Recombinant Full Length Human CRH Protein, GST tagged

Cat.No. : CRH-107H
Product Overview : Human CRH full-length ORF ( NP_000747.1, 1-196 aa) recombinant protein with GST-tag at N-terminal was expressed in vitro.
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Species : Human
Source : In Vitro Cell Free System
Tag : GST
Protein Length : 1-196 aa
Description : Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from a 191-amino acid preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin dificiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition.
Molecular Mass : 47.8 kDa
AA Sequence : MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLLLPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
Application : Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array
Quality Control Testing : 12.5% SDS-PAGE Stained with Coomassie Blue.
Note : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH8.0 in the elution buffer.
Gene Name CRH corticotropin releasing hormone [ Homo sapiens (human) ]
Official Symbol CRH
Synonyms CRH; corticotropin releasing hormone; corticoliberin; corticotropin releasing factor; CRF; corticotropin-releasing factor;
Gene ID 1392
mRNA Refseq NM_000756
Protein Refseq NP_000747
MIM 122560
UniProt ID P06850

Not For Human Consumption!

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