HGFAC
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Official Full Name
HGF Activator
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Overview
The protein encoded by this gene belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. -
Synonyms
HGFAC; HGF activator; HGFA; MGC138395; MGC138397; EC 3.4.21.; Hepatocyte growth factor activator; Hepatocyte growth factor activator short chain; Hepatocyte growth factor activator long chain;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Human Cell
- Mammalian Cell
- His
- His|GST
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HGFAC-488H | Recombinant Human HGFAC, His tagged | HEK293 | His | Met 1-Ser 655 | |
Human | HGFA-2940HCL | Recombinant Human HGFA cell lysate | Human Cell | N/A | ||
Human | HGFAC-2237H | Recombinant Human HGFAC Protein, His-tagged | E.coli | N-His | Asn340-Gln595 | |
Mouse | Hgfac-1594M | Recombinant Mouse Hgfac protein, His & GST-tagged | E.coli | His/GST | Pro104~Asp351 (Accession # Q9R098) | |
Rat | Hgfac-1595R | Recombinant Rat Hgfac protein, His & GST-tagged | E.coli | His/GST | Ala363~Arg622 (Accession # Q5EBA7) | |
Zebrafish | HGFA-2081Z | Recombinant Zebrafish HGFA | Mammalian Cell | His |
- Q&As
- Reviews
Q&As (7)
Ask a questionThere are currently no approved drugs specifically targeting HGFAC that are widely available. However, several new drugs targeting HGFAC are under early-stage research and clinical trials. These drugs aim to inhibit the biological activity of HGFAC or restore it to normal levels for the treatment of various diseases.
HGFAC, as a biomarker, can be applied in the diagnosis and therapeutic monitoring of many diseases. For example, HGFAC levels can serve as a tumor marker in the diagnosis and assessment of treatment efficacy in diseases such as liver cancer, pancreatic cancer, and colorectal cancer. Furthermore, in diseases like kidney disease and primary sclerosing cholangitis, HGFAC levels are considered biomarkers of diagnostic and therapeutic monitoring significance.
HGFAC functions as a protease and its activation of HGF involves proteolytic cleavage and binding between different domains of HGF. The proteolytic action of HGFAC induces structural changes in the HGF molecule, leading to its interaction with the c-Met receptor and subsequent activation of downstream signaling pathways.
The activation and inhibition of HGFAC can have different effects on human health. In terms of tissue repair and regeneration, HGFAC activation is crucial for the proper functioning of the HGF signaling pathway, making it important for the treatment of tissue injuries and diseases. However, dysregulated HGFAC activation has pathological implications in diseases like cancer and fibrosis. Inhibiting HGFAC may have potential therapeutic effects, suppressing disease progression and alleviating symptoms.
HGFAC, also known as Hepatocyte Growth Factor Activator, plays a crucial role in the activation of hepatocyte growth factor (HGF). Its dysregulation has been implicated in various diseases such as cancer, liver disease, and kidney disease. In liver and pancreatic cancer, HGFAC promotes tumor proliferation and angiogenesis. Excessive activation of HGFAC can also lead to hepatocyte apoptosis and liver fibrosis. Additionally, elevated plasma levels of HGFAC have been associated with hypertension, stroke, glucose instability, and metabolic syndrome.
Dysregulation of HGFAC has been associated with various diseases and pathological conditions. For example, overexpression of HGFAC has been linked to the progression of certain cancers, as it can enhance cell proliferation, migration, and invasiveness. On the other hand, decreased expression or mutations in HGFAC have been associated with impaired tissue regeneration and wound healing. Understanding the dysregulation of HGFAC may contribute to the development of targeted therapies for these diseases.
Recent research advances have highlighted HGFAC as a potential target for treating various diseases. Drugs targeting the HGF/c-Met signaling pathway have garnered significant interest, with some targeted therapies entering clinical research. However, the development of drugs targeting HGFAC still faces challenges such as lack of specificity and efficacy, as well as the need for a better understanding of long-term safety profiles.
Customer Reviews (3)
Write a reviewUnlocking new possibilities, the innovation surrounding this experimental reagent surpasses previous research limitations.
Harnessing impeccable formulations, it epitomizes perfection in experimental outcomes.
The reagent of choice for enhancing reliability in experimentation.
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