kcne2
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  • Official Full Name
  • potassium voltage-gated channel, Isk-related family, member 2
  • Background
  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
  • Synonyms
  • KCNE2; potassium voltage-gated channel, Isk-related family, member 2; LQT5; LQT6; ATFB4; MIRP1; potassium voltage-gated channel subfamily E member 2; minK-related peptide 1; minK-related peptide-1; potassium channel subunit, MiRP1; potassium channel subunit beta MiRP1; voltage-gated K+ channel subunit MIRP1; minimum potassium ion channel-related peptide 1; cardiac voltage-gated potassium channel accessory subunit 2;
Cat.#:KCNE2-240HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KCNE2, His-tagged
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Cat.#:KCNE2-8492MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KCNE2 Protein
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Cat.#:KCNE2-3178RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KCNE2 Protein
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Cat.#:KCNE2-5065HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KCNE2 293 Cell Lysate
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Involved Pathway

KCNE2 involved in several pathways and played different roles in them. We selected most pathways KCNE2 participated on our site, such as Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNE2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gastric acid secretion
ITPR1; CALM3; HRH2; KCNK10; KCNJ2; MYLK2; KCNJ16; Adcy4; CA2; GNAI1

Protein Function

KCNE2 has several biochemical functions, for example, contributes_to delayed rectifier potassium channel activity, contributes_to inward rectifier potassium channel activity, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNE2 itself. We selected most functions KCNE2 had, and list some proteins which have the same functions with KCNE2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to delayed rectifier potassium channel activity
Related Protein KCNE1; KCNQ1; KCNE2
Function contributes_to inward rectifier potassium channel activity
Related Protein KCNJ5; KCNJ3; KCNE2
Function ion channel binding
Related Protein AP2M1; S100A10; CALM2; GPD1L; BAK1; RYR2; SCN3B; PACS2; SLC8A1; VDAC1
Function potassium channel regulator activity
Related Protein KCNE3; DPP6; AKAP9; ANK2; KCNMB3; SGK3; AMIGO1; KCNE2; SGK1; KCNMB4
Function protein binding
Related Protein OSGIN1; ROPN1B; PIAS1; DST; AGO3; NABP1; NRSN1; DNAJB11; FMNL1; UBE2L6
Function protein homodimerization activity
Related Protein SLC4A1; CHMP4B; EXT1; OXCT1; NKX2; GPD1L; TREX2; DAPK3; TESC; SLK
Function voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Related Protein KCNH2; KCNE2; KCNQ1

KCNE2 Related Articles

Kinoshita, K; Yamaguchi, Y; et al. A Novel Missense Mutation Causing a G487R Substitution in the S2-S3 Loop of Human ether-a-go-go-Related Gene Channel. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 23:1246-1253(2012).
Zhang, M; Wang, YH; et al. KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 302:H910-H922(2012).