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Official Full Name mitogen-activated protein kinase 11
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
Synonyms MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Mapk11-3939M Recombinant Mouse Mapk11 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human MAPK11-1045H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged E.coli GST
    Human MAPK11-1134H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged Sf9 Insect Cell GST
    Human MAPK11-27606TH Recombinant Human MAPK11, His-tagged E.coli His
    Human MAPK11-29H Recombinant human biotinylated MAPK11, His-tagged E.coli His
    Human MAPK11-373H Recombinant Human MAPK11, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK11-4496HCL Recombinant Human MAPK11 293 Cell Lysate HEK293 N/A
    Human MAPK11-734H Recombinant Human Mitogen-activated Protein Kinase 11 E.coli N/A
    Human MAPK11-936H Recombinant Human Mitogen-Activated Protein Kinase 11, His-tagged Human His
    Mouse MAPK11-9527M Recombinant Mouse MAPK11 Protein Mammalian Cell His
    Chicken MAPK11-1375C Recombinant Chicken MAPK11 Mammalian Cell His
    Zebrafish MAPK11-327Z Recombinant Zebrafish MAPK11 Mammalian Cell His

    MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway NFKB1; RPS6KA5; GADD45G; RPS6KA4; TMEM37; MAP3K13; HRASB; Fasl; ECSIT; MAP2K4
    Rap signaling pathway NGFR; MAPK13; FGF14; MAPK3; FARP2; PFN1; VAV2; FGF3; PGF; PFN3
    FoxO signaling pathway PDPK1B; SOS1; GADD45BB; STK4; KRAS; HOMER1B; MAPK8A; GRM1; FOXO1; TNFSF10
    Sphingolipid signaling pathway PRKCB; PLCB3; PPP2R5D; PIK3CB; FCER1A; MAPK1; PPP2R2C; PDPK1; BAX; LASS4
    Adrenergic signaling in cardiomyocytes ADRA1B; CALM2; CACNB3; AGTR2; CREB3L3L; VMHC; CACNB4A; TNNI3; GNAS; PPP1CA
    VEGF signaling pathway SH2D2A; PPP3CC; MAPK14A; VEGFAB; SRC; NRAS; MAP2K2; PRKCB; AKT2L; SPHK1
    Osteoclast differentiation SOCS3; LCP2; NCF4; STAT1; PIK3R2; AKT2; SIRPA; TNFRSF11A; MAP3K7; PPP3R2
    Signaling pathways regulating pluripotency of stem cells PIK3R1; NRAS; SMAD1; PIK3R3; HRAS; SMAD5; HOXB1; ACVR2B; ZFHX3; WNT16
    Platelet activation GUCY1B3; PPP1CB; PTGIR; SYK; P2RY12; PIK3R5; PIK3R2; GNAI1; GP1BA; GUCY1A3
    Toll-like receptor signaling pathway IFNB1; MAP2K2B; AKT3A; TLR5B; IFNA17; CCL3L1; IFNPHI1; IRF3; IFNA13; IL12B
    NOD-like receptor signaling pathway ERBB2IP; IL6; HSP90AA1; TRIP6; IL18; CCL5; NAIP6; RELA; MAPK3; LOC100033925
    RIG-I-like receptor signaling pathway MAPK8; FADD; MAPK13; IFNB1; TBK1; MAPK8B; DDX3X; IRF7; DDX3; MAP3K7
    T cell receptor signaling pathway GRB2; NFATC2; CD8A; SOS1; CD3E; CD3D; PAK6; PTPN6; PIK3R2; PTPRC; MAP3K14
    Fc epsilon RI signaling pathway VAV1; PIK3R1; MAPK13; RAF1; MAPK8; BTK; PIK3CB; INPP5D; SYK; MAP2K4
    TNF signaling pathway MAPK10; MAP2K7; CCL2; TRAF2; CXCL2; CXCL3; CASP10; NFKBIA; MMP14; TNF
    Leukocyte transendothelial migration PLCG2; PIK3R3; VCL; PIK3CG; MMP9; MMP2; VCAM1; ITGB2; ITGAL; NCF4
    Neurotrophin signaling pathway CALM2; BAD; TRP53; Fasl; NFKB1; TRAF6; CALM1; NFKBIB; AKT2; RAP1A
    Retrograde endocannabinoid signaling PRKACB; GNG11; GABRG3; GABRE; GRIA3; GNAI3; GRIA1; GABRA5; ITPR3; PLCB1
    Dopaminergic synapse GSK3B; MAOA; GNGT1; GNGT2; CREB5; PLCB2; DDC; GNB1; CALM2; GRIN2A
    Inflammatory mediator regulation of TRP channels PRKCE; MAP2K6; PRKCG; PIK3CB; P2RY2; ITPR1; PLA2G4D; IL1R1; PTGER4; ASIC1
    GnRH signaling pathway MAPK14B; MAP2K2A; MAP2K2; HBEGFA; MAPK11; RAF1; CALM2; ATF4; MMP14; PLD1
    Progesterone-mediated oocyte maturation CDC27; INSB; RPS6KAL; ARAF; CDC16; MAPK8A; MAPK14B; PPP1R2P9; CPEB1; ADCY1B
    Prolactin signaling pathway SOCS5; LHCGR; SLC2A2; MAPK9; STAT3; MAP2K1; MAPK8; SOS1; SOCS2; PIK3CB
    Amyotrophic lateral sclerosis (ALS) MAPK13; BCL2; PPP3CB; CASP12; MAPK14; CYCS; MAPK12; TP53; MAPK11; PPP3CC
    Epithelial cell signaling in Helicobacter pylori infection F11R; PLCG2; ADAM17; MET; ATP6V1G2; ATP6V0D1; ATP6V1G3; MAPK12; NOD1; SRC
    Shigellosis MAPK11; MAPK10; ROCK2; ELMO2; ACTG1; U2AF1L4; IL-8; PFN4; NFKBIB; U2AF1
    Salmonella infection KLC1A; PFN1; TLR4; NOS2A; ROCK1; MYD88; NOS2; RHOGD; CDC42L; PKN3
    Pertussis C4BP; CALM3; IRF3; MAPK1; C3; C1R; ITGAM; ITGB1; Il23a; C4BPA
    Leishmaniasis HLA-DPA1; FCGR2A; FCGR3A; IL1A; FCGR3B; PTPN6; IFNGR1; IL1B; H2-AB1; IRAK1
    Chagas disease (American trypanosomiasis) GNAS; PIK3CA; FOS; MAPK11; CCL5; PIK3R2; TLR4; FASLG; SMAD2; FAS
    Toxoplasmosis LAMB1; HLA-DQA2; Toxoplasma Gondii Major Surface Antigen P30; GNAI3; IL12A; CASP9; TLR4; H2-AA; PIK3R2; AKT1
    Tuberculosis CARD9; MYD88; HLA-DQA2; MAPK11; CD209B; PMAP-36; IFNA4; SPHK1; MAPK9; EP300
    Hepatitis C TP53; TNF; TRAF2; IFIT1; CLDN11; CLDN8; BRAF; PIK3R5; OSTN; IKBKB
    Influenza A MAP2K7; AKT1; MAP2K6; HLA-DQA1; PIK3R2; EIF2AK4; IL-8; IFNA10; HLA-DRA; TNF
    Epstein-Barr virus infection RELA; MAPK12; NFKBIB; POLR3C; PRKACB; PSMD11; POLR2J; HLA-DQA1; IL10RB; GTF2E2
    Proteoglycans in cancer PDCD4; PLAUR; GAB1; MAP2K1; FGFR1; IGF1; RPS6KB2; CTTN; PTCH1; MSN

    MAPK11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TRPM4; UBE2L3B; MAP2K4; ATP13A; CSF1R; DDX47; GSS; PFKP; IGF1RA; GTF2F2A
    MAP kinase activity MAPK15; NLK2; MAPK1; MAPK14B; MAPK13; MAPK12B; MAPK8A; MAPK12; MAPK4; NLK
    protein binding IFIT2; ASIC1; ELF1; CHAC1; KLC3; NRSN1; C4orf46; ICA1L; CRLF3; LNX1
    protein serine/threonine kinase activity MELK; MAST2; STK32A; STK17A; BCR; LIMK2; LRRK2; PRKCE; TAF1; CDK16

    MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.


    Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
    Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).

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