• Official Full Name
  • butyrophilin-like 2 (MHC class II associated)
  • Background
  • Butyrophilin is a glycoprotein that is specifically expressed on the apical surface of mammary epithelial cells during lactation and becomes incorporated as an integral protein into the membrane of the milk fat globule during the budding and secretion of fat droplets into milk. BTNL2 (butyrophilin-like protein 2), also known as BTL-II, is a 455 amino acid single-pass type II membrane protein that acts as a negative regulator of T cell proliferation. Expressed in thymus, brain, kidney, heart, liver, small intestine, testis, ovary, pancreas and leukocytes, BTNL2 exists as at least six alternatively spliced isoforms, which are encoded by a gene located on human chromosome 6. Expression of BTNL2 isoform 3 is associated with susceptibility to sarcoidosis type 2 (SS2), an immune disorder that causes chronic inflammatory granulomatous lesions.
  • Synonyms
  • BTNL2; butyrophilin-like 2 (MHC class II associated); SS2; BTL-II; Btnl2; Butyrophilin like 2 MHC class II associated; Butyrophilin-like protein 2; DAAP-282D22.2; HSBLMHC1; BTN7; butyrophilin-like protein 2;
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BTNL2, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human BTNL2 protein, His-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human BTNL2, MIgG2a Fc-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human BTNL2, HIgG1 Fc-tagged
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse BTNL2, Fc-tagged

Btnl2 Related Articles

Rubicz, R; Yolken, R; et al. Genome-Wide Genetic and Transcriptomic Investigation of Variation in Antibody Response to Dietary Antigens. GENETIC EPIDEMIOLOGY 38:439-446(2014).
Herraez, DL; Martinez-Bueno, M; et al. Rheumatoid Arthritis in Latin Americans Enriched for Amerindian Ancestry is Associated With Loci in Chromosomes 1, 12, and 13, and the HLA Class II Region. ARTHRITIS AND RHEUMATISM 65:1457-1467(2013).