CRH

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CRH

Official Full Name corticotropin releasing hormone
Background Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to;stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal;recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including;hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in;peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that;determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels;of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this;protein may act as a trigger for parturition.
Synonyms CRH; corticotropin releasing hormone; corticoliberin; corticotropin releasing factor; CRF; corticotropin-releasing factor
    • Species :
    • Bacillus subtilis
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli or Yeast
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CRH-107H Recombinant Human CRH, His-tagged E.coli His
    Human CRH-108H Recombinant Human CRH, GST-tagged Wheat Germ GST
    Human CRH-183H Recombinant Human CRH Mammalian Cell His
    Human CRH-217H Recombinant Human CRH protein, T7-tagged E.coli T7
    Human CRH-3048H Recombinant Human Corticotropin Releasing Hormone, T7-tagged E.coli T7
    Human CRH-7281HCL Recombinant Human CRH 293 Cell Lysate HEK293 N/A
    Human CRH-7791H Recombinant Human CRH protein, His & GST-tagged E.coli His/GST
    Mouse CRH-3901M Recombinant Mouse CRH Protein Mammalian Cell His
    Mouse Crh-7792M Recombinant Mouse Crh protein, His-tagged E.coli His
    Rat CRH-1596R Recombinant Rat CRH Protein Mammalian Cell His
    Rat Crh-7793R Recombinant Rat Crh protein, His-tagged E.coli His
    Rat Crh-7794R Recombinant Rat Crh protein, His & GST-tagged E.coli His/GST
    Chicken CRH-3836C Recombinant Chicken CRH Mammalian Cell His
    Bacillus subtilis CRH-0033B Recombinant Bacillus subtilis CRH protein, His-tagged E. coli or Yeast His

    CRH involved in several pathways and played different roles in them. We selected most pathways CRH participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alcoholism GM14479; HIST3H2BB-PS; GRIN3A; HIST1H2BQ; H2AFB3; HIST1H2AA; H2AFX; HIST2H2AC; SLC18A2; HIST2H2AA4
    Class B/2 (Secretin family receptors) GNB5A; PTHLH; RCA2.1; GNB5B; GHRH; PTH; ADM; PTH2; RAMP1; SCT
    Corticotropin-releasing hormone KRT1; IVL; TRIM28; KRT14; CYP21A2; JUNB; PARP1; CYP11A1; ADRBK2; JUND
    G alpha (s) signalling events NPSR1; NPS; CRH; RAMP1; ADRB3; ADM2A; ADCYAP1R1; PTHLHA; CALCA; RLN2
    GPCR downstream signaling ARHGEF18A; RGS1; MGLL; OPN1MW; OPN4A; PTHRP2; GPR4; EDNRA; DGKB; GPR65
    GPCR ligand binding SSTR3; CHRM4; CXCL11.8; LTB4R; S1PR3; KISS1; PRLH; CD97; CHRM5; MLN
    Long-term depression BRAF; GNAI2; NOS1; RYR1; PLA2G4A; GNA11; GRID2; GNA13; GNAZ; HRAS
    Myometrial Relaxation and Contraction Pathways CRH; IGFBP6; PKIG; RGS6; RAMP3; RGS14; CRCP; GABPA; RAMP2; CRHR1

    CRH has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by CRH itself. We selected most functions CRH had, and list some proteins which have the same functions with CRH. You can find most of the proteins on our site.

    Function Related Protein
    corticotropin-releasing hormone receptor 1 binding GNAO1A; CRH; UCN; GNAS; GNAO1; GNAO1B
    corticotropin-releasing hormone receptor 2 binding CRH; UCN; UCN2; UCN3; UCN3L
    hormone activity IAPP; INHBB; MLN; CALCA; RLN3; CCK; CRH; C19orf80; SST2; SST
    neuropeptide hormone activity NTS; ADCYAP1; PNOC; AVP; VIP; QRFP; GRP; TRH; NPFFL; AGRP
    protein binding CNTNAP4; EDEM1; ITGAL; CA1; AKT1S1; SIRT1; RAC3; CIAO1; RAB27A; UBE2D2
    receptor binding CXCL10; FGF13A; ENSA; EDN3; CHRNA10; LBP; SNX17; NPFFL; C1QTNF2; HAO1

    CRH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRH here. Most of them are supplied by our site. Hope this information will be useful for your research of CRH.

    CRHR1; KRT31

    Liguori, G; Squillacioti, C; et al. Presence and Distribution of Urocortin and its Receptors in the Epididymis of Alpaca (Vicugna pacos). ANATOMIA HISTOLOGIA EMBRYOLOGIA 44:66-71(2015).
    Topp, MS; Gokbuget, N; et al. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study. LANCET ONCOLOGY 16:57-66(2015).

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