mapk11
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  • Official Full Name
  • mitogen-activated protein kinase 11
  • Background
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
  • Synonyms
  • MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin
Cat.#:MAPK11-27606THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK11, His-tagged
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Cat.#:MAPK11-29HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAPK11, His-tagged
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Cat.#:MAPK11-373HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK11, GST-tagged, Active
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Cat.#:MAPK11-9527MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK11 Protein
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Cat.#:MAPK11-1375CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAPK11
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Cat.#:MAPK11-327ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK11
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Cat.#:MAPK11-734HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 11
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Cat.#:MAPK11-1045HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged
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Cat.#:MAPK11-1134HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged
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Cat.#:MAPK11-936HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, His-tagged
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Cat.#:MAPK11-4496HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK11 293 Cell Lysate
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Involved Pathway

MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF5; MAPK4; TGFB3; GRB2A; ELK1; NTRK1; TMEM37; RRAS2; GADD45BA; MAP3K5
Rap signaling pathway
PRKCB; GRIN1; SIPA1L1; FGF10; PFN1; FGF2; CALM4; FGF12; MAP2K3; PIK3CB
FoxO signaling pathway
PRKAA2; CCNB2; IGF1RB; HOMER3; SGK2A; INSB; NRAS; CDKN2D; PIK3R3; PIK3CG
Sphingolipid signaling pathway
PIK3R3; PDPK1; ROCK2; PRKCG; PPP2R5A; NSMAF; FCER1G; PPP2R2B; PPP2R3A; ASAH2
Adrenergic signaling in cardiomyocytes
MAPK12A; MAPK13; ADRA1D; TPM1; CALM2B; CAMK2D2; CACNA2D3; PPP2R1A; CACNG8; PPP2R1B
VEGF signaling pathway
PPP3CCA; PXNA; MAP2K2; PLCG1; PPP3R1B; PIK3CA; HSPB1; MAPK1; PIK3CG; PRKCA
Osteoclast differentiation
PPARG; PIK3CB; CALCR; cgr2b; NCF4; MAP3K14; SQSTM1; FOSB; PPP3R2; FOS
Signaling pathways regulating pluripotency of stem cells
FGFR2; WNT3; HNF1A; BMPR1B; SMAD3; WNT11; NANOG; AXIN1; WNT6; PIK3CD
Platelet activation
SNAP23; VAMP8; PLCB2; PLCB1; ORAI1; ACTG1; MYLK; PIK3R2; FCER1G; PRKACB
Toll-like receptor signaling pathway
IFNAR2; AKT3A; TLR4BB; MAPK1; IL12A; CCL3; TLR5B; RIPK1; CCL5; IFNPHI3
NOD-like receptor signaling pathway
CASPA; TNF; NAIP6; MAP3K7IP3; NLRP3; NFKBIB; CARD9; CXCL8B.3; IL6; MAPK3
RIG-I-like receptor signaling pathway
MAPK14B; PIN1; MAPK8; TRAF3; IFNPHI1; IL12B; IKBKE; NFKBIA; TBKBP1; Ifna11
T cell receptor signaling pathway
NFKBIE; PPP3CA; VAV3; Il2; PPP3CC; CBL; PIK3CD; CD8A; IKBKB; PIK3R2
Fc epsilon RI signaling pathway
MAP2K4; FCER1G; GAB2; PLA2G4C; MAPK12; MAP2K1; SOS1; FCER1A; MAPK11; IL13
TNF signaling pathway
MAP2K1; RPS6KA5; CASP7; VCAM1; CREB3L1; Ccl12; CXCL2; NFKB1; MMP9; MAP3K7
Leukocyte transendothelial migration
CDH5; PIK3R3; CXCL12; MYLPF; MYL10; TXK; NIPAL1; ACTN3; CLDN11; MYL5
Neurotrophin signaling pathway
BCL2; RAP1A; RPS6KA2; ATF4; KIDINS220; TP73; MAP2K2; CAMK4; NTF4; PIK3CA
Retrograde endocannabinoid signaling
GABRA6; GNG3; GNG4; GNG5; GNG13; GNB2; PRKACG; PRKCB; GNG7; GRIA4
Dopaminergic synapse
MAPK11; MAOB; PPP2R3C; CALY; PPP2CB; PPP3CC; PRKACA; GRIA4; GNAI2; GNG5
Inflammatory mediator regulation of TRP channels
CALM3; HTR2C; ACCN5; PPP1CC; BDKRB2; CYP4A14; PRKCQ; PRKCD; MAPK9; PIK3R2
GnRH signaling pathway
ELK1; CAMK2A; RAF1A; CACNA1DA; PTK2BB; CAMK2D1; PLCB2; CALM2A; CAMK2G1; CAMK2B1
Progesterone-mediated oocyte maturation
PRKACB; GNAI2A; MAPK8B; PKMYT1; CPEB1; CPEB3; MAPK14A; RPS6KA2; MAPK13; MAPK3
Prolactin signaling pathway
TNFRSF11A; SIRPA; MAPK10; MAPK9; MAPK8; MAPK12; MAP2K2; LHCGR; GSK3B; SOCS2
Amyotrophic lateral sclerosis (ALS)
TRP53; CASP1; PRPH; MAPK14; MAPK13; PPP3CB; CAT; TP53; PPP3CC; NEFL
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1G3; ATP6V0C; ATP6V1B2; ATP6V0A1; F11R; ATP6V0A2; CXCL1; ATP6V0E1; ATP6V1F; CCL5
Shigellosis
MAPK3; MAPK13; ABL1; ELMO3; ITGB1; ACTB; RHOG; RIPK2; WASL; CTTN
Salmonella infection
CDC42L2; WASLB; PFN2L; MAPK8; FLNA; RHOGC; KLC1A; KLC1B; IFNG; KLC1
Pertussis
GM5077; GNAI1; IRF1; Il23a; NOS2; CASP7; NLRP3; IRF3; IL6; CASP1
Leishmaniasis
IL4; MAPK12; HLA-DPA1; TAB2; FCGR3A; TLR2; MYD88; HLA-DRB5; MAPK13; IL12B
Chagas disease (American trypanosomiasis)
TLR9; AKT1; PLCB1; IL1B; C1QB; Ccl12; PIK3CD; C1QA; TNF; MAPK11
Toxoplasmosis
CYCS; LDLR; TLR4; LAMB4; HSPA2; STAT3; CASP8; H2-AB1; LY96; MYD88
Tuberculosis
CD209B; IRAK1; HLA-DRB1; CLEC4E; FCGR3A; Pla2r1; MYD88; CAP18; CEBPG; CD14
Hepatitis C
MAPK10; TRADD; IFNA13; KRAS; OAS3; TBK1; IFNAR2; EIF2AK1; MAVS; PPP2CA
Influenza A
IL12A; PRSS1; OAS1B; VDAC1; OAS1; IFNA10; HLA-DRA; IFNA3; HSPA2; Fasl
Epstein-Barr virus infection
EIF2AK3; IFNG; HLA-DPA1; TAB1; CSNK2B; SPN; NCOR2; PIK3R2; HLA-F; TBPL2
Proteoglycans in cancer
PXN; WNT9A; RPS6KB1; WNT11; RHOA; PAK1; ITGB1; AKT1; RDX; ITGA5

Protein Function

MAPK11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein P2RX7; TTLL11; DYRK4; NAGK; MARK2; HK2; ACTR2; ABCG2C; OXSR1A; DHX32
Function MAP kinase activity
Related Protein MAPK11; MAPK13; NLK2; MAPK4; MAPK6; MAPK7; MAPK12B; MAPK3; MAPK12; MAPK15
Function protein binding
Related Protein PSMA6; RPS3A; UBB; EEA1; DYSFIP1; LDLRAP1; MCM7; SPANXC; C10orf119; RIPK3
Function protein serine/threonine kinase activity
Related Protein PHKG1B; MAP4K4; DAPK1; MAP4K5; NIM1K; CDK15; LATS2; PAK1; AKT1; VPRBP

Interacting Protein

MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.
MAPK14; MAPKAPK3; ZNHIT1; TP53; ATF2; ATF2; TAB1; SOCS3; CPNE6; POLR3D; C9orf78; OBSL1; KRT1; SP1; MYB; VARS

MAPK11 Related Articles

Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).