IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of neural development (Bellefroid et al., 1998 [PubMed 9427753]). Members of this family appear to play multiple roles during pattern formation of vertebrate embryos (Lewis et al., 1999 [PubMed 10370142]).[supplied by OMIM, Aug 2009]
IRX3; iroquois homeobox 3; IRX-1; IRXB1; iroquois-class homeodomain protein IRX-3; homeodomain protein IRXB1; iroquois homeobox protein 3; iroquois-class homeodomain protein IRX-1;
IRX3 has several biochemical functions, for example, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRX3 itself. We selected most functions IRX3 had, and list some proteins which have the same functions with IRX3. You can find most of the proteins on our site.
Function sequence-specific DNA binding
Related Protein SOX21B; CUX1; ENG2A; HOXC5; POU3F3A; CREB3L1; FOXN2; DMBX1; FOXM1; HOXB1B
IRX3 Related Articles
Juraver-Geslin, HA; Gomez-Skarmeta, JL; et al. The conserved barH-like homeobox-2 gene barhl2 acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog. DEVELOPMENTAL BIOLOGY 396:107-120(2014).
Sato, T; Kobayashi, T; et al. Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 306:H1054-H1065(2014).