crh
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  • Official Full Name
  • corticotropin releasing hormone
  • Background
  • Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to;stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal;recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including;hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in;peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that;determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels;of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this;protein may act as a trigger for parturition.
  • Synonyms
  • CRH; corticotropin releasing hormone; corticoliberin; corticotropin releasing factor; CRF; corticotropin-releasing factor
Cat.#:CRH-107HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRH, His-tagged
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Cat.#:CRH-108HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CRH, GST-tagged
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Cat.#:CRH-183HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human CRH
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Cat.#:CRH-217HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRH protein, T7-tagged
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Cat.#:CRH-7791HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CRH protein, His & GST-tagged
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Cat.#:CRH-3901MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CRH Protein
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Cat.#:Crh-7792MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Crh protein, His-tagged
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Cat.#:CRH-1596RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CRH Protein
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Cat.#:Crh-7793RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Crh protein, His-tagged
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Cat.#:Crh-7794RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Crh protein, His & GST-tagged
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Cat.#:CRH-3836CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CRH
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Cat.#:CRH-0033BTag:His
Source (Host):E. coli or YeastSpecies:Bacillus subtilis
Product nameRecombinant Bacillus subtilis CRH protein, His-tagged
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Cat.#:CRH-3048HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Corticotropin Releasing Hormone, T7-tagged
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Cat.#:CRH-7281HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CRH 293 Cell Lysate
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Involved Pathway

CRH involved in several pathways and played different roles in them. We selected most pathways CRH participated on our site, such as Alcoholism, Class B/2 (Secretin family receptors), Corticotropin-releasing hormone, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alcoholism
H2AFB3; HIST1H2BN; HIST2H2BE; SOS1; GNG11; HIST1H4G; HIST1H2BC; HIST1H4J; SLC29A1; HIST1H4D
Class B/2 (Secretin family receptors)
RCA2.1; GNB5B; CRHR1; ADCYAP1B; SETD6; PTHLHA; EMR2; ADM2A; ADM2; GNB3B
Corticotropin-releasing hormone
KRT14; JUNB; KRT1; CASP12; CYP11B1; CYP11A1; CYP21A2; TFAP2A; CRHBP; CRHR2
G alpha (s) signalling events
RXFP2B; RLN3A; GCGB; CRHR1; VIP2; ADCYAP1; ADCYAP1B; CALCB; ADRB3; PTHLH
GPCR downstream signaling
ECT2; NPFF; TAS2R13; NMUR1; CALCB; CASR; OR10A5; GNA13; SOUL4; OPN1MW2
GPCR ligand binding
PTGDR2; PTHLHA; OXGR1A.1; GPR55; GCGA; TAS2R13; GPRC6A; NPSR1; CX3CR1; EMR2
Long-term depression
GNAI1; PLA2G4D; GNA12; PLA2G4A; PPP2R1B; ARAF; PRKCA; PRKG1; LYN; GNAO1
Myometrial Relaxation and Contraction Pathways
RGS4; RGS17; RAMP2; RAMP3; IGFBP5; ADM; CNN2; CORIN; CRH; PKIG

Protein Function

CRH has several biochemical functions, for example, corticotropin-releasing hormone receptor 1 binding, corticotropin-releasing hormone receptor 2 binding, hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CRH itself. We selected most functions CRH had, and list some proteins which have the same functions with CRH. You can find most of the proteins on our site.
Function
Related Protein
Function corticotropin-releasing hormone receptor 1 binding
Related Protein GNAS; CRH; GNAO1A; GNAO1B; UCN; GNAO1
Function corticotropin-releasing hormone receptor 2 binding
Related Protein UCN2; UCN3; UCN3L; UCN; CRH
Function hormone activity
Related Protein CRHR2; URP2; C19orf80; INHBAB; NMB; TTR; APLN; LHB; ADCYAP1B; EPO
Function neuropeptide hormone activity
Related Protein PRLH; QRFP; AGRP; CORT; NPFF; GAL; POMCA; AVP; NTS; UCN
Function protein binding
Related Protein TMEM106B; SIPA1L2; AKAP8L; CRYBA4; FAF1; STX11; RBM41; RAP1A; KDM5B; PSRC1
Function receptor binding
Related Protein F2R; CD86; PVRL4; HRG; ADM; RIPK2; GFRA1; FGF11A; GIPC1; PEX14

Interacting Protein

CRH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRH here. Most of them are supplied by our site. Hope this information will be useful for your research of CRH.
CRHR1; KRT31

CRH Related Articles

Liguori, G; Squillacioti, C; et al. Presence and Distribution of Urocortin and its Receptors in the Epididymis of Alpaca (Vicugna pacos). ANATOMIA HISTOLOGIA EMBRYOLOGIA 44:66-71(2015).
Topp, MS; Gokbuget, N; et al. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study. LANCET ONCOLOGY 16:57-66(2015).