CMKLR1
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Official Full Name
chemokine-like receptor 1
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Overview
Activating CMKLR1 by an agonist mobilizes intracellular calcium and causes the activation of several other signaling cascades like the ERK1 and NF-κB. Initial studies of CMKLR1 suggested that it might have a role in the inflammatory pathways. Its cognate ligand, chemerin was found in joint aspirate from rheumatoid arthritis and absent in aspirate from degenerative arthritis. CMKLR1 expression by plasmacytoid dendritic cells and macrophages also helped foster this idea. In vitro chemotaxis assays showed it to be utilized in attracting these cells. As a adipokine receptor it has a role in adipogenesis and adipocyte maturation.It seems also to have a role in peripheral insulin resistance. -
Synonyms
CMKLR1; chemokine-like receptor 1; chemokine receptor-like 1; G-protein coupled receptor DEZ; G-protein coupled receptor ChemR23; orphan G-protein coupled receptor, Dez; DEZ; ChemR23; CHEMERINR; MGC126105; MGC126106;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rattus norvegicus (Rat)
- Zebrafish
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CMKLR1 Related Articles
- CMKLR1 Related Research Area
CMKLR1 involved in several pathways and played different roles in them. We selected most pathways CMKLR1 participated on our site, such as GPCRs, Class A Rhodopsin-like, which may be useful for your reference. Also, other proteins which involved in the same pathway with CMKLR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCRs, Class A Rhodopsin-like | ACKR4;FFAR3;OPN4;CCR9;SSTR4;NPFFR2;GPR27;OR10A5;RRH |
CMKLR1 has several biochemical functions, for example, G-protein coupled receptor activity, chemokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CMKLR1 itself. We selected most functions CMKLR1 had, and list some proteins which have the same functions with CMKLR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor activity | GPR148;TACR1B;FZD7A;GPR37;GPR26;OR52J3;OR1L1;CHRM5B;FPR2 |
| chemokine receptor activity | CMKLR1;CCR8;RGRB;CCR5;CX3CR1;CXCR3.1;CXCR4B;CCR9A;CXCR4A |
| protein binding | ERBB4;TNNI3;PPP6R2;CBR2;SIRT1;KCNIP2;BAG1;FKBPL;FAM195A |
| receptor activity | NRXN1;CD200R2;KRT1;XPR1;UNC13B;CD46;TLR6;NRXN3;VMN1R54 |
CMKLR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CMKLR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CMKLR1.
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