ifne
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  • Official Full Name
  • interferon, epsilon
  • Background
  • Tau, a microtubulebinding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by glycogen synthase kinase 3 (GSK 3). Cellular and subcellular localization: In situ, anti-tau-1 has a stringent specificity for the axons of neurons. The antibody does not stain the cell bodies or dendrites of neurons, nor does it stain any other cell type (4). However, this in vivo intracellular specificity is not maintained in culture: anti-tau-1 stains the axon, cell bodies, and dendrites of rat hippocampal neurons grown in culture (5). The specificity of anti-tau-1 was originally thought to represent the restricted expression of tau to axons. Later studies revealed that this specificity is dependant on the state of phosphorylation. In dephosphorylated samples (samples treated with alkaline phosphatase) anti-tau-1 stains astrocytes, perineuronal glial cells, and the axons, cell bodies and dendrites of neurons, while in untreated samples, anti-tau-1 stains only axons (6). (The epitope recognized by anti-tau-1 is probably at or near a phosphorylated site.)
  • Synonyms
  • IFNE; interferon, epsilon; interferon epsilon; IFNE1; IFN-epsilon; interferon tau-1; interferon-epsilon; interferon epsilon 1; interferon epsilon-1; IFN-E; IFNT1; PRO655; MGC119018; MGC119020
Cat.#:IFNE-1057MTag:His-SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse IFNE Protein (22-192 aa), His-SUMO-tagged
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Cat.#:IFNE-1688MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse IFNE Protein (22-192 aa), His-tagged
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Cat.#:IFNE-52HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNE protein, His/T7-tagged
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Cat.#:IFNE-53HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IFNE protein, GST-tagged
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Cat.#:IFNE-54HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IFNE protein, GST-tagged
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Cat.#:IFNE-8040MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IFNE Protein
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Cat.#:IFNE-5278HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IFNE 293 Cell Lysate
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Involved Pathway

IFNE involved in several pathways and played different roles in them. We selected most pathways IFNE participated on our site, such as Cytokine-cytokine receptor interaction, RIG-I-like receptor signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL2RGA; CCL19; FLT1; BMPR2B; IL13RA1; ACVR2A; XCL1; Cxcl15; IL2RGB; CD27
RIG-I-like receptor signaling pathway
NFKBIB; MAPK12B; IKBKB; ATG5; NT5C3; ISG15; TRAF6; SIKE1; IFNA14; TRADD
Jak-STAT signaling pathway
LEPR; AOX4; IL13; IL24; IFNGR2; IL10RA; Ifnlr1; IL21R; CISHB; SOCS1A

Protein Function

IFNE has several biochemical functions, for example, cytokine activity, type I interferon receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNE itself. We selected most functions IFNE had, and list some proteins which have the same functions with IFNE. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein GDF7; CSF1A; FLT3LG; BMP7A; IL17F; CD70; IL10; Flt3l; ILTIFB; IFNK
Function type I interferon receptor binding
Related Protein IFNA1; IFNA14; IFNA4; RNF207B; Ifna15; GM13287; IFNA7; IFNA2; IFNA16; IFNA17

IFNE Related Articles

Guo, YL; Gao, MC; et al. Molecular cloning and characterization of a novel bovine IFN-epsilon. GENE 558:25-30(2015).
Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).

IFNE Related Gene Family

Cytokines