kpna2
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  • Official Full Name
  • karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
  • Background
  • The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008]
  • Synonyms
  • KPNA2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); QIP2; RCH1; IPOA1; SRP1alpha; importin subunit alpha-1; pendulin; SRP1-alpha; RAG cohort 1; importin alpha 1; importin alpha 2; importin-alpha-P1; RAG cohort protein 1; importin subunit alpha-2; karyopherin subunit alpha-2;
Cat.#:KPNA2-4897HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KPNA2 Protein, GST-tagged
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Cat.#:KPNA2-1049HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KPNA2, His-tagged
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Cat.#:KPNA2-2900HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KPNA2, T7-tagged
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Cat.#:KPNA2-29809THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KPNA2, T7 -tagged
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Cat.#:KPNA2-8798MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KPNA2 Protein
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Cat.#:KPNA2-2441RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KPNA2 Protein, His-tagged
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Cat.#:KPNA2-1358CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KPNA2
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Cat.#:KPNA2-484ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KPNA2
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Cat.#:KPNA2-1389HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Karyopherin Alpha 2 (RAG cohort 1, importin alpha 1), His-tagged
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Cat.#:KPNA2-4891HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human KPNA2 293 Cell Lysate
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Involved Pathway

KPNA2 involved in several pathways and played different roles in them. We selected most pathways KPNA2 participated on our site, such as Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Influenza A
MAPK3; PRSS2; HSPA2; IFN-a; NXT2; HLA-DOA; IFNA5; TLR7; IL33; TNFSF10

Protein Function

KPNA2 has several biochemical functions, for example, histone deacetylase binding, nuclear localization sequence binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNA2 itself. We selected most functions KPNA2 had, and list some proteins which have the same functions with KPNA2. You can find most of the proteins on our site.
Function
Related Protein
Function histone deacetylase binding
Related Protein GMNN; GLI3; HES1; KAT2B; HDAC3; RBBP4; YWHAE; BRMS1L; GCM1; TOP2A
Function nuclear localization sequence binding
Related Protein NUP214; IPO4; KPNA6; KPNA5; KPNA7; TNPO1; KPNB3; TNPO3; IPO5; NFKBIA
Function poly(A) RNA binding
Related Protein SLTM; RTF1; DKC1; ELAC2; RAVER1; LSM2; PPIE; TRIP6; LUC7L3; DDX56
Function protein binding
Related Protein CRELD2; IKZF2; TMEM41A; Siglec1; ENPP1; CHMP6; TECPR2; EBF2; COG3; C2orf88
Function protein transporter activity
Related Protein ZFYVE16; SEC62; AP2B1; RANBP6; KPNA4; IPO4; RANGRF; AP2A2; AP2A1; TNPO1

Interacting Protein

KPNA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNA2.
L1; KPNB1; CHEK2; S100A6; S100A2

KPNA2 Related Articles

Zhang, CB; Kallakury, BV; et al. The significance of TNFAIP8 in prostate cancer response to radiation and docetaxel and disease recurrence. INTERNATIONAL JOURNAL OF CANCER 133:31-42(2013).
Dankof, A; Fritzsche, FR; et al. KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ. VIRCHOWS ARCHIV 451:877-881(2007).