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KPNA2

  • Official Full Name

    karyopherin alpha 2 (RAG cohort 1, importin alpha 1)

  • Overview

    The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008]
  • Synonyms

    KPNA2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); QIP2; RCH1; IPOA1; SRP1alpha; importin subunit alpha-1; pendulin; SRP1-alpha; RAG cohort 1; importin alpha 1; importin alpha 2; importin-alpha-P1; RAG cohort protein 1; importin subunit alpha-2; karyopherin subunit alpha-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KPNA2-29809TH Recombinant Human KPNA2, T7 -tagged E.coli T7
Human KPNA2-1389H Recombinant Human Karyopherin Alpha 2 (RAG cohort 1, importin alpha 1), His-tagged E.coli His
Human KPNA2-1049H Recombinant Human KPNA2, His-tagged E.coli His
Human KPNA2-2900H Recombinant Human KPNA2, T7-tagged E.coli T7
Human KPNA2-4891HCL Recombinant Human KPNA2 293 Cell Lysate HEK293 N/A
Human KPNA2-969HFL Recombinant Full Length Human KPNA2 Protein, C-Flag-tagged Mammalian cells Flag
Human KPNA2-5816HF Recombinant Full Length Human KPNA2 Protein, GST-tagged In Vitro Cell Free System GST 529 amino acids
Human KPNA2-4897H Recombinant Human KPNA2 Protein, GST-tagged Wheat Germ GST
Human KPNA2-1261H Recombinant Human KPNA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human KPNA2-1261H-B Recombinant Human KPNA2 Protein Pre-coupled Magnetic Beads HEK293
Human KPNA2-4370H Recombinant Human KPNA2 Protein (Met1-Phe529), N-His tagged E.coli N-His Met1-Phe529
Human KPNA2-4372H Recombinant Human KPNA2 Protein (Ala157-Gln412), N-His tagged E.coli N-His Ala157-Gln412
Mouse KPNA2-8798M Recombinant Mouse KPNA2 Protein Mammalian Cell His
Mouse KPNA2-4896M-B Recombinant Mouse KPNA2 Protein Pre-coupled Magnetic Beads HEK293
Mouse KPNA2-4896M Recombinant Mouse KPNA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Kpna2-1279M Recombinant Mouse Kpna2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque KPNA2-2441R Recombinant Rhesus monkey KPNA2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque KPNA2-2262R Recombinant Rhesus Macaque KPNA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque KPNA2-2262R-B Recombinant Rhesus Macaque KPNA2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish KPNA2-484Z Recombinant Zebrafish KPNA2 Mammalian Cell His
Chicken KPNA2-1358C Recombinant Chicken KPNA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • KPNA2 Related Articles
  • KPNA2 Related Research Area

KPNA2 involved in several pathways and played different roles in them. We selected most pathways KPNA2 participated on our site, such as Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Influenza ABMA2;LOC100686744;IFNB1;IFNA3;TBK1;IFNA13;HLA-DQA1;EIF2AK3;DDX58

KPNA2 has several biochemical functions, for example, histone deacetylase binding, nuclear localization sequence binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNA2 itself. We selected most functions KPNA2 had, and list some proteins which have the same functions with KPNA2. You can find most of the proteins on our site.

Function Related Protein
histone deacetylase bindingMEF2D;WDTC1;PKN2;D7ERTD443E;CRY1;NCOR1;CEBPB;MECP2;BCOR
nuclear localization sequence bindingNUP214;KPNA1;KPNA5;RANBP6;KPNB1;KPNA6;KPNB3;IPO4;TNPO3
poly(A) RNA bindingTRIP6;C1orf53;SRSF5;LUC7L3;YWHAE;PARP1;RPL10;RALYL;SFPQ
protein bindingPRPS2;HBA2;C6orf130;NASP;NOMO2;SLX1B;CDON;FAM161A;ARHGEF12
protein transporter activitySEC62;COX18;KPNA3;L7RN6;KPNA1;AP1S3A;RUFY1;FRAG1;ZFYVE16

KPNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNA2.

L1; KPNB1; CHEK2; S100A6; S100A2

Zhang, CB; Kallakury, BV; et al. The significance of TNFAIP8 in prostate cancer response to radiation and docetaxel and disease recurrence. INTERNATIONAL JOURNAL OF CANCER 133:31-42(2013).
Dankof, A; Fritzsche, FR; et al. KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ. VIRCHOWS ARCHIV 451:877-881(2007).
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