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GPR50

Official Full Name

G protein-coupled receptor 50
Overview

This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women.
Synonyms

GPR50; G protein-coupled receptor 50; melatonin-related receptor; H9; Mel1c; G protein coupled receptor 50; GPR 50; MGC125342; MTNRL;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads
Assay Kits

Species

Chicken
Homo sapiens (Human)
Human
Mouse
Mus musculus (Mouse)
Ovis aries (Sheep)

Source

E.coli
E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GPR50-13478H	Recombinant Human GPR50, GST-tagged	E.coli	GST	C-term-323a.a.	$319 / 25ug
Human	GPR50-746HCL	Recombinant Human GPR50 cell lysate		N/A		Inquiry
Human	GPR50-5249H	Recombinant Human GPR50 Protein	Wheat Germ	N/A		Inquiry
Human	GPR50-5250H	Recombinant Human GPR50 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GPR50-5595HF	Recombinant Full Length Human GPR50 Protein	In Vitro Cell Free System		572 amino acids	Inquiry
Human	GPR50-5597HF	Recombinant Full Length Human GPR50 Protein, GST-tagged	In Vitro Cell Free System	GST	617 amino acids	Inquiry
Mouse	GPR50-7191M	Recombinant Mouse GPR50 Protein	Mammalian Cell	His		Inquiry
Mouse	GPR50-3881M	Recombinant Mouse GPR50 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	GPR50-3881M-B	Recombinant Mouse GPR50 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL30550HF	Recombinant Full Length Human Melatonin-Related Receptor(Gpr50) Protein, His-Tagged	E.coli expression system	His	Full Length (1-617)	Inquiry
Mus musculus (Mouse)	RFL6637MF	Recombinant Full Length Mouse Melatonin-Related Receptor(Gpr50) Protein, His-Tagged	E.coli expression system	His	Full Length (1-583)	Inquiry
Ovis aries (Sheep)	RFL23569OF	Recombinant Full Length Sheep Melatonin-Related Receptor(Gpr50) Protein, His-Tagged	E.coli expression system	His	Full Length (1-575)	Inquiry
Chicken	GPR50-6913C	Recombinant Chicken GPR50	Mammalian Cell	His		Inquiry
Chicken	GPR50-1144C	Recombinant Chicken GPR50 Protein, His&GST-tagged	E.coli	N-His&GST	Gly293-Leu346	Inquiry
	Kit-1318	GPR50 CHO-K1 β-Arrestin Orphan GPCR Assay Kit		N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein
GPR50 Related Research Area

GPR50 involved in several pathways and played different roles in them. We selected most pathways GPR50 participated on our site, such as GPCRs, Class A Rhodopsin-like, Neuroactive ligand-receptor interaction, Small Ligand GPCRs, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPR50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
GPCRs, Class A Rhodopsin-like	GPR85;SSTR2;CCBP2;CYSLTR1;CNR2;ACKR4;GPR75;DRD4;ADORA3
Neuroactive ligand-receptor interaction	GABRB2;GZMA;TAAR14B;TAAR13B;PRSS3;TAAR14H;GLRB;CHRNA2;GRM3
Small Ligand GPCRs

GPR50 has several biochemical functions, for example, G-protein coupled receptor activity, identical protein binding, melatonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPR50 itself. We selected most functions GPR50 had, and list some proteins which have the same functions with GPR50. You can find most of the proteins on our site.

Function	Related Protein
G-protein coupled receptor activity	COR1;BAI3;C3AR1;OR8A1;GPR114;OLFR10;GRM6B;TAS2R116;OPN1MW3
identical protein binding	CLDN2;IGF2R;SIAH1;SMAD4;SEPT7;PHYKPL;PLEKHH2;CUBN;KDM6A
melatonin receptor activity	MTNR1AA;MTNR1A;GPR50;MTNR1AL;MTNR1BB;MTNR1BA;MTNR1B;MTNR1C
protein binding	RD3;PHB;HS3ST5;HAPLN2;CCL28;PPIL3;FAM86C;ZFP36L1;HSPA4

GPR50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPR50 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPR50.

MT1A; ZNF572; MT2A; GNAI1

Nogo Proteins and Receptors