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CRH

  • Official Full Name

    corticotropin releasing hormone

  • Overview

    Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to;stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal;recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including;hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in;peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that;determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels;of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this;protein may act as a trigger for parturition.
  • Synonyms

    CRH; corticotropin releasing hormone; corticoliberin; corticotropin releasing factor; CRF; corticotropin-releasing factor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bacillus subtilis
  • Chicken
  • Human
  • Mouse
  • Rat
  • E. coli or Yeast
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CRH-7791H Recombinant Human CRH protein, His & GST-tagged E.coli His/GST His40~Gly195 (Accession # P06850)
Human CRH-3048H Recombinant Human Corticotropin Releasing Hormone, T7-tagged E.coli T7
Human CRH-107H Recombinant Human CRH, His-tagged E.coli His
Human CRH-217H Recombinant Human CRH protein, T7-tagged E.coli T7
Human CRH-183H Recombinant Human CRH Mammalian Cell His
Human CRH-108H Recombinant Human CRH, GST-tagged Wheat Germ GST
Human CRH-7281HCL Recombinant Human CRH 293 Cell Lysate HEK293 N/A
Human CRH-2730H Recombinant Human CRH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CRH-841H Recombinant Human CRH Protein, His&GST-tagged E.coli N-His&GST Ser154-Ile194
Human CRH-1806H Recombinant Human CRH Protein (His40-Gly195), N-His tagged E.coli N-His His40-Gly195
Human CRH-3467H Recombinant Human CRH protein, His-tagged E.coli His 53-156 aa
Human CRH-2730H-B Recombinant Human CRH Protein Pre-coupled Magnetic Beads HEK293
Mouse Crh-7792M Recombinant Mouse Crh protein, His-tagged E.coli His Arg28~Arg160
Mouse CRH-3901M Recombinant Mouse CRH Protein Mammalian Cell His
Mouse CRH-1974M-B Recombinant Mouse CRH Protein Pre-coupled Magnetic Beads HEK293
Mouse CRH-1974M Recombinant Mouse CRH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Crh-7793R Recombinant Rat Crh protein, His-tagged E.coli His Gln39~Lys187 (Accession # P01143)
Rat CRH-1596R Recombinant Rat CRH Protein Mammalian Cell His
Rat Crh-7794R Recombinant Rat Crh protein, His & GST-tagged E.coli His/GST Gln39~Lys187 (Accession # P01143)
Rat CRH-1253R-B Recombinant Rat CRH Protein Pre-coupled Magnetic Beads HEK293
Rat CRH-1253R Recombinant Rat CRH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bacillus subtilis CRH-0033B Recombinant Bacillus subtilis CRH protein, His-tagged E. coli or Yeast His
Chicken CRH-3836C Recombinant Chicken CRH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CRH Related Articles

CRH involved in several pathways and played different roles in them. We selected most pathways CRH participated on our site, such as Alcoholism, Class B/2 (Secretin family receptors), Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AlcoholismGRIN2C;H2AFV;HIST1H4H;BDNF;HIST3H2A;HIST1H2BG;HDAC3;NPY;HIST1H2BH
Class B/2 (Secretin family receptors)CRH;ADCYAP1B;RAMP3;EMR2;CALCA;SETD6;RAMP1;CD97;CALCRL
Corticotropin-releasing hormoneTRIM28;CRHR2;IVL;TBX19;PARP1;ADRBK2;JUND;TCF4;CASP12
G alpha (s) signalling eventsGCGA;PDE10A;ADCYAP1R1;CALCB;ADM;TAAR1;PTHRP2;ADORA2A;VIP2
GPCR downstream signalingRAMP3;PTHLH;RHOGA;CYSLTR1;TAE1;PTHRP2;GNA13;CCR6;OR4D2
GPCR ligand bindingGPR37B;GPR65;OPN4A;RLN3A;AGT;PTH;EDNRA;OXER1;PTHRP2
Long-term depressionPPP2CB;GNA12;RAF1;GUCY1B3;PLCB4;RYR1;NRAS;GNAI1;ITPR1
Myometrial Relaxation and Contraction PathwaysACTA1;MAFF;GABPA;RGS17;RXFP2;GPR182;RGS4;CNN2;IGFBP5

CRH has several biochemical functions, for example, corticotropin-releasing hormone receptor 1 binding, corticotropin-releasing hormone receptor 2 binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CRH itself. We selected most functions CRH had, and list some proteins which have the same functions with CRH. You can find most of the proteins on our site.

Function Related Protein
corticotropin-releasing hormone receptor 1 bindingCRH;UCN;GNAO1B;GNAS;GNAO1;GNAO1A
corticotropin-releasing hormone receptor 2 bindingUCN;UCN2;CRH;UCN3;UCN3L
hormone activityPRL3B1;UCN3;PRL7A1;GNRH2;INS2;PRL8A9;PRL5A1;MLN;IGF3
neuropeptide hormone activityCORT;NPFF;PYY;AVP;CRH;GRP;AGRP;NPPA;PNOC
protein bindingCOA6;NCKIPSD;BCL2A1A;USP2;DCSTAMP;CAND2;H3F3A;PRKCI;FAM128B
receptor bindingNPFFL;PKD2;ALCAM;GNPAT;NRG4;HAMP;CHRNA10;MSTN;GLA

CRH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRH here. Most of them are supplied by our site. Hope this information will be useful for your research of CRH.

CRHR1; KRT31

Liguori, G; Squillacioti, C; et al. Presence and Distribution of Urocortin and its Receptors in the Epididymis of Alpaca (Vicugna pacos). ANATOMIA HISTOLOGIA EMBRYOLOGIA 44:66-71(2015).
Topp, MS; Gokbuget, N; et al. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study. LANCET ONCOLOGY 16:57-66(2015).
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