mapk11
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  • Official Full Name
  • mitogen-activated protein kinase 11
  • Background
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
  • Synonyms
  • MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin
Cat.#:MAPK11-27606THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK11, His-tagged
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Cat.#:MAPK11-29HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAPK11, His-tagged
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Cat.#:MAPK11-373HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK11, GST-tagged, Active
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Cat.#:MAPK11-9527MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK11 Protein
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Cat.#:MAPK11-1375CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAPK11
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Cat.#:MAPK11-327ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK11
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Cat.#:MAPK11-734HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 11
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Cat.#:MAPK11-1045HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged
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Cat.#:MAPK11-1134HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged
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Cat.#:MAPK11-936HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, His-tagged
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Cat.#:MAPK11-4496HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPK11 293 Cell Lysate
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Involved Pathway

MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP2K4B; PAK2B; NLK1; LAMTOR3; TAOK2; GADD45BB; MAP4K1; NFKB1; RAP1AA; MAPT
Rap signaling pathway
PRKCB; PIK3R5; VAV2; MRAS; FIGF; PARD6A; RAP1B; VEGFB; RAPGEF5; GRIN2A
FoxO signaling pathway
FOXG1A; MAPK10; TGFBR1; KLF2; PRKAG2; PTENB; KRAS; STAT3; GABARAPA; SGK2B
Sphingolipid signaling pathway
FCER1G; MAPK12; BID; S1PR4; SPHK2; RAF1; MAPK9; MAPK13; PIK3R2; SGMS1
Adrenergic signaling in cardiomyocytes
PPP2R2BB; FXYD2; CACNB2; RYR2; CREB3L3; PRKACA; CACNB4; ADRB3B; CREB3; MAPK12
VEGF signaling pathway
AKT1; VEGFAB; RAC2; PLCG1; NFATC2; RAC3A; AKT3A; PIK3R3; PLA2G4A; PTK2
Osteoclast differentiation
TNF; SIRPB1; IKBKB; CSF1; TNFSF11; PLCG2; MAPK12; TRAF6; TNFRSF11A; NFKB1
Signaling pathways regulating pluripotency of stem cells
ZFHX3; WNT16; PIK3CG; BMPR1A; BMP2; SMAD5; HNF1A; ZIC3; FGFR3; ID2
Platelet activation
GNAS; FGA; AKT2; PIK3R1; RHOA; PRKG1; GP5; PRKACA; MYL12A; PIK3CG
Toll-like receptor signaling pathway
TNF; IRF5; AKT2L; IFNAR1; MAPK3; PIK3R2; MYD88; MAP3K7; MAP2K2B; TLR9
NOD-like receptor signaling pathway
RELA; MAPK8A; NFKBIA; MAPK12A; HSP90AA1.1; RIPK2; HSP90AA1.2; NAIP6; NLRC4; PYDC1
RIG-I-like receptor signaling pathway
MAPK8A; MAPK11; MAPK8B; IFNB1; IL12BA; CASP10; MAPK10; TP-1; IL-8; RIPK1L
T cell receptor signaling pathway
CARD11; VAV3; DLG1; MAPK3; PIK3R2; PLCG1; MAP3K14; NFATC2; VAV2; CDC42
Fc epsilon RI signaling pathway
MAP2K3; LAT; MS4A2; AKT2; MAP2K2; RAC3; SYK; MAP2K1; VAV3; MAPK1
TNF signaling pathway
CREB5; TRAF3; LIF; PIK3CD; TNFAIP3; MAP2K4; BAG4; FAS; MAP2K6; MAPK13
Leukocyte transendothelial migration
MSN; PIK3CD; NOX3; PLCG1; ITGB2; ICAM1; CD99; ITGB1; GNAI3; CLDN22
Neurotrophin signaling pathway
TP53; SH2B1; BAX; MAPK7; PIK3R3; NFKB1; PIK3CD; PRKCD; RAC1; MAPK11
Retrograde endocannabinoid signaling
MAPK8; GNB3; GRIA1; PRKACA; ABHD6; NAPEPLD; SLC17A8; GABRP; PRKCA; GABRQ
Dopaminergic synapse
PPP1CC; GSK3A; PRKCA; FOS; SCN1A; CREB3L2; DRD3; GNAL; CAMK2D; DRD1
Inflammatory mediator regulation of TRP channels
ITPR1; NTRK1; CYP2J6; CAMK2G; GNAS; IL1RAP; HTR2A; P2RY2; CYP2J2; PRKCB
GnRH signaling pathway
PRKACA; MMP14B; CALM2B; GNRHR4; MMP2; MAPK7; GNA15.4; PRKCB; PLCB3; PLCB1
Progesterone-mediated oocyte maturation
CPEB3; CPEB2; MAPK14B; IGF1; PIK3CG; CDK1; RPS6KA3; IGF1R; MAD2L1; IGF1RA
Prolactin signaling pathway
CSN2; HRAS; PIK3R3; MAP2K1; SHC2; SOCS5; PRL; GSK3B; CSH; PIK3R1
Amyotrophic lateral sclerosis (ALS)
SLC1A2; GRIN2D; DERL1; PPP3R2; PPP3CA; TNFRSF1B; TOMM40; CCS; GRIN2A; DAXX
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1B2; JAM2; TJP1; ADAM17; ATP6V1F; MAPK10; ATP6V0C; LYN; ATP6V1B1; ATP6V1H
Shigellosis
RHOG; WASF1; CDC42; IKBKB; RAC1; PFN3; CTTN; RIPK2; RELA; ITGA5
Salmonella infection
DYNC1I1; MAPK13; LBP; FOS; CDC42L2; PKN2; MAPK8A; ARPC5A; KLC4; KLC1B
Pertussis
C3; CALM4; Itgam&Itgb2; MAPK8; FOS; AMCF-II; C2; IRF3; MAPK9; LY96
Leishmaniasis
HLA-DOA; HLA-DPA1; FOS; IFNGR2; FCGR3A; IL12A; ELK1; IFNG; NCF2; HLA-DQA1
Chagas disease (American trypanosomiasis)
MAPK11; Ccl12; MAP2K4; PLCB2; CFLAR; PPP2R2C; PLCB1; IL12B; PIK3R5; GNA11
Toxoplasmosis
TLR2; HLA-DRB4; IL10RA; BCL2L1; NFKBIB; AKT2; IL12B; TRAF6; H2-AA; PDPK1
Tuberculosis
IFNA7; Pla2r1; HLA-DOA; IFNG; PPP3R1; STAT1; TRAF6; RELA; MAPK3; IFNA17
Hepatitis C
MAVS; PPP2CA; PIK3CD; MAPK1; IFNA4; MAPK9; CLDN6; IFNA1; PPP2R2D; STAT3
Influenza A
MAPK1; Ccl12; ACTB; IRAK4; DNAJB1; IFNA16; IKBKB; PIK3R3; BMA1; CXCL10
Epstein-Barr virus infection
POLR3H; POLR3C; RB1; PSMD6; MAPK12; PSMD8; ICAM1; TBK1; POLR2H; PLCG1
Proteoglycans in cancer
WNT9B; MAP2K2; WNT5B; HOXD10; GRB2; ERBB2; CAV2; COL21A1; IGF2; WNT6

Protein Function

MAPK11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RTEL1; MAP2K7; DNAJA4; SLFNL1; DARS; ATP9B; RAD51D; TTLL11; MAP4K1; NME7
Function MAP kinase activity
Related Protein MAPK8A; MAPK13; MAPK11; MAPK14; MAPK1; MAPK6; MAPK14B; MAPK12B; MAPK15; MAPK4
Function protein binding
Related Protein HIF1AN; SPTA1; CDKN1A; PRDM16; NOV; AVPR1A; SDCCAG3; STATH; AIG1; RPL5
Function protein serine/threonine kinase activity
Related Protein FAM20C; PRKCZ; ACVR1L; PKN1B; ROCK2A; PRKCBB; TSSK3; CSNK1D; CAMK1DA; TTBK2

Interacting Protein

MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.
MAPK14; MAPKAPK3; ZNHIT1; TP53; ATF2; ATF2; TAB1; SOCS3; CPNE6; POLR3D; C9orf78; OBSL1; KRT1; SP1; MYB; VARS

MAPK11 Related Articles

Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).