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Recombinant Mouse Hgfac protein, His & GST-tagged

Cat.No. : Hgfac-1594M
Product Overview : Recombinant Mouse Hgfac aa. (Pro104~Asp351 (Accession # Q9R098)) fused with N-terminal His & GST tag was produced in E. coli cells.
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  • Gene Information
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Description : This gene encodes a serine protease enzyme that proteolytically activates hepatocyte growth factor (HGF) and plays a vital role in the regulation of HGF activity in the regeneration and repair of various tissues. The encoded protein is an inactive zymogen that is proteolytically activated to generate a heterodimeric enzyme consisting of a short chain and a long chain linked by a disulfide bridge. Mice lacking the encoded protein display an impairment in mucosal regeneration after injury.
Source : E. coli
Species : Mouse
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 53.7kDa
Protein length : Pro104~Asp351 (Accession # Q9R098)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Isoelectric Point : 6.1
Gene Name : Hgfac hepatocyte growth factor activator [ Mus musculus (house mouse) ]
Official Symbol : Hgfac
Synonyms : Hgfac; hepatocyte growth factor activator; HGFA; hepatocyte growth factor activator; HGF activator
Gene ID : 54426
mRNA Refseq : NM_019447.3
Protein Refseq : NP_062320.2
UniProt ID : Q9R098

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there currently any drugs targeting HGFAC? 02/01/2023

There are currently no approved drugs specifically targeting HGFAC that are widely available. However, several new drugs targeting HGFAC are under early-stage research and clinical trials. These drugs aim to inhibit the biological activity of HGFAC or restore it to normal levels for the treatment of various diseases.

which areas can HGFAC serve as a biomarker? 10/14/2022

HGFAC, as a biomarker, can be applied in the diagnosis and therapeutic monitoring of many diseases. For example, HGFAC levels can serve as a tumor marker in the diagnosis and assessment of treatment efficacy in diseases such as liver cancer, pancreatic cancer, and colorectal cancer. Furthermore, in diseases like kidney disease and primary sclerosing cholangitis, HGFAC levels are considered biomarkers of diagnostic and therapeutic monitoring significance.

How is the molecular mechanism underlying the activation of HGFAC elucidated? 09/11/2022

HGFAC functions as a protease and its activation of HGF involves proteolytic cleavage and binding between different domains of HGF. The proteolytic action of HGFAC induces structural changes in the HGF molecule, leading to its interaction with the c-Met receptor and subsequent activation of downstream signaling pathways.

How does the activation and inhibition of HGFAC affect human health? 02/04/2022

The activation and inhibition of HGFAC can have different effects on human health. In terms of tissue repair and regeneration, HGFAC activation is crucial for the proper functioning of the HGF signaling pathway, making it important for the treatment of tissue injuries and diseases. However, dysregulated HGFAC activation has pathological implications in diseases like cancer and fibrosis. Inhibiting HGFAC may have potential therapeutic effects, suppressing disease progression and alleviating symptoms.

How can HGFAC be defined and what role does it play in the pathology of human diseases? 10/22/2019

HGFAC, also known as Hepatocyte Growth Factor Activator, plays a crucial role in the activation of hepatocyte growth factor (HGF). Its dysregulation has been implicated in various diseases such as cancer, liver disease, and kidney disease. In liver and pancreatic cancer, HGFAC promotes tumor proliferation and angiogenesis. Excessive activation of HGFAC can also lead to hepatocyte apoptosis and liver fibrosis. Additionally, elevated plasma levels of HGFAC have been associated with hypertension, stroke, glucose instability, and metabolic syndrome.

Are there any clinical implications of HGFAC dysregulation? 06/04/2018

Dysregulation of HGFAC has been associated with various diseases and pathological conditions. For example, overexpression of HGFAC has been linked to the progression of certain cancers, as it can enhance cell proliferation, migration, and invasiveness. On the other hand, decreased expression or mutations in HGFAC have been associated with impaired tissue regeneration and wound healing. Understanding the dysregulation of HGFAC may contribute to the development of targeted therapies for these diseases.

What are the advancements made thus far in the realm of targeted therapies and drug discovery specifically pertaining to HGFAC? 05/24/2018

Recent research advances have highlighted HGFAC as a potential target for treating various diseases. Drugs targeting the HGF/c-Met signaling pathway have garnered significant interest, with some targeted therapies entering clinical research. However, the development of drugs targeting HGFAC still faces challenges such as lack of specificity and efficacy, as well as the need for a better understanding of long-term safety profiles.

Customer Reviews (3)

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Reviews
06/02/2022

    Unlocking new possibilities, the innovation surrounding this experimental reagent surpasses previous research limitations.

    05/31/2020

      Harnessing impeccable formulations, it epitomizes perfection in experimental outcomes.

      04/06/2020

        The reagent of choice for enhancing reliability in experimentation.

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