mme
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  • Official Full Name
  • membrane metallo-endopeptidase
  • Background
  • This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5 untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MME; membrane metallo-endopeptidase; NEP; SFE; CD10; CALLA; neprilysin; enkephalinase; atriopeptidase; neprilysin-390; neprilysin-411; skin fibroblast elastase; neutral endopeptidase 24.11; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10);
Cat.#:MME-5409HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MME Protein, GST-tagged
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Cat.#:MME-567HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MME Protein, MYC/DDK-tagged
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Cat.#:MME-632HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Membrane Metallo-endopeptidase, His-tagged
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Cat.#:MME-008HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human MME Protein, His-tagged
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Cat.#:MME-1791HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MME protein, His-tagged
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Cat.#:MME-1807HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MME, His tagged
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Cat.#:MME-236HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human MME, StrepII-tagged
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Cat.#:MME-26365THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MME
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Cat.#:MME-264HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human MME, Fc tagged
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Cat.#:MME-265HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MME, None tagged
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Cat.#:Mme-168MTag:
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Mme
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Cat.#:Mme-169MTag:His
Source (Host):CHO cellsSpecies:Mouse
Product nameRecombinant Mouse Mme, His-tagged
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Cat.#:Mme-1792MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mme protein, His & GST-tagged
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Cat.#:Mme-266MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Mme, His tagged
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Cat.#:Mme-1793RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mme protein, His-tagged
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Cat.#:Mme-1794RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mme protein, His & GST-tagged
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Cat.#:Mme-29RTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Mme, His tagged
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Cat.#:MME-3707RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MME Protein
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Cat.#:MME-196CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MME, His-tagged
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Cat.#:MME-2789RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MME Protein, His-tagged
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Cat.#:MME-1230CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MME
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Cat.#:MME-1800HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human MME cell lysate
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Cat.#:MME-2688MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MME cell lysate
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Cat.#:MME-1083RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat MME cell lysate
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Cat.#:MME-001CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus MME cell lysate
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Cat.#:CDA081PTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD-10 Protein
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Involved Pathway

MME involved in several pathways and played different roles in them. We selected most pathways MME participated on our site, such as Renin-angiotensin system, Hematopoietic cell lineage, Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with MME were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Renin-angiotensin system
AGTR1B; KLK1B1; KLK1B9; KLK1B5; PRCP; ACE2; CPA3; KLK1B11; MME; CTSA
Hematopoietic cell lineage
CD1E; CD14; GM-CSF; CD59; Il6ra; THPO; GP1BB; CD19; HLA-DRB1; TNF
Protein digestion and absorption
COL6A6; SLC8A2; COL10A1; ATP1A1; KCNJ13; SLC36A1; COL7A1; PRCP; PRSS3; COL15A1
Alzheimers disease
CALM1; ATP5J; ATP5O; UQCR10; ATP5B; LRP1; PPP3CC; ITPR1; COX8A; COX7A1

Protein Function

MME has several biochemical functions, for example, endopeptidase activity, exopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MME itself. We selected most functions MME had, and list some proteins which have the same functions with MME. You can find most of the proteins on our site.
Function
Related Protein
Function endopeptidase activity
Related Protein ATG4B; SENP3B; TMEM59; TRAPPC12; MME; FAP; P4HB; KLK1B8; NCSTN; PSMB9
Function exopeptidase activity
Related Protein ACE; MME; GGH
Function metalloendopeptidase activity
Related Protein MMP17; ADAM8A; MMP2; OMA1; PAPLN; ADAM22; ADAMTS15A; MMP14; ADAM19; ADAMTS4
Function peptide binding
Related Protein NUP98; AVPR2L; AVPR2; HCRTR1; ANPEPB; PPYR1; CSNK1D; NPFFR1L1; CALR; CTSB
Function protein binding
Related Protein CDCA8; KCNMB4; CCNA1; EPO; SLC25A18; PELI1; EIF3A; ZNF559; ADNP; USF1
Function zinc ion binding
Related Protein PRKCBP1L; USP39; CHD4; RNF25; EHMT1B; ADAMDEC1; CAR3; ESR2B; RNF148; FHL2

Interacting Protein

MME has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MME here. Most of them are supplied by our site. Hope this information will be useful for your research of MME.
HSPB1; HSPA1A; CD9; ACTB; NDRG1; loc653596_human_protein; FAAH; SLC9A3R1; TM9SF1; IRAK2

MME Related Articles

Chakrabarti, S; Multani, S; et al. Whole genome expression profiling in chewing-tobacco-associated oral cancers: a pilot study. MEDICAL ONCOLOGY 32:-(2015).
Wekesa, SN; Sangula, AK; et al. Characterisation of recent foot-and-mouth disease viruses from African buffalo (Syncerus caffer) and cattle in Kenya is consistent with independent virus populations. BMC VETERINARY RESEARCH 11:-(2015).