.5 μg/μl
• Storage Buffer: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Gene Information

• Gene Name: ATR
• Official Symbol: ATR ATR serine/threonine kinase [ Homo sapiens (human) ]
• Synonyms: FRP1; MEC1; SCKL; SCKL1; ATR; ATR serine/threonine kinase; FCTCS; serine/threonine-protein kinase ATR; FRAP-related protein-1; MEC1, mitosis entry checkpoint 1, homolog; ataxia telangiectasia and Rad3-related protein; EC 2.7.11.1
• Gene ID: 545
• mRNA Refseq: NM_001184
• Protein Refseq: NP_001175
• MIM: 601215
• UniProt ID: Q13535