itgb3
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  • Official Full Name
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • Background
  • The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
  • Synonyms
  • GT; CD61; GP3A; BDPLT2; GPIIIa; integrin beta-3; platelet glycoprotein IIIa; platelet membrane glycoprotein IIIa; CD41; CD41b; GP 2B; GP IIb; GTA; HPA3; Integrin alpha 2b; ITGA2B; ITGB3; Tadocizumab; 339086-80-5
Cat.#:ITGAV & ITGB3-738HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGAV & ITGB3 Protein, His-Avi-tagged, Biotinylated
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Cat.#:ITGAV&ITGB3-739HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGAV/ITGB3 protein, His-tagged
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Cat.#:ITGB3-12HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGB3 protein, MYC/DDK-tagged
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Cat.#:ITGB3-16HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGB3 protein, His/S-tagged
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Cat.#:ITGB3-6740HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGB3 protein, His-tagged
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Cat.#:Itgb3-6741MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itgb3 protein, His & S-tagged
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Cat.#:ITGB3-8366MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITGB3 Protein
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Cat.#:ITGB3-5888CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ITGB3
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Cat.#:ITGB3-11HTag:N/A
Source (Host):Species:Human
Product nameNative Human GPIIbIIIa
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Cat.#:ITGB3-5124HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITGB3 293 Cell Lysate
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Involved Pathway

ITGB3 involved in several pathways and played different roles in them. We selected most pathways ITGB3 participated on our site, such as Rap signaling pathway, Phagosome, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rap signaling pathway
RAC1; F2RL3; RAPGEF6; ITGB1; FGF21; PDGFRA; RAPGEF5; F2R; HRAS; VEGFC
Phagosome
MHC2DAB; RAB7B; RAB5C; LAMP1; HLA-C; FCAR; CORO1A; DYNC1LI2; CD209A; ATP6V1E2
PIK-Akt signaling pathway
PPP2R3A; IFNAR1; IFNA21; CCND3; FGFR2; EIF4E2; PKN1; TLR4; RAC1; FN1
Osteoclast differentiation
cgr2b; ACP5; IFNB1; FCGR1A; IKBKB; LILRA4; RELB; TRAF2; MITF; TYROBP
Focal adhesion
PIP5K1C; PGF; ITGA6; PXN; LAMB1A; PRKCB; PPP1CB; TLN1; ACTN2; LAMA4
ECM-receptor interaction
THBS3; LAMC3; ITGB1; COL5A2; COL27A1A; LAMB2; LAMC2; COL4A3; CHAD; ITGA6B
Platelet activation
MYLK4; PPP1CA; PIK3CG; SYK; FCER1G; PIK3CB; FCGR2A; PLCB2; BTK; RAP1A
Hematopoietic cell lineage
Cd24a; CD3E; GM2002; CSF3; FLT3LG; Il6ra; CD37; CD44; CD8A; CD3G
Regulation of actin cytoskeleton
HRAS; GNG12; FN1; WASLB; GSNA; ARPC5A; INSB; ACTN2; WASB; FGFR3
Thyroid hormone signaling pathway
AKT1; TP53; PRKACB; PLCB4; DIO3; MDM2; RXRG; ITGB3; NOTCH4; ACTB
Proteoglycans in cancer
ITPR1; CTTN; IGF2; CAMK2B; ESR1; MAPK12; PPP1CC; STAT3; IGF1; ERBB2
MicroRNAs in cancer
FSCN1; CD44; NRAS; GLS; TP63; ATM; MARCKS; MAP2K1; EFNA3; SOCS1
Hypertrophic cardiomyopathy (HCM)
ITGA10; ITGB5; MYL3; ITGB3; EMD; CACNG4; SGCD; ITGA5; DMD; CACNA2D3
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ITGB1; ITGB7; ATP2A2; CTNNA2; JUP; SGCG; ACTN1; DSP; SGCA; DES
Dilated cardiomyopathy
TGFB3; Itga10&Itgb1; TGFB1; CACNA2D4; ITGA1; CACNG4; CACNB1; TNNC1; SGCA; MYL2

Protein Function

ITGB3 has several biochemical functions, for example, cell adhesion molecule binding, enzyme binding, extracellular matrix binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB3 itself. We selected most functions ITGB3 had, and list some proteins which have the same functions with ITGB3. You can find most of the proteins on our site.
Function
Related Protein
Function cell adhesion molecule binding
Related Protein NRXN1; PVRL1B; NRXN2; POSTN; ITGB1; PVR; CADM1B; SDCBP; NCR3; PVRL1
Function enzyme binding
Related Protein HIST1H2AN; CTNNB1; CYP1A1; ATP2A2; SIRT3; PEBP1; SELS; CYP2A4; ARRB2; HSPA8
Function extracellular matrix binding
Related Protein BGN; SID4; ITGB3; CD248; CYR61; GPR56; VTN; DCN; TGFBI; SPARC
Function fibronectin binding
Related Protein SFRP2; MFAP2; CTSK; ITGB3; IGFBP5B; IGFBP3; ITGA4; CCDC80; IGFBP5A; IGFBP5
Function identical protein binding
Related Protein CAV1; SIAH1; CLDN6; AIM2; FAS; SP100; SORD; REG3B; COMMD1; BIRC5
Function platelet-derived growth factor receptor binding
Related Protein PDGFAB; PDGFRB; FIGF; TYMP; LYN; PDGFA; PTEN; PDGFC; IL1R1; PDGFRA
Function protease binding
Related Protein DVL3; TRP53; FLOT2; ECM1; TYSND1; XBP1; ITGA3; FADD; TIMP2B; SERPINA1A
Function protein binding
Related Protein SLC25A5; RHOG; MC3R; EIF4A3; CHCHD3; MS4A1; ARHGEF3; URI1; PHYH; TOP3A
Function protein disulfide isomerase activity
Related Protein PDIA4; P4HB; TXNDC11; PDIA6; PIGK; TXNDC5; ITGB3; PDIA2; ERP44; GLRX2
Function vascular endothelial growth factor receptor 2 binding
Related Protein PDCL3; ITGB3; ITGA5; GREM1; VEGFA
Function virus receptor activity
Related Protein ITGB5; CD4; ITGA2; SELPLG; CD86; SERPINB3; PVR; ANPEP; CLEC5A; PVRL1

Interacting Protein

ITGB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB3.
ITGAV; ITGA2B

ITGB3 Related Articles

Regassa, A; Kim, WK; et al. Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol. BMC GENOMICS 16:-(2015).
Jin, Y; Wang, LM; et al. Differential expression of 5-HT-related genes in symptomatic pulmonary embolism patients. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 8:512-518(2015).