• Official Full Name
  • insulin-like growth factor 2 mRNA binding protein 3
  • Background
  • Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor. The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded prot
  • Synonyms
  • IGF2BP3; insulin-like growth factor 2 mRNA binding protein 3; insulin-like growth factor 2 mRNA-binding protein 3; cancer/testis antigen 98; CT98; IGF II mRNA binding protein 3; IMP 3; hKOC; VICKZ family member 3; IGF2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; KH domain containing protein overexpressed in cancer; KH domain-containing protein overexpressed in cancer; IMP3; KOC1; IMP-3; VICKZ3; DKFZp686F1078; OTTHUMP00000158561; VICKZ3.
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IGF2BP3 Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2BP3, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2BP3 protein, His/T7-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGF2BP3 protein, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IGF2BP3 Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IGF2BP3
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IGF2BP3

Involved Pathway

IGF2BP3 involved in several pathways and played different roles in them. We selected most pathways IGF2BP3 participated on our site, such as Gene Expression, Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2BP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
ZNF582; ZNF460; TSEN15; COX7C; ZNF584; ZNF548; ZNF529; CHST13; RPP40; THG1L
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Protein Function

IGF2BP3 has several biochemical functions, for example, RNA binding, mRNA 3-UTR binding, mRNA 5-UTR binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2BP3 itself. We selected most functions IGF2BP3 had, and list some proteins which have the same functions with IGF2BP3. You can find most of the proteins on our site.
Related Protein
Function RNA binding
Related Protein HNRNPF; RCAN3; Akap17b; CELF3A; PCBP3; RPL9; THOC3; SMN2; HNRNPUL1; SMN1
Function mRNA 3-UTR binding
Related Protein ELAVL1; FXR1; PARN; RNF20; ZNF385A; CRYZ; RBM38; IGF2BP1; CIRBP; PUM1
Function mRNA 5-UTR binding
Related Protein RPS14; MRPS11; IGF2BP3; IGF2BP1; IGF2BP2; LARP1; DDX3X
Function nucleotide binding
Function poly(A) RNA binding
Related Protein HIST1H4M; SUGP2; SURF6; ZNF326; RBM8A; EIF4B; ZC3H18; ZFP346; MRPL21; DEK
Function protein binding
Related Protein SLC35F6; LONP1; POLR2E; ZNF193; NPAS2; SEMA7A; SFTPD; KPNA1; FCN2; TMEM67
Function translation regulator activity
Related Protein IGF2BP3; YBX2; RPS14; IGF2BP2; AIRE; RPS9; IGF2BP1

Interacting Protein

IGF2BP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2BP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2BP3.
CNBP; Ybx1; POLR1E; PUF60; midostaurin; ssrna_ug