mapk11
Share
  • Official Full Name
  • mitogen-activated protein kinase 11
  • Background
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
  • Synonyms
  • MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin
Cat.#:MAPK11-27606THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK11, His-tagged
+Inquiry
Cat.#:MAPK11-29HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAPK11, His-tagged
+Inquiry
Cat.#:MAPK11-373HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK11, GST-tagged, Active
+Inquiry
Cat.#:MAPK11-9527MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK11 Protein
+Inquiry
Cat.#:MAPK11-1375CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAPK11
+Inquiry
Cat.#:MAPK11-327ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK11
+Inquiry
Cat.#:MAPK11-734HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 11
+Inquiry
Cat.#:MAPK11-1045HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged
+Inquiry
Cat.#:MAPK11-1134HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged
+Inquiry
Cat.#:MAPK11-936HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, His-tagged
+Inquiry
Cat.#:MAPK11-4496HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK11 293 Cell Lysate
+Inquiry

Involved Pathway

MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPK8IP2; FLNB; CACNG6A; RPS6KA5; PPP3CC; MAPT; TGFB1; MAPK3; FGF13A; IKBKG
Rap signaling pathway
ID1; FGF18; RASGRP3; F2RL3; LPAR2; FGF13; CALM3; FGF22; RAPGEF1; MAP2K1
FoxO signaling pathway
GRB2; TGFB1; CDKN2D; PIK3R5; MAPK3; RAF1; PLK2; CCNB2; PRKAG1; GRM1
Sphingolipid signaling pathway
MAPK9; PRKCZ; PLCB4; TNF; BCL2; PIK3R1; RAF1; LASS2; MAPK3; RAC3
Adrenergic signaling in cardiomyocytes
CALM3; ATP1A1; PRKCA; CAMK2D1; ADCY9; ATP2B3B; MYL3; PPP2R2B; SLC9A1; SCN4BA
VEGF signaling pathway
PPP3CB; AKT2; SRC; NFATC2; PLA2G4A; MAPK14B; PRKCBA; KRAS; PPP3CC; HRASA
Osteoclast differentiation
SOCS1; SIRPG; RAC1; TREM2; CALCR; MAPK10; LILRB1; LILRA5; LILRA4; FCGR4
Signaling pathways regulating pluripotency of stem cells
FZD1; JARID2; DLX5; WNT10B; PIK3CD; INHBE; WNT2; WNT7A; NANOG; ID4
Platelet activation
FGA; SNAP23; MYLK4; PIK3R3; PRKACG; PIK3CG; PRKG1; STIM1; MAPK11; PLCB3
Toll-like receptor signaling pathway
TOLLIP; NFKB1; MAP2K1; TLR5; TAB2; MAP2K7; TLR4BA; MAPK1; MAP2K2B; IFNA4
NOD-like receptor signaling pathway
NFKB1; HSP90AA1.2; CCL2; TRAF6; HSP90AA1; Ccl12; TAB2; MAPK12; IL-8; MAPK14A
RIG-I-like receptor signaling pathway
IFNA5; CASP8; IFNA13; IL8L1; IKBKG; TANK; ATG5; IFNA17; IFNA16; IFNA12
T cell receptor signaling pathway
CABIN1; PIK3R5; CD28; PRKCQ; CD4; MAP3K14; CD40LG; PTPN6; SLA1; KRAS
Fc epsilon RI signaling pathway
MAP2K1; NRAS; RAC1; MAPK8; MAP2K7; MAPK9; MAP2K6; HRAS; MAP2K3; PIK3CG
TNF signaling pathway
RELA; MAP2K6; ICAM1; CREB3L2; MAGI2; CXCL3; CCL2; IL18R1; Casp3; CASP10
Leukocyte transendothelial migration
ESAM; CLDN22; TXK; VCAM1; MMP9; ACTN3; ITGB2L; CYBA; CLDN20; CLDN6
Neurotrophin signaling pathway
NTRK1; MAPK3; FASLG; CALM4; NRAS; RAP1A; PIK3R2; GAB1; MAP3K3; IRS1
Retrograde endocannabinoid signaling
GNB4; Adcy4; MAPK8; MAPK1; MAPK10; GNG13; GNG4; MAPK12; GABRE; MAPK9
Dopaminergic synapse
PPP2R3C; DRD5; GNG13; GNB2; PRKCA; CAMK2D; ITPR3; GNG8; DRD3; GRIA1
Inflammatory mediator regulation of TRP channels
HTR2C; ITPR1; ASIC3; PIK3CA; TRPV2; CALML5; CYP2C39; MAP2K6; PLCG2; PRKCA
GnRH signaling pathway
GNAS; CDC42L; CAMK2D2; ELK1; CALM2B; Adcy4; PLCB2; GNRH2; PRKCDA; HRASB
Progesterone-mediated oocyte maturation
ARAF; RPS6KA3; RAF1B; AKT2; CDC25C; AKT1; PRKACB; PRKACBB; MAP2K1; Adcy4
Prolactin signaling pathway
HRAS; SOCS4; ELF5; INS1; AKT1; IRF1; LHCGR; RAF1; NRAS; NEK3
Amyotrophic lateral sclerosis (ALS)
DERL1; BCL2; MAPK11; MAPK13; CASP9; GPX1; GRIN2D; CASP12; APAF1; BID
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1G1; IKBKB; SRC; MAP2K4; ATP6V1E2; ATP6V0A1; ATP6V0E1; ATP6AP1; MAP3K14; F11R
Shigellosis
ELMO2; WASF1; RELA; IL-8; SRC; PFN2; MAPK13; MAPK9; ACTG1; UBE2D2
Salmonella infection
ROCK2; KLC1A; IL8L1; FLNC; CCL3; WASLB; TJP1; PKN1; RELA; PFN4
Pertussis
CFL2; C1QA; GNAI2; C5; MAPK11; AMCF-II; C4BPA; Casp3; IL1B; LY96
Leishmaniasis
CYBA; MARCKSL1; FCGR3A; HLA-DRB1; HLA-DRB4; NCF4; FCGR1A; MYD88; MAPK3; ITGB2
Chagas disease (American trypanosomiasis)
MAPK8; MAPK3; TGFB3; IRAK4; MAPK11; IL-8; TGFBR2; PPP2R1A; IL1B; FOS
Toxoplasmosis
LAMA3; TGFB2; TAB2; HLA-DPB1; Casp3; BCL2L1; ITGB1; MAP3K7; MYD88; MAPK9
Tuberculosis
Ifna11; Itgam&Itgb2; CALM2; RIPK2; HLA-DOA; RAB7A; RHOA; TGFB3; AKT1; Ifna15
Hepatitis C
RXRA; IFNA5; EIF2AK2; AKT1; IFNA13; IFNA1; IKBKB; IKBKE; MAPK3; EIF2AK4
Influenza A
PIK3R3; PIK3R2; LOC780933; IFNAR1; AKT2; FAS; SOCS3; OAS1B; HLA-DQA1; HSPA1A
Epstein-Barr virus infection
PRKACA; POLR1C; HLA-DRB4; NEDD4; IFNG; HLA-A; PSMD6; CDK1; TRP53; TBPL1
Proteoglycans in cancer
CDC42; HIF1A; PRKCA; GPC1; PIK3R2; PPP1CA; NUDT16L1; PPP1R12B; MRAS; PRKACB

Protein Function

MAPK11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ABCA4; XRCC2; INSRR; DCLK2; MAP2K2; MELK; CLK3; TRIP13; RAD51B; UBE2O
Function MAP kinase activity
Related Protein MAPK13; MAPK14A; MAPK11; NLK1; NLK; MAPK3; MAPK6; MAPK7; MAPK14B; MAPK12B
Function protein binding
Related Protein P4HA3; CDK13; TTYH2; EHD1; ICA1L; KAT8; P2RX7; HIST1H2AK; FGFRL1B; CTSL2
Function protein serine/threonine kinase activity
Related Protein BRAF; MOS; MAPKAPK2; SYK; MARK4; PRKCI; LIMK2; PSKH1; MKNK1; MYO3A

Interacting Protein

MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.
MAPK14; MAPKAPK3; ZNHIT1; TP53; ATF2; ATF2; TAB1; SOCS3; CPNE6; POLR3D; C9orf78; OBSL1; KRT1; SP1; MYB; VARS

MAPK11 Related Articles

Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).