• Official Full Name
  • LIM domain only 2 (rhombotin-like 1)
  • Background
  • LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms
  • LMO2; LIM domain only 2 (rhombotin-like 1); RBTNL1; rhombotin-2; RBTN2; RHOM2; rhombotin like 1; T cell translocation gene 2; TTG2; LMO-2; rhombotin 2; rhombotin-like 1; LIM domain only protein 2; T-cell translocation gene 2; cysteine-rich protein TTG-2; T-cell translocation protein 2
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey LMO2 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LMO2
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish LMO2
Source (Host):Species:Human
Product nameRecombinant Human LMO2 293 Cell Lysate

Involved Pathway

LMO2 involved in several pathways and played different roles in them. We selected most pathways LMO2 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with LMO2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Transcriptional misregulation in cancer

Protein Function

LMO2 has several biochemical functions, for example, E-box binding, RNA polymerase II activating transcription factor binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LMO2 itself. We selected most functions LMO2 had, and list some proteins which have the same functions with LMO2. You can find most of the proteins on our site.
Related Protein
Function E-box binding
Related Protein NEUROD2; ZEB1; BHLHE40; TAL1; NEUROG1; ASCL2; PER1; TFAP4; C1orf51; TCF4
Function RNA polymerase II activating transcription factor binding
Related Protein BEX1; HIPK2; ZFPM1; HEY2; CREB1; EP300; CTNNB1; NEUROD1; TBX20; POU1F1
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein BARHL1B; ETV5; ESX1; ZFAT; HES6; ATF5; ZNF79; RELA; TFAP2D; ATF2
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein FOXG1B; ZNF446; SP3; TP53; RUNX3; CC2D1B; NPAS4A; FOXA2; JUNBA; SOX9A
Function bHLH transcription factor binding
Related Protein USF1; SMAD3; TCF4; MAP3K10; SP1; TWIST1; RUNX2; BHLHE40; SIRT1; ISL1
Function chromatin binding
Related Protein NEUROG1; BCL6; PCNA; CIC; SKI; NFATC2; LDB1; C19orf40; SP110; PRIMPOL
Function cofactor binding
Related Protein C3; PGAM2; ME3; PHYH; UROS; PAH; LMO2; DAO; ACLYA; TYMS
Function protein binding
Related Protein LYN; FAF2; CD276; NBL1; CD14; HSPA4L; TOP3A; DOHH; C1S; EPB41B
Function transcriptional activator activity, RNA polymerase II transcription factor binding
Related Protein NOTCH1; WWP2; MIXL1; FOXH1; NR1H4; JUN; LMO2; NFE2L1; PITX1; CLOCK
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein TBX5; SRF; ELF5; EP300; SLAMF7; GATA6; GRHL2; MYOCD; MAFA; GATA2B
Function zinc ion binding
Related Protein ZNF276; NR1H5; KNG1; DTNA; ISL2B; ZBBX; FTR50; PHF19; RNFT2; BRF1A

Interacting Protein

LMO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LMO2.

LMO2 Related Articles

Zhang, J; Rabbitts, TH; et al. Intracellular antibody capture: A molecular biology approach to inhibitors of protein-protein interactions. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:1970-1976(2014).
Sewell, H; Tanaka, T; et al. Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. SCIENTIFIC REPORTS 4:-(2014).