LMO2
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Official Full Name
LIM domain only 2 (rhombotin-like 1) -
Overview
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms. -
Synonyms
LMO2;LIM domain only 2 (rhombotin-like 1);RBTNL1;rhombotin-2;RBTN2;RHOM2;rhombotin like 1;T cell translocation gene 2;TTG2;LMO-2;rhombotin 2;rhombotin-like 1;LIM domain only protein 2;T-cell translocation gene 2;cysteine-rich protein TTG-2;T-cell translocation protein 2
Recombinant Proteins
- Rhesus macaque
- Chicken
- Zebrafish
- Human
- Mouse
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LMO2-2534R | Recombinant Rhesus monkey LMO2 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| LMO2-5844C | Recombinant Chicken LMO2 | Mammalian Cells | Chicken | His |
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| LMO2-8735Z | Recombinant Zebrafish LMO2 | Mammalian Cells | Zebrafish | His |
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| LMO2-4710HCL | Recombinant Human LMO2 293 Cell Lysate | HEK293 | Human | Non |
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| Lmo2-1327M | Recombinant Mouse Lmo2 Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| LMO2-2354R | Recombinant Rhesus Macaque LMO2 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| LMO2-2354R-B | Recombinant Rhesus Macaque LMO2 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| LMO2-2399H | Recombinant Human LMO2 Protein, His-tagged | E.coli | Human | His | Met1-Gly156 |
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| LMO2-6221H | Recombinant Human LMO2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| LMO2-777H | Recombinant Human LMO2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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Involved Pathway
LMO2 involved in several pathways and played different roles in them. We selected most pathways LMO2 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with LMO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | HIST1H3F,PLAU,MYCN,HIST1H3D,ETV1,PBX3,ID2,ERG,BCL2A1A,SLC45A3 |
Protein Function
LMO2 has several biochemical functions, for example, E-box binding,RNA polymerase II activating transcription factor binding,RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LMO2 itself. We selected most functions LMO2 had, and list some proteins which have the same functions with LMO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II activating transcription factor binding | SIN3A,LDB1,MAD2L2,BEX1,TBX3,CREBBP,EP300,SETD3,CREB1,NCOR1 |
| transcriptional activator activity, RNA polymerase II transcription factor binding | FOXH1,MED12,KLF4,CREB1,NKX2,SOX10,CLOCK,JUN,KLF14,GBX2 |
| bHLH transcription factor binding | SMAD3,SP1,TCF4,TCF12,TCF3A,SIRT1,ISL1,IKZF4,TCF21,BHLHE40 |
| cofactor binding | C3,DAO,ACLY,HACL1,ASNS,ACLYA,HIF1AN,TYMS,ME3,UROS |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | MYF6,ETV5,CSRNP1,BHLHA15,HOXD8,SLAMF7,GATA5,GATA2B,GATA2,NR1I3 |
| protein binding | POLD4,SMC6,LDLRAP1,SPINK2,ZNF581,UBE2IB,FOXO1,TPCN2,SMPD1,SART3 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXD4L1,BMPR1A,ZNF576,LYL1,FOXD4,FOXO1,FOXR1,ELF3,SOX8B,PLAGX |
| zinc ion binding | S100A3,MBD1,ADAM15,PGGT1B,BBOX1,ISL1,TRAF1,MMP14,KDM5B,PPARD |
| RNA polymerase II regulatory region sequence-specific DNA binding | RELA,ZSCAN20,XBP1,FOXK1,PHF21A,FOXD3,ETV5,ETV7,HES6,CREB3L4 |
Interacting Protein
LMO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LMO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LMO2.
MAPRE3;HNRNPM;MAPRE2;LDB1;PHC2
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References
- Zhang, J; Rabbitts, TH; et al. Intracellular antibody capture: A molecular biology approach to inhibitors of protein-protein interactions. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:1970-1976(2014).
- Sewell, H; Tanaka, T; et al. Conformational flexibility of the oncogenic protein LMO2 primes the formation of the multi-protein transcription complex. SCIENTIFIC REPORTS 4:-(2014).
