mapk11
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  • Official Full Name
  • mitogen-activated protein kinase 11
  • Background
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
  • Synonyms
  • MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin
Cat.#:MAPK11-27606THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK11, His-tagged
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Cat.#:MAPK11-29HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated MAPK11, His-tagged
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Cat.#:MAPK11-373HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAPK11, GST-tagged, Active
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Cat.#:MAPK11-9527MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK11 Protein
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Cat.#:MAPK11-1375CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAPK11
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Cat.#:MAPK11-327ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK11
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Cat.#:MAPK11-734HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 11
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Cat.#:MAPK11-1045HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged
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Cat.#:MAPK11-1134HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged
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Cat.#:MAPK11-936HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 11, His-tagged
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Cat.#:MAPK11-4496HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK11 293 Cell Lysate
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Involved Pathway

MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNA2D4; MAP2K7; MKNK2B; FGF20; CDC25B; PTPRR; MAPK9; FGF8; PAK2A; PLA2G4D
Rap signaling pathway
RAPGEF1; Itgam&Itgb2; PFN3; PDGFD; IGF1; MAP2K6; FGF21; THBS1; MAPK12; RAP1GAP
FoxO signaling pathway
G6PCA.1; TGFB1A; PTEN; KRAS; IRS1; CDKN2D; PIK3R5; CCNB2; GADD45G; PIK3CG
Sphingolipid signaling pathway
SPHK1; BCL2; PIK3CB; PPP2CB; PPP2R2A; PRKCB; BAX; NRAS; RAC1; NSMAF
Adrenergic signaling in cardiomyocytes
MYL2B; GNA15.4; ATP1A1; ADCY9; ATP1B3A; MYH7; ATP1A1A.1; CACNA2D2; ADRa1A; PPP2R5D
VEGF signaling pathway
PPP3R2; NRAS; MAPK3; PPP3CCA; CASP9; PIK3R2; SHC2; PTK2AB; MAPK13; MAPK1
Osteoclast differentiation
OSCAR; MAPK8; LILRA5; CYBA; TNFRSF1A; IFNAR1; cgr2b; FOSL1; LILRB4; SOCS3
Signaling pathways regulating pluripotency of stem cells
WNT8A; STAT3; FZD7; FGFR4; TCF3; FZD5; MAPK3; FGFR1; DLX5; ID4
Platelet activation
ARHGEF1; PLA2G4F; GNAI3; FERMT3; MAPK1; PTGIR; VASP; GNAI1; SNAP23; RAP1B
Toll-like receptor signaling pathway
RIPK1L; TLR1; TLR7; IKBKB; IFNA10; PIK3R5; AKT2L; TLR4BB; PIK3CG; PIK3CD
NOD-like receptor signaling pathway
LOC100033925; TNF; CCL2; SGUT1; CXCL8B.3; PYDC1; MAPK9; HSP90AB1; MAPK11; MAPK8A
RIG-I-like receptor signaling pathway
IL12BA; IFNB; MAPK12B; IFNA1; DDX58; MAPK8B; CASP8; IFIH1; IL12A; MAVS
T cell receptor signaling pathway
SOS1; MAP3K14; CD28; HRAS; NRAS; PRKCQ; PIK3R1; PTPRC; CD3E; PIK3CB
Fc epsilon RI signaling pathway
MAPK11; KRAS; BTK; NRAS; MAP2K1; MAPK9; PLCG1; FYN; MAPK13; PLCG2
TNF signaling pathway
MAP3K14; IKBKB; MMP14; PIK3R5; CXCL1; MAP2K1; MLKL; CXCL5; TRADD; TRAF2
Leukocyte transendothelial migration
CLDN3; JAM2; PIK3R2; AASS; PIK3R5; CLDN5; RAP1A; CLDN9; CLDN17; ROCK2
Neurotrophin signaling pathway
NFKBIB; PSEN2; CAMK2D; MAPK1; TP53; CALM1; CALM3; PDPK1; MAP2K1; BRAF
Retrograde endocannabinoid signaling
MAPK8; GABRE; SLC17A7; ITPR3; MAPK12; Adcy4; NAPEPLD; MAPK11; MAPK13; GABRA2
Dopaminergic synapse
MAPK12; GNG4; COMT; PPP1CA; GNB3; GRIA4; CREB5; PPP2R3C; GNG13; GNG8
Inflammatory mediator regulation of TRP channels
CAMK2A; PRKCA; GNAQ; CYP2J5; PIK3R2; Adcy4; CALM1; KLK1B4; PIK3CA; CYP2C39
GnRH signaling pathway
HRASB; GNRH2; GNRHR2; GNA11B; RAF1A; PLD2; LHBETA1; MMP14; CACNA1C; ELK1
Progesterone-mediated oocyte maturation
MAP2K1; MAPK10; CDC25A; CDC26; MAPK1; PRKACBA; PPP1R2P9; AKT2; GNAI1; CPEB2
Prolactin signaling pathway
CSN2; MAPK12; SOCS3; GSK3B; ESR2; MAPK8; PIK3CD; SOCS1; MAP2K2; PIK3CG
Amyotrophic lateral sclerosis (ALS)
MAPK11; CASP12; PRPH; GRIN2D; DAXX; MAP2K3; BAX; PPP3R2; GRIN1; TOMM40L
Epithelial cell signaling in Helicobacter pylori infection
IKBKG; CXCR1; ATP6V1E2; PAK1; IL-8; PLCG2; F11R; MAP3K14; MAPK10; ATP6V1G1
Shigellosis
IKBKG; RELA; ELMO1; PFN1; ATG5; DIAPH1; ACTG1; ROCK2; HCLS1; RAC1
Salmonella infection
ARPC5B; CDC42; RHOGC; ARPC5LB; PKN1; ACTB; PKN3; CCL3L3; NOS2B; CXCL1
Pertussis
C4BPB; IL12A; MAPK11; TLR4; C4A; AMCF-II; TRAF6; C4BP; LY96; IRF8
Leishmaniasis
HLA-DRA; HLA-DPB1; MAPK3; C3; HLA-DQA2; HLA-DMB; H2-AB1; NFKB1; HLA-DOB; ITGB1
Chagas disease (American trypanosomiasis)
PPP2CA; CASP8; CD247; LOC100033925; Il2; MAPK3; GNAI1; FADD; TGFBR1; MAP2K4
Toxoplasmosis
TRAF6; TLR2; IL12A; NOS2; PPIF; LAMB1; PIK3R3; MAPK1; TGFB2; MAPK9
Tuberculosis
MRC2; ATP6V0D2; LSP1; IL10RA; HLA-DQA2; AKT1; RFXAP; HLA-DMB; MYD88; IL23
Hepatitis C
PIK3R2; PIK3CA; IKBKE; CLDN15; CLDN10; STAT1; CLDN6; KRAS; TRAF3; IFIT1
Influenza A
IRAK4; TBK1; MAP2K3; Ifna11; IRF7; PIK3CB; TNFRSF10D; MAP2K6; AGFG1; SLC25A6
Epstein-Barr virus infection
IRF3; CD40; CD19; POLR2K; TYK2; HLA-DQB1; POLR2E; PSMD1; PTMA; PSMC5
Proteoglycans in cancer
IGF2; NANOG; GAB1; WNT5B; FN1; Fzd4; PXN; MSN; WNT8B; PRKCA

Protein Function

MAPK11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein IPPK; NME7; IGHMBP2; PDPK1A; NOL9; HK2; GUCY2F; DNAJA3A; AKT3A; FAM20C
Function MAP kinase activity
Related Protein MAPK6; MAPK4; MAPK12A; MAPK3; MAPK1; MAPK7; MAPK14A; MAPK12; MAPK8B; NLK
Function protein binding
Related Protein MXD1; GOLGA2; TPD52; DDL-2; KCNMB4; HES1; WLS; ATP6V1F; STAU1; L3MBTL4
Function protein serine/threonine kinase activity
Related Protein PRKCQ; LIMK1; CAMKK1B; SQSTM1; STK17B; PKMYT1; PHKG2; MAPK14; DCAMKL2; GSK3A

Interacting Protein

MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.
MAPK14; MAPKAPK3; ZNHIT1; TP53; ATF2; ATF2; TAB1; SOCS3; CPNE6; POLR3D; C9orf78; OBSL1; KRT1; SP1; MYB; VARS

MAPK11 Related Articles

Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).