hadh
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  • Official Full Name
  • hydroxyacyl-CoA dehydrogenase
  • Background
  • This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15.
  • Synonyms
  • HADH; hydroxyacyl-CoA dehydrogenase; HADHSC, hydroxyacyl Coenzyme A dehydrogenase , L 3 hydroxyacyl Coenzyme A dehydrogenase, short chain; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HADH1; SCHAD; short-chain 3-hydroxyacyl-CoA dehydrogenase; L-
Cat.#:HADH-4557HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HADH Protein, GST-tagged
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Cat.#:HADH-1694HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Hydroxyacyl-Coenzyme A Dehydrogenase, His-tagged
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Cat.#:HADH-2032HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HADH, His-tagged
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Cat.#:HADH-27760THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HADH
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Cat.#:HADH-845HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Hydroxyacyl-CoA Dehydrogenase, T7-tagged
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Cat.#:HADH-7468MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HADH Protein
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Cat.#:Hadh-8167MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hadh protein, His & T7-tagged
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Cat.#:HADH-2781RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HADH Protein
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Cat.#:HADH-2032RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey HADH Protein, His-tagged
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Cat.#:HADH-5234CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HADH
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Cat.#:HADH-956ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HADH
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Cat.#:HADH-5646HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human HADH 293 Cell Lysate
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Involved Pathway

HADH involved in several pathways and played different roles in them. We selected most pathways HADH participated on our site, such as Fatty acid elongation, Fatty acid degradation, Valine, leucine and isoleucine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HADH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Fatty acid elongation
TECR; HSD17B12B; ELOVL1; HADHA; ACOT5; TECRB; HSD17B12; ELOVL5; ELOVL4A; ELOVL2
Fatty acid degradation
ACAA1A; ALDH9A1; ADH7; CPT1A; ACADSB; ACADL; ACADS; GCDH; ACSL5; ALDH2
Valine, leucine and isoleucine degradation
MCCC1; AACS; OXCT1A; HMGCS2; PCCA; DLDH; ALDH9A1B; BCAT2; ALDH9A1; IVD
Lysine degradation
EHMT1B; ALDH1B1; HADHA; KMT2E; AADAT; SETD1BA; OGDHL; SETD1B; EHMT2; ACAT2
Tryptophan metabolism
GCDHB; AOC1; ALDH1B1; IL4I1; TPH1A; GCDHA; ALDH2; CMTM2A; ABP1; CYP2F1
Butanoate metabolism
EHHADH; GAD1B; GAD2; HMGCS1; HADHAB; HMGCL; ACSM5; OXCT1A; HADHA; GAD1
Metabolic pathways
GFPT1; GRHPRA; B4GALT4; BCAT2; PMM1; QDPRA; NTPCR; DNMT3AB; AGPAT4; UGT1A1
Fatty acid metabolism
ACSL5; ACSL4; ACAA1; TECRB; ACAA1A; SCD; SCD5; HADHAA; FADS2; ACADL

Protein Function

HADH has several biochemical functions, for example, 3-hydroxyacyl-CoA dehydrogenase activity, NAD+ binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HADH itself. We selected most functions HADH had, and list some proteins which have the same functions with HADH. You can find most of the proteins on our site.
Function
Related Protein
Function 3-hydroxyacyl-CoA dehydrogenase activity
Related Protein HADHAA; HSD17B8; HADHB; H2-KE6; HADHA; HADHAB; HSD17B4; EHHADH; HSD17B10; HADH
Function NAD+ binding
Related Protein SIRT2; SIRT3; SIRT6; SIRT1; HPGD; SIRT4; ALDH1A3; GLUD1; SIRT5; SIRT7

Interacting Protein

HADH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HADH here. Most of them are supplied by our site. Hope this information will be useful for your research of HADH.
UBA5; ADH1A; STAT1; 2_aha_camp; 8-aha-camp; 8-aha-omethyladenosine